Gene · 29978
UBQLN2: ubiquilin 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. UBQLN2: ubiquilin 2. Genes, record 29978. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/29978
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UHD9 | Ubiquilin-2 | 624 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 68853 | Q9UHD9 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6954 | Q9UHD9 | Espacenet |
| EP 4638764 A2 | 2025-10-29 | 10 | Q9UHD9 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6814 | Q9UHD9 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6814 | Q9UHD9 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6954 | Q9UHD9 | Espacenet |
| JP 2025062601 A | 2025-04-14 | 97 | Q9UHD9 | Espacenet |
| JP 2025038035 A | 2025-03-18 | 4447 | Q9UHD9 | Espacenet |
| US 12134655 B2 | 2024-11-05 | 4447 | Q9UHD9 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 791 | Q9UHD9 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants954
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | UBQLN2 papers | Newest fiscal year |
|---|---|---|---|
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 11 | 2025 |
| R01NS098243 | Mechanistic studies and therapeutics for ALS/FTD linked to UBQLN2 mutations | 8 | 2025 |
| ZIAAG000933 | Genetic etiology of Amyotrophic Lateral Sclerosis | 7 | 2025 |
| R01GM065334 | Solution structure and dynamics of polyubiquitin chains | 6 | 2025 |
| R01NS097542 | RNA decay in amyotrophic lateral sclerosis and frontotemporal lobar degeneration | 5 | 2025 |
| P30AG072931 | Michigan Alzheimer's Disease Research Center | 4 | 2025 |
| R35NS122302 | Mechanisms of neurodegenerative diseases: intersections with ubiquitin pathways | 4 | 2025 |
| T32AG000255 | Training in age related neurodegenerative diseases | 4 | 2025 |
| ZIABC011490 | Maintaining cell health by targeted protein degradation | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 954Source NIH's project files
See all 954 nih grantsPapers1,439
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| ALS-associated exitron splicing produces UBQLN2 isoforms with distinct properties. | bioRxiv | 2026 | 42818787 | PubTator, text mining | PubMed |
| Reduced Soluble Ubiquilin2 in Amyotrophic Lateral Sclerosis Carrying Ubiquilin2 (P494L) Mutation: Clinicopathological and Biochemical Evidence From an Autopsy Case. | Neuropathol Appl Neurobiol | 2026 | 42411953 | PubTator, text mining | PubMed |
| The retroelement-derived human protein PEG10 is a regulator of mRNA splicing in neurons. | bioRxiv | 2026 | 42239172 | PubTator, text mining | PubMed |
| Conformational landscapes resolved by ion mobility mass spectrometry reveal mechanisms of polyubiquitin-controlled phase separation. | Chem Sci | 2026 | 42205813 | PubTator, text mining | PubMed |
| Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related decline. | Commun Biol | 2026 | 42104039 | PubTator, text mining | PubMed |
| STI1 domains coordinate partitioning of UBQLN2 into stress-induced condensates. | bioRxiv | 2026 | 41959388 | PubTator, text mining | PubMed |
| ALS mutations disrupt self-association between the ubiquilin STI1 hydrophobic groove and internal placeholder sequences. | EMBO J | 2026 | 41862640 | PubTator, text mining | PubMed |
| Amyotrophic Lateral Sclerosis (ALS) Genetics and Microbiota: A Comprehensive Review. | Int J Mol Sci | 2026 | 41752118 | PubTator, text mining | PubMed |
| TRIM32-UBQLN2-p62 axis promotes TDP-43 inclusion formation and amyloid aggregation through shuttle condensates. | bioRxiv | 2026 | 41727138 | PubTator, text mining | PubMed |
| Structures of the 26S proteasome in complex with the Hsp70 co-chaperone Bag1 reveal a mechanism for direct substrate transfer. | Sci Adv | 2026 | 41719407 | PubTator, text mining | PubMed |
1 to 10 of 1,439
See all 1,439 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/29978
GET https://conductscience.org/api/genes/v1/29978/patents?page=2