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Gene · 2999

GZMH: granzyme H

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GZMH: granzyme H. Genes, record 2999. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2999

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Gene

Symbol
GZMH
HGNC
Name
granzyme H
HGNC
NCBI Gene ID
2999
NCBI Gene
HGNC ID
HGNC:4710
HGNC
Ensembl
ENSG00000100450
NCBI Gene
Aliases
CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20718Granzyme H2464Ensembl, GeneID, HGNC

Source UniProt

Patents69

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448210P20718Espacenet
EP 4650780 A22025-11-19338P20718Espacenet
EP 4641203 A22025-10-298P20718Espacenet
JP 2025147176 A2025-10-066355P20718Espacenet
JP 2025529142 A2025-09-046564P20718Espacenet
US 12371689 B22025-07-296564P20718Espacenet
JP 2025517967 A2025-06-128P20718Espacenet
JP 2025517970 A2025-06-12338P20718Espacenet
JP 2025028160 A2025-02-286355P20718Espacenet
KR 1020250017230 A2025-02-048P20718Espacenet

1 to 10 of 69

See all 69 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,203

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGZMH papersNewest fiscal year
P30CA008748Cancer Center Support Grant162025
UL1TR001863Yale Clinical and Translational Science Award132025
P30CA016672Cancer Center Support Grant92025
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro62025
U19AI082630Durable Alteration of the Human Immune system after Infection or Immunotherapy52025
P01AI039671Costimulatory Mechanisms of Autoimmunity42025
P30CA016087Cancer Center Support Grant42025
P30CA034196Cancer Center Support (CORE) Grant42025
P30CA076292Moffitt Cancer Center Support Grant42025
P30CA091842Cancer Center Support Grant42025

1 to 10 of 1,203Source NIH's project files

See all 1,203 nih grants

Papers1,418

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
In vivo effect of anti-PD-1 on HIV-specific CD8+T-cells in men with HIV.Nat Commun202642768041PubTator, text miningPubMed
Inflammaging reshapes the immune ecosystem in IgG4-related dacryoadenitis and sialadenitis.Rheumatology (Oxford)202642693941PubTator, text miningPubMed
Emerging roles of granzymes in neurodegeneration and neuroinflammation: mechanistic insights and therapeutic opportunities.Acta Neuropathol202642611377PubTator, text miningPubMed
Single-Cell Analysis Identifies Factors Associated with Rheumatoid Arthritis-Related Interstitial Lung Disease in Comparison with Idiopathic Pulmonary Fibrosis.Tuberc Respir Dis (Seoul)202642521633PubTator, text miningPubMed
CNS immune remodelling in SLE associated with anti-CD19 CAR-T therapy.Ann Rheum Dis202642493310PubTator, text miningPubMed
Integration of single-cell sequencing and transcriptomic analysis to identify novel diagnostic biomarkers for pre-eclampsia.BMC Pregnancy Childbirth202642477616PubTator, text miningPubMed
On the structure and function of granzymes, the deadly squad of cytotoxic lymphocytes.Biol Chem202642439535PubTator, text miningPubMed
Bone phenotype of patients with genetic forms of lipodystrophy: a systematic review of literature.J Clin Endocrinol Metab202642402919PubTator, text miningPubMed
Bone and Radiologic Findings in Congenital Generalized Lipodystrophy: A Systematic Review and Report of 60 Cases.J Bone Miner Res202642286916PubTator, text miningPubMed
Single-cell profiling reveals peripheral blood immune landscape remodelling in breast cancer lymph node metastasis.Clin Transl Med202642261224PubTator, text miningPubMed

1 to 10 of 1,418

See all 1,418 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2999

GET https://conductscience.org/api/genes/v1/2999/patents?page=2