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ICOS: inducible T cell costimulator

1 protein, 497 patents, 4 drugs, 14 trials, 4,775 NIH grants and 8,949 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolICOSHGNC
Nameinducible T cell costimulatorHGNC
NCBI Gene ID29851NCBI Gene
HGNC IDHGNC:5351HGNC
EnsemblENSG00000163600NCBI Gene
AliasesAILIM, CD278, CVID1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9Y6W8Inducible T-cell costimulator1992Ensembl, GeneID, HGNCUniProt

Patents 497

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4831196 A22026-10-2811Q9Y6W8Espacenet
EP 4806462 A22026-09-167Q9Y6W8Espacenet
US 12622954 B22026-05-121Q9Y6W8Espacenet
US 12624087 B22026-05-1211Q9Y6W8Espacenet
JP 2026074200 A2026-05-019Q9Y6W8Espacenet
JP 2026074200 A2026-05-0165Q9Y6W8Espacenet
US 12612446 B22026-04-28452Q9Y6W8Espacenet
JP 2026063215 A2026-04-1071Q9Y6W8Espacenet
US 12544440 B22026-02-1019Q9Y6W8Espacenet
EP 4680651 A12026-01-2164Q9Y6W8Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
FELADILIMABCHEMBL4297969Inducible T-cell costimulator agonistAGONISTChEMBL
MEDI-570CHEMBL2109449Inducible T-cell costimulator inhibitorINHIBITORChEMBL
ROZIBAFUSP ALFACHEMBL4650245Inducible T-cell costimulator inhibitorINHIBITORChEMBL
VOPRATELIMABCHEMBL4298004Inducible T-cell costimulator agonistAGONISTChEMBL

Trials 14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07217119FELADILIMABPHASE1/PHASE2ClinicalTrials.gov
NCT06790303FELADILIMABPHASE22025-06-04ClinicalTrials.gov
NCT05553808FELADILIMABPHASE22023-01-19ClinicalTrials.gov
NCT04549025VOPRATELIMABPHASE2ClinicalTrials.gov
NCT04428333FELADILIMABPHASE32022-05-25ClinicalTrials.gov
NCT04128696FELADILIMABPHASE32022-05-24ClinicalTrials.gov
NCT04126200FELADILIMABPHASE1/PHASE2ClinicalTrials.gov
NCT04058028ROZIBAFUSP ALFAPHASE22024-09-24ClinicalTrials.gov
NCT03989362VOPRATELIMABPHASE2ClinicalTrials.gov
NCT03739710FELADILIMABPHASE22025-06-15ClinicalTrials.gov

NIH grants 4775

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant982,025NIH's project files
P30CA016672Cancer Center Support Grant922,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award302,025NIH's project files
P51OD011132Emory National Primate Research Center272,025NIH's project files
U19AI082630Durable Alteration of the Human Immune system after Infection or Immunotherapy182,025NIH's project files
P30CA047904Cancer Center Support Grant172,025NIH's project files
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro172,025NIH's project files
R37AR040072Immune Responses in Lupus162,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies152,025NIH's project files
P30CA016042Cancer Center Support Grant152,025NIH's project files

Papers 8949

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42812204PubTator, text miningPubMed
42801723PubTator, text miningPubMed
42776797PubTator, text miningPubMed
42760831PubTator, text miningPubMed
42759981PubTator, text miningPubMed
42732976PubTator, text miningPubMed
42728606PubTator, text miningPubMed
42702822PubTator, text miningPubMed
42640721PubTator, text miningPubMed
42635795PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license