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Gene · 29843

SENP1: SUMO specific peptidase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SENP1: SUMO specific peptidase 1. Genes, record 29843. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/29843

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Gene

Symbol
SENP1
HGNC
Name
SUMO specific peptidase 1
HGNC
NCBI Gene ID
29843
NCBI Gene
HGNC ID
HGNC:17927
HGNC
Ensembl
ENSG00000079387
NCBI Gene
Aliases
SuPr-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9P0U3Sentrin-specific protease 164410Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465770Q9P0U3Espacenet
JP 2026004568 A2026-01-1465773Q9P0U3Espacenet
JP 2026004568 A2026-01-1465775Q9P0U3Espacenet
EP 4650780 A22025-11-1912678Q9P0U3Espacenet
EP 4641201 A22025-10-2914033Q9P0U3Espacenet
JP 2025517969 A2025-06-1214033Q9P0U3Espacenet
JP 2025517970 A2025-06-1212678Q9P0U3Espacenet
US 11694765 B22023-07-04112Q9P0U3Espacenet
US 11694765 B22023-07-04114Q9P0U3Espacenet
US 11446398 B22022-09-2084926Q9P0U3Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants727

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSENP1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant62025
P30CA030199Cancer Center Support Grant (CCSG)52025
R01DK046492Engineered Glucose Metabolism in Insulin Secreting Cells52025
P30CA008748Cancer Center Support Grant42025
P30CA033572Cancer Center Support Grant42025
R01GM114362Computational methods for detecting patterns of complex genomic variation32025
T32AI007328Molecular Basis of Host Parasite Interaction32025
T32CA009110Training in Areas Fundamental to Cancer Research32025
P30CA010815Consolidated Basic Cancer Research Program22025
P30CA042014Cancer Center Support Grant22025

1 to 10 of 727Source NIH's project files

See all 727 nih grants

Papers1,435

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ZEB2 SUMOylation in Cardiac Fibroblast Drives Post-Infarction Cardiac Remodeling through CtBP1-Associated repression of Nr4a1.iScience202642602983PubTator, text miningPubMed
Blocking the aryl hydrocarbon receptor (AhR) protects CD4+ T cells from Th17/Treg differentiation imbalance through SENP1-mediated deSUMOylation.Hum Immunol202642468071PubTator, text miningPubMed
Corrigendum to "Bushentongluo formula counteracts BMSCs senescence to alleviate postmenopausal osteoporosis by activating mitophagy via the SENP1-SIRT3 pathway" [Phytomedicine 152 (2026) 157827].Phytomedicine202642392876PubTator, text miningPubMed
SENP1 drives glycolytic reprogramming to promote malignant progression of gastric cancer via deSUMOylation of HIF-1α.Tissue Cell202642378852PubTator, text miningPubMed
SUMOylation-stabilized G6PD orchestrates metabolic rewiring for oxidative stress survival and chemoresistance in HCC via a PKCδ-phosphorylation trigger.Cell Death Differ202642362742PubTator, text miningPubMed
Chromatin chronicles: Unlocking the therapeutic potential of histone modifiers in hepatocellular carcinoma.Med Oncol202642360649PubTator, text miningPubMed
Arsenic induced deubiquitination modification of PLCE1 in a de-SUMO-dependent manner to affect malignant behavior in bladder epithelial cells.J Hazard Mater202642335809PubTator, text miningPubMed
Senp1 O-GlcNAcylation Promotes Mitochondrial Fragmentation by Regulating Fis1 SUMO1-ylation Underlying Diabetic Cataract.Invest Ophthalmol Vis Sci202642334146PubTator, text miningPubMed
Lactate as a Chemical Modification on Proteins and Metabolites.Annu Rev Biochem202642331744PubTator, text miningPubMed
SENP1 mitigates intervertebral disc degeneration: mechanisms involving suppression of pyroptosis and apoptosis in nucleus pulposus cells.J Orthop Surg Res202642108475PubTator, text miningPubMed

1 to 10 of 1,435

See all 1,435 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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GET https://conductscience.org/api/genes/v1/29843/patents?page=2