ConductScience.org, home

Gene · 29947

DNMT3L: DNA methyltransferase 3 like

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. DNMT3L: DNA methyltransferase 3 like. Genes, record 29947. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/29947

On this page

Gene

Symbol
DNMT3L
HGNC
Name
DNA methyltransferase 3 like
HGNC
NCBI Gene ID
29947
NCBI Gene
HGNC ID
HGNC:2980
HGNC
Ensembl
ENSG00000142182
NCBI Gene
Aliases
MGC1090
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UJW3Inactive DNA (cytosine-5)-methyltransferase DNMT3L38629Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4828973 A22026-10-2813Q9UJW3Espacenet
EP 4771137 A12026-07-08941Q9UJW3Espacenet
EP 4771157 A12026-07-08931Q9UJW3Espacenet
JP 2026510339 A2026-04-021497Q9UJW3Espacenet
EP 4713451 A22026-03-251124Q9UJW3Espacenet
EP 4713452 A22026-03-251497Q9UJW3Espacenet
EP 4677082 A22026-01-141497Q9UJW3Espacenet
JP 2026004568 A2026-01-1444071Q9UJW3Espacenet
EP 4641201 A22025-10-2923693Q9UJW3Espacenet
JP 2025147176 A2025-10-0614893Q9UJW3Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,207

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDNMT3L papersNewest fiscal year
P30CA008748Cancer Center Support Grant142025
R35GM119721Diversity Supplement: Mechanistic Insights into Mammalian DNA Methylation122025
P30CA016672Cancer Center Support Grant72025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)62025
R35GM134744Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms62025
R01CA183252DNMT3A in Development of Hematologic Malignancies52025
P30CA016042Cancer Center Support Grant42025
P30CA016056Roswell Park Cancer Center Support Grant42025
P30CA016086Cancer Center Support Grant42025
P30CA023168Cancer Center Support Grant42025

1 to 10 of 1,207Source NIH's project files

See all 1,207 nih grants

Papers1,845

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multidomain interaction governs the filamentous assembly of the dominant-negative DNMT3A R882H mutant.Proc Natl Acad Sci U S A202642640801PubTator, text miningPubMed
Clinical translation of epigenome editing technologies.Curr Opin Biomed Eng202642582990PubTator, text miningPubMed
Gonocytes in Transition: Establishing the Male Germline Identity.Adv Exp Med Biol202642455434PubTator, text miningPubMed
Mitochondrial translocation of DNMT3L suppresses oxidative phosphorylation and restrains megakaryopoiesis.Mitochondrion202642431335PubTator, text miningPubMed
Programmable aging function-related mitochondrial DNA 5-methylcytosine (m5C) modification with a TALE-directed methyltransferase.Cell Commun Signal202642365323PubTator, text miningPubMed
Dnmt3L Acetylation as a Post-Translational Switch Linking Extracellular Environment to Epigenetic Stability in Pluripotent Stem Cells.Stem Cell Rev Rep202642334736PubTator, text miningPubMed
DNMT3L affects synaptic function and induces neurobehavioral alterations in Drosophila via Sqd.Neurobiol Dis202642320545PubTator, text miningPubMed
Next generation technologies for CRISPR-based epigenome and transcriptional modulation.Curr Opin Biomed Eng202642266835PubTator, text miningPubMed
SUMO3/RUNX1/AIRE/RCAN1 and DNMT3L/DYRK1A/Let-7c-5p/VEGF axes: immune dysregulation and genetic susceptibility as pulmonary risk factors in Down syndrome.3 Biotech202642245386PubTator, text miningPubMed
A role of protein conformational dynamics in mammalian DNA methylation.Struct Dyn202642040493PubTator, text miningPubMed

1 to 10 of 1,845

See all 1,845 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/29947

GET https://conductscience.org/api/genes/v1/29947/patents?page=2