Gene · 29881
NPC1L1: NPC1 like intracellular cholesterol transporter 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NPC1L1: NPC1 like intracellular cholesterol transporter 1. Genes, record 29881. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/29881
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UHC9 | NPC1-like intracellular cholesterol transporter 1 | 1,359 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 55948 | Q9UHC9 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3392 | Q9UHC9 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 423 | Q9UHC9 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2974 | Q9UHC9 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2873 | Q9UHC9 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2873 | Q9UHC9 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 423 | Q9UHC9 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2974 | Q9UHC9 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3392 | Q9UHC9 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 57706 | Q9UHC9 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| EZETIMIBE | CHEMBL1138 | Niemann-Pick C1-like protein 1 inhibitor | INHIBITOR |
Source ChEMBL
Trials192
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07564726 | EZETIMIBE | PHASE3 | ClinicalTrials.gov | |
| NCT07524101 | EZETIMIBE | ClinicalTrials.gov | ||
| NCT07474649 | EZETIMIBE | PHASE3 | ClinicalTrials.gov | |
| NCT07442630 | EZETIMIBE | PHASE4 | ClinicalTrials.gov | |
| NCT07440381 | EZETIMIBE | PHASE3 | ClinicalTrials.gov | |
| NCT07432516 | EZETIMIBE | ClinicalTrials.gov | ||
| NCT07341958 | EZETIMIBE | ClinicalTrials.gov | ||
| NCT07313124 | EZETIMIBE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07307989 | EZETIMIBE | PHASE2 | ClinicalTrials.gov | |
| NCT07256171 | EZETIMIBE | ClinicalTrials.gov |
1 to 10 of 192
See all 192 trialsNIH grants1,022
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NPC1L1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK063491 | Diabetes Research Center (DRC) | 10 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 5 | 2025 |
| R01AI078881 | Collaborative Integration of HCV Molecular Virology and Mathematical Modeling | 5 | 2025 |
| ZIADK054503 | Molecular Approaches To Antiviral Development For Viral Hepatitis and Other Viral Diseases | 5 | 2025 |
| ZIADK054505 | Therapy, Vaccine and Model Development in Viral Hepatitis and Liver Diseases | 5 | 2025 |
| I01BX000152 | Regulation of Intestinal Bile Acid Absorption in Health and Cholesterol-Related Disorders | 4 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 4 | 2025 |
| T32HL007208 | Integrated, Multidisciplinary Training in Cardiovascular Research | 4 | 2025 |
| P30DK020579 | Diabetes Research Center | 3 | 2025 |
| R01CA102184 | Functional Analysis of p53 Polymorphic Variants | 3 | 2025 |
1 to 10 of 1,022Source NIH's project files
See all 1,022 nih grantsPapers2,068
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Perinatal bisphenol AP exposure induces multigenerational cardiometabolic dysfunction via dysregulation of cholesterol synthesis and transport. | Environ Pollut | 2026 | 42772435 | PubTator, text mining | PubMed |
| Thermosonication-induced structural remodeling of faba bean protein: Improved functionality, digestibility, and cholesterol metabolism regulation for cardiovascular health. | Ultrason Sonochem | 2026 | 42721809 | PubTator, text mining | PubMed |
| Increased LDL-C reduction with ezetimibe in ketogenic diet-induced hypercholesterolemia. | Lipids Health Dis | 2026 | 42661192 | PubTator, text mining | PubMed |
| Global landscape of clinical trials and therapeutic targets in metabolic dysfunction-associated steatotic liver disease: an integrative multi-omics analysis. | J Endocrinol Invest | 2026 | 42645756 | PubTator, text mining | PubMed |
| Site-specific cholesterol depletion therapy for gastric cancer. | J Lipid Res | 2026 | 42612977 | PubTator, text mining | PubMed |
| [Research advance on regulation of SREBP pathway by TCM in prevention and treatment of hyperlipidemia]. | Zhongguo Zhong Yao Za Zhi | 2026 | 42543324 | PubTator, text mining | PubMed |
| Lipids and Lipid-Lowering Drugs With Risk of Intervertebral Disc Degeneration: A Mendelian Randomization Study. | Genet Res (Camb) | 2026 | 42528182 | PubTator, text mining | PubMed |
| Site-specific cholesterol depletion therapy for gastric cancer. | bioRxiv | 2026 | 42523283 | PubTator, text mining | PubMed |
| Marigold flavonoids coordinate emulsion stabilization, epithelial transport and gut microbiota modulation to enhance intestinal lutein absorption. | J Sci Food Agric | 2026 | 42517507 | PubTator, text mining | PubMed |
| Corrigendum to "Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway" [Phytomedicine, 125 (2024), 155299]. | Phytomedicine | 2026 | 42509114 | PubTator, text mining | PubMed |
1 to 10 of 2,068
See all 2,068 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/29881
GET https://conductscience.org/api/genes/v1/29881/patents