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Gene · 29978

UBQLN2: ubiquilin 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. UBQLN2: ubiquilin 2. Genes, record 29978. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/29978

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Gene

Symbol
UBQLN2
HGNC
Name
ubiquilin 2
HGNC
NCBI Gene ID
29978
NCBI Gene
HGNC ID
HGNC:12509
HGNC
Ensembl
ENSG00000188021
NCBI Gene
Aliases
ALS15, CHAP1, CHAP1/DSK2, Chap1, DSK2, Dsk2, HRIHFB2157, LIC-2, N4BP4, PLIC-2, PLIC2, RIHFB2157
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UHD9Ubiquilin-26244Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468853Q9UHD9Espacenet
EP 4650780 A22025-11-196954Q9UHD9Espacenet
EP 4638764 A22025-10-2910Q9UHD9Espacenet
EP 4641201 A22025-10-296814Q9UHD9Espacenet
JP 2025517969 A2025-06-126814Q9UHD9Espacenet
JP 2025517970 A2025-06-126954Q9UHD9Espacenet
JP 2025062601 A2025-04-1497Q9UHD9Espacenet
JP 2025038035 A2025-03-184447Q9UHD9Espacenet
US 12134655 B22024-11-054447Q9UHD9Espacenet
US 11884978 B22024-01-30791Q9UHD9Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants954

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUBQLN2 papersNewest fiscal year
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions112025
R01NS098243Mechanistic studies and therapeutics for ALS/FTD linked to UBQLN2 mutations82025
ZIAAG000933Genetic etiology of Amyotrophic Lateral Sclerosis72025
R01GM065334Solution structure and dynamics of polyubiquitin chains62025
R01NS097542RNA decay in amyotrophic lateral sclerosis and frontotemporal lobar degeneration52025
P30AG072931Michigan Alzheimer's Disease Research Center42025
R35NS122302Mechanisms of neurodegenerative diseases: intersections with ubiquitin pathways42025
T32AG000255Training in age related neurodegenerative diseases42025
ZIABC011490Maintaining cell health by targeted protein degradation42025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 954Source NIH's project files

See all 954 nih grants

Papers1,439

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ALS-associated exitron splicing produces UBQLN2 isoforms with distinct properties.bioRxiv202642818787PubTator, text miningPubMed
Reduced Soluble Ubiquilin2 in Amyotrophic Lateral Sclerosis Carrying Ubiquilin2 (P494L) Mutation: Clinicopathological and Biochemical Evidence From an Autopsy Case.Neuropathol Appl Neurobiol202642411953PubTator, text miningPubMed
The retroelement-derived human protein PEG10 is a regulator of mRNA splicing in neurons.bioRxiv202642239172PubTator, text miningPubMed
Conformational landscapes resolved by ion mobility mass spectrometry reveal mechanisms of polyubiquitin-controlled phase separation.Chem Sci202642205813PubTator, text miningPubMed
Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related decline.Commun Biol202642104039PubTator, text miningPubMed
STI1 domains coordinate partitioning of UBQLN2 into stress-induced condensates.bioRxiv202641959388PubTator, text miningPubMed
ALS mutations disrupt self-association between the ubiquilin STI1 hydrophobic groove and internal placeholder sequences.EMBO J202641862640PubTator, text miningPubMed
Amyotrophic Lateral Sclerosis (ALS) Genetics and Microbiota: A Comprehensive Review.Int J Mol Sci202641752118PubTator, text miningPubMed
TRIM32-UBQLN2-p62 axis promotes TDP-43 inclusion formation and amyloid aggregation through shuttle condensates.bioRxiv202641727138PubTator, text miningPubMed
Structures of the 26S proteasome in complex with the Hsp70 co-chaperone Bag1 reveal a mechanism for direct substrate transfer.Sci Adv202641719407PubTator, text miningPubMed

1 to 10 of 1,439

See all 1,439 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/29978

GET https://conductscience.org/api/genes/v1/29978/patents?page=2