Gene · 29927
SEC61A1: SEC61 translocon subunit alpha 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SEC61A1: SEC61 translocon subunit alpha 1. Genes, record 29927. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/29927
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P61619 | Protein transport protein Sec61 subunit alpha isoform 1 | 476 | 14 | Ensembl, GeneID, HGNC |
Source UniProt
Patents50
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 1086 | P61619 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3873 | P61619 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3873 | P61619 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1086 | P61619 | Espacenet |
| US 11898154 B2 | 2024-02-13 | 15 | P61619 | Espacenet |
| JP 2023554542 A | 2023-12-27 | 50 | P61619 | Espacenet |
| US 11694765 B2 | 2023-07-04 | 426 | P61619 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 76902 | P61619 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3804 | P61619 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 179873 | P61619 | Espacenet |
1 to 10 of 50
See all 50 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,700
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SEC61A1 papers | Newest fiscal year |
|---|---|---|---|
| R01GM052586 | Protein Transport Across Membranes | 14 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 8 | 2025 |
| R01CA172310 | Novel Targeted Anticancer Agents from Marine Cyanobacteria | 6 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| U19AI135990 | HPMI: Host Pathogen Mapping Initiative | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30DK045735 | Yale Diabetes Research Center | 4 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 4 | 2025 |
| R01DK099551 | New Congenital Disorders of Glycosylation: Therapy and Models | 4 | 2025 |
1 to 10 of 1,700Source NIH's project files
See all 1,700 nih grantsPapers2,113
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Cotranslational membrane protein biogenesis by an EMC-bound translocon. | Nat Struct Mol Biol | 2026 | 42806049 | PubTator, text mining | PubMed |
| From Guidelines to Practice: Pilot Implementation and Analytical Boundaries of a Focused ADPKD-Spectrum Gene Panel. | Diagnostics (Basel) | 2026 | 42739200 | PubTator, text mining | PubMed |
| Rare forms of autosomal dominant tubulointerstitial kidney disease in children: a retrospective case series from Oman. | Pediatr Nephrol | 2026 | 42730770 | PubTator, text mining | PubMed |
| COPI Coatomer Regulates Several Steps of HDL Metabolism. | Arterioscler Thromb Vasc Biol | 2026 | 42592650 | PubTator, text mining | PubMed |
| Hydrophobicity and signal sequence binding to the Sec complex: A single molecule biophysical perspective. | Biochem Biophys Res Commun | 2026 | 42566997 | PubTator, text mining | PubMed |
| α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson's disease. | Nat Commun | 2026 | 42562827 | PubTator, text mining | PubMed |
| Two helices are better than one: TMD-pairs redefine multipass membrane protein biogenesis. | Mol Cell | 2026 | 42561924 | PubTator, text mining | PubMed |
| Cytosolic transmembrane helices enter the ER membrane through EMC6-driven electrostatic interactions. | J Mol Cell Biol | 2026 | 42411831 | PubTator, text mining | PubMed |
| Advances in SEC61G research: from ER translocon subunit to emerging pan-cancer oncogenic roles. | Cancer Biol Ther | 2026 | 42345355 | PubTator, text mining | PubMed |
| Pairwise transmembrane domain insertion during multipass protein biogenesis. | Mol Cell | 2026 | 42341748 | PubTator, text mining | PubMed |
1 to 10 of 2,113
See all 2,113 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/29927
GET https://conductscience.org/api/genes/v1/29927/patents?page=2