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Gene · 29881

NPC1L1: NPC1 like intracellular cholesterol transporter 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NPC1L1: NPC1 like intracellular cholesterol transporter 1. Genes, record 29881. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/29881

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Gene

Symbol
NPC1L1
HGNC
Name
NPC1 like intracellular cholesterol transporter 1
HGNC
NCBI Gene ID
29881
NCBI Gene
HGNC ID
HGNC:7898
HGNC
Ensembl
ENSG00000015520
NCBI Gene
Aliases
LDLCQ7, NPC11L1, SLC65A2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UHC9NPC1-like intracellular cholesterol transporter 11,3597Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455948Q9UHC9Espacenet
EP 4650780 A22025-11-193392Q9UHC9Espacenet
EP 4640849 A22025-10-29423Q9UHC9Espacenet
EP 4641201 A22025-10-292974Q9UHC9Espacenet
JP 2025529142 A2025-09-042873Q9UHC9Espacenet
US 12371689 B22025-07-292873Q9UHC9Espacenet
JP 2025519096 A2025-06-24423Q9UHC9Espacenet
JP 2025517969 A2025-06-122974Q9UHC9Espacenet
JP 2025517970 A2025-06-123392Q9UHC9Espacenet
US 11446398 B22022-09-2057706Q9UHC9Espacenet

1 to 10 of 16

See all 16 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
EZETIMIBECHEMBL1138Niemann-Pick C1-like protein 1 inhibitorINHIBITOR

Source ChEMBL

Trials192

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,022

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNPC1L1 papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)102025
P30DK056341Washington University Nutrition Obesity Research Center52025
R01AI078881Collaborative Integration of HCV Molecular Virology and Mathematical Modeling52025
ZIADK054503Molecular Approaches To Antiviral Development For Viral Hepatitis and Other Viral Diseases52025
ZIADK054505Therapy, Vaccine and Model Development in Viral Hepatitis and Liver Diseases52025
I01BX000152Regulation of Intestinal Bile Acid Absorption in Health and Cholesterol-Related Disorders42025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal42025
T32HL007208Integrated, Multidisciplinary Training in Cardiovascular Research42025
P30DK020579Diabetes Research Center32025
R01CA102184Functional Analysis of p53 Polymorphic Variants32025

1 to 10 of 1,022Source NIH's project files

See all 1,022 nih grants

Papers2,068

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Perinatal bisphenol AP exposure induces multigenerational cardiometabolic dysfunction via dysregulation of cholesterol synthesis and transport.Environ Pollut202642772435PubTator, text miningPubMed
Thermosonication-induced structural remodeling of faba bean protein: Improved functionality, digestibility, and cholesterol metabolism regulation for cardiovascular health.Ultrason Sonochem202642721809PubTator, text miningPubMed
Increased LDL-C reduction with ezetimibe in ketogenic diet-induced hypercholesterolemia.Lipids Health Dis202642661192PubTator, text miningPubMed
Global landscape of clinical trials and therapeutic targets in metabolic dysfunction-associated steatotic liver disease: an integrative multi-omics analysis.J Endocrinol Invest202642645756PubTator, text miningPubMed
Site-specific cholesterol depletion therapy for gastric cancer.J Lipid Res202642612977PubTator, text miningPubMed
[Research advance on regulation of SREBP pathway by TCM in prevention and treatment of hyperlipidemia].Zhongguo Zhong Yao Za Zhi202642543324PubTator, text miningPubMed
Lipids and Lipid-Lowering Drugs With Risk of Intervertebral Disc Degeneration: A Mendelian Randomization Study.Genet Res (Camb)202642528182PubTator, text miningPubMed
Site-specific cholesterol depletion therapy for gastric cancer.bioRxiv202642523283PubTator, text miningPubMed
Marigold flavonoids coordinate emulsion stabilization, epithelial transport and gut microbiota modulation to enhance intestinal lutein absorption.J Sci Food Agric202642517507PubTator, text miningPubMed
Corrigendum to "Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway" [Phytomedicine, 125 (2024), 155299].Phytomedicine202642509114PubTator, text miningPubMed

1 to 10 of 2,068

See all 2,068 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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