Gene · 3003
GZMK: granzyme K
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GZMK: granzyme K. Genes, record 3003. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3003
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49863 | Granzyme K | 264 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents87
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 787 | P49863 | Espacenet |
| EP 4641203 A2 | 2025-10-29 | 26 | P49863 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6356 | P49863 | Espacenet |
| JP 2025138725 A | 2025-09-25 | 1862 | P49863 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6565 | P49863 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6565 | P49863 | Espacenet |
| JP 2025517967 A | 2025-06-12 | 26 | P49863 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 787 | P49863 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 6356 | P49863 | Espacenet |
| KR 1020250017230 A | 2025-02-04 | 26 | P49863 | Espacenet |
1 to 10 of 87
See all 87 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,103
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GZMK papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 21 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 21 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 16 | 2025 |
| P30AR070253 | Joint Biology Consortium Resource-based Center | 10 | 2025 |
| R01AR063759 | Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state | 10 | 2025 |
| T32HG002295 | Training in Bioinformatics and Integrative Genomics | 9 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 8 | 2025 |
| P01AI039671 | Costimulatory Mechanisms of Autoimmunity | 7 | 2025 |
| P01AI148102 | Differentiation of immune cells and fibrobalsts in inflamed tissue in RA and SLE | 6 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 2,103Source NIH's project files
See all 2,103 nih grantsPapers2,892
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Metabolic dysfunction and GZMK+ CD8+ T-cell remodeling in hepatocellular carcinoma: an evidence-stratified, hypothesis-generating review. | Front Immunol | 2026 | 42824776 | PubTator, text mining | PubMed |
| Clonal CD8 T cells link peripheral and intrathecal immunity in ALS4 progression: a multiomics reference for ALS. | Res Sq | 2026 | 42818511 | PubTator, text mining | PubMed |
| Common viral infections seed regionally distinct resident memory T cells in the human CNS. | bioRxiv | 2026 | 42818212 | PubTator, text mining | PubMed |
| Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians. | Int J Mol Sci | 2026 | 42794847 | PubTator, text mining | PubMed |
| Pathogenic B-T Cell Axis Driven by BAFF Induces Endothelial Apoptosis in SLE-PAH. | Circ Res | 2026 | 42779507 | PubTator, text mining | PubMed |
| Beyond β-Adrenergic Receptor Brake: Compartment-Selective GRK2 Programs from Heart Failure to Cardio-Oncology. | Kinases Phosphatases | 2026 | 42614945 | PubTator, text mining | PubMed |
| Emerging roles of granzymes in neurodegeneration and neuroinflammation: mechanistic insights and therapeutic opportunities. | Acta Neuropathol | 2026 | 42611377 | PubTator, text mining | PubMed |
| Decoding benign prostatic hyperplasia at single-cell resolution: heterogeneity, inflammation, and beyond androgen-driven pathogenesis. | Front Immunol | 2026 | 42568833 | PubTator, text mining | PubMed |
| Circulating TFH2 Cell Expansion and GZMK+ TFH1 Cells are Associated with Allergic Rhinitis. | J Asthma Allergy | 2026 | 42549226 | PubTator, text mining | PubMed |
| Single-cell RNA-seq and spatial transcriptomics characterize CD8+ exhausted T cells in pancreatic ductal adenocarcinoma. | iScience | 2026 | 42548877 | PubTator, text mining | PubMed |
1 to 10 of 2,892
See all 2,892 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3003
GET https://conductscience.org/api/genes/v1/3003/patents?page=2