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Gene · 3003

GZMK: granzyme K

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GZMK: granzyme K. Genes, record 3003. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3003

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Gene

Symbol
GZMK
HGNC
Name
granzyme K
HGNC
NCBI Gene ID
3003
NCBI Gene
HGNC ID
HGNC:4711
HGNC
Ensembl
ENSG00000113088
NCBI Gene
Aliases
GrK, PRSS, TRYP2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49863Granzyme K2642Ensembl, GeneID, HGNC

Source UniProt

Patents87

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19787P49863Espacenet
EP 4641203 A22025-10-2926P49863Espacenet
JP 2025147176 A2025-10-066356P49863Espacenet
JP 2025138725 A2025-09-251862P49863Espacenet
JP 2025529142 A2025-09-046565P49863Espacenet
US 12371689 B22025-07-296565P49863Espacenet
JP 2025517967 A2025-06-1226P49863Espacenet
JP 2025517970 A2025-06-12787P49863Espacenet
JP 2025028160 A2025-02-286356P49863Espacenet
KR 1020250017230 A2025-02-0426P49863Espacenet

1 to 10 of 87

See all 87 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,103

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGZMK papersNewest fiscal year
P30CA008748Cancer Center Support Grant212025
P30CA016672Cancer Center Support Grant212025
UL1TR001863Yale Clinical and Translational Science Award162025
P30AR070253Joint Biology Consortium Resource-based Center102025
R01AR063759Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state102025
T32HG002295Training in Bioinformatics and Integrative Genomics92025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital82025
P01AI039671Costimulatory Mechanisms of Autoimmunity72025
P01AI148102Differentiation of immune cells and fibrobalsts in inflamed tissue in RA and SLE62025
P30CA091842Cancer Center Support Grant62025

1 to 10 of 2,103Source NIH's project files

See all 2,103 nih grants

Papers2,892

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Metabolic dysfunction and GZMK+ CD8+ T-cell remodeling in hepatocellular carcinoma: an evidence-stratified, hypothesis-generating review.Front Immunol202642824776PubTator, text miningPubMed
Clonal CD8 T cells link peripheral and intrathecal immunity in ALS4 progression: a multiomics reference for ALS.Res Sq202642818511PubTator, text miningPubMed
Common viral infections seed regionally distinct resident memory T cells in the human CNS.bioRxiv202642818212PubTator, text miningPubMed
Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians.Int J Mol Sci202642794847PubTator, text miningPubMed
Pathogenic B-T Cell Axis Driven by BAFF Induces Endothelial Apoptosis in SLE-PAH.Circ Res202642779507PubTator, text miningPubMed
Beyond β-Adrenergic Receptor Brake: Compartment-Selective GRK2 Programs from Heart Failure to Cardio-Oncology.Kinases Phosphatases202642614945PubTator, text miningPubMed
Emerging roles of granzymes in neurodegeneration and neuroinflammation: mechanistic insights and therapeutic opportunities.Acta Neuropathol202642611377PubTator, text miningPubMed
Decoding benign prostatic hyperplasia at single-cell resolution: heterogeneity, inflammation, and beyond androgen-driven pathogenesis.Front Immunol202642568833PubTator, text miningPubMed
Circulating TFH2 Cell Expansion and GZMK+ TFH1 Cells are Associated with Allergic Rhinitis.J Asthma Allergy202642549226PubTator, text miningPubMed
Single-cell RNA-seq and spatial transcriptomics characterize CD8+ exhausted T cells in pancreatic ductal adenocarcinoma.iScience202642548877PubTator, text miningPubMed

1 to 10 of 2,892

See all 2,892 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3003

GET https://conductscience.org/api/genes/v1/3003/patents?page=2