ConductScience.org, home

Gene · 29927

SEC61A1: SEC61 translocon subunit alpha 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. SEC61A1: SEC61 translocon subunit alpha 1. Genes, record 29927. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/29927

On this page

Gene

Symbol
SEC61A1
HGNC
Name
SEC61 translocon subunit alpha 1
HGNC
NCBI Gene ID
29927
NCBI Gene
HGNC ID
HGNC:18276
HGNC
Ensembl
ENSG00000058262
NCBI Gene
Aliases
ADTKD5, CVID15, HNFJ4, HSEC61, SEC61, SEC61A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P61619Protein transport protein Sec61 subunit alpha isoform 147614Ensembl, GeneID, HGNC

Source UniProt

Patents50

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191086P61619Espacenet
JP 2025529142 A2025-09-043873P61619Espacenet
US 12371689 B22025-07-293873P61619Espacenet
JP 2025517970 A2025-06-121086P61619Espacenet
US 11898154 B22024-02-1315P61619Espacenet
JP 2023554542 A2023-12-2750P61619Espacenet
US 11694765 B22023-07-04426P61619Espacenet
US 11446398 B22022-09-2076902P61619Espacenet
US 11400116 B22022-08-023804P61619Espacenet
JP 2022524081 A2022-04-27179873P61619Espacenet

1 to 10 of 50

See all 50 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,700

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSEC61A1 papersNewest fiscal year
R01GM052586Protein Transport Across Membranes142025
P30DK034854Integrated Epithelial and Muscosal Biology82025
R01CA172310Novel Targeted Anticancer Agents from Marine Cyanobacteria62025
P30CA068485Cancer Center Support Grant52025
U19AI135990HPMI: Host Pathogen Mapping Initiative52025
P30CA016672Cancer Center Support Grant42025
P30CA030199Cancer Center Support Grant (CCSG)42025
P30DK045735Yale Diabetes Research Center42025
P30DK058404Molecular and Cellular Basis for Digestive Diseases42025
R01DK099551New Congenital Disorders of Glycosylation: Therapy and Models42025

1 to 10 of 1,700Source NIH's project files

See all 1,700 nih grants

Papers2,113

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cotranslational membrane protein biogenesis by an EMC-bound translocon.Nat Struct Mol Biol202642806049PubTator, text miningPubMed
From Guidelines to Practice: Pilot Implementation and Analytical Boundaries of a Focused ADPKD-Spectrum Gene Panel.Diagnostics (Basel)202642739200PubTator, text miningPubMed
Rare forms of autosomal dominant tubulointerstitial kidney disease in children: a retrospective case series from Oman.Pediatr Nephrol202642730770PubTator, text miningPubMed
COPI Coatomer Regulates Several Steps of HDL Metabolism.Arterioscler Thromb Vasc Biol202642592650PubTator, text miningPubMed
Hydrophobicity and signal sequence binding to the Sec complex: A single molecule biophysical perspective.Biochem Biophys Res Commun202642566997PubTator, text miningPubMed
α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson's disease.Nat Commun202642562827PubTator, text miningPubMed
Two helices are better than one: TMD-pairs redefine multipass membrane protein biogenesis.Mol Cell202642561924PubTator, text miningPubMed
Cytosolic transmembrane helices enter the ER membrane through EMC6-driven electrostatic interactions.J Mol Cell Biol202642411831PubTator, text miningPubMed
Advances in SEC61G research: from ER translocon subunit to emerging pan-cancer oncogenic roles.Cancer Biol Ther202642345355PubTator, text miningPubMed
Pairwise transmembrane domain insertion during multipass protein biogenesis.Mol Cell202642341748PubTator, text miningPubMed

1 to 10 of 2,113

See all 2,113 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/29927

GET https://conductscience.org/api/genes/v1/29927/patents?page=2