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Gene · 3004

GZMM: granzyme M

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GZMM: granzyme M. Genes, record 3004. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3004

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Gene

Symbol
GZMM
HGNC
Name
granzyme M
HGNC
NCBI Gene ID
3004
NCBI Gene
HGNC ID
HGNC:4712
HGNC
Ensembl
ENSG00000197540
NCBI Gene
Aliases
LMET1, MET1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51124Granzyme M2574Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448212P51124Espacenet
EP 4650780 A22025-11-192366P51124Espacenet
JP 2025147176 A2025-10-066358P51124Espacenet
JP 2025529142 A2025-09-046566P51124Espacenet
US 12371689 B22025-07-296566P51124Espacenet
JP 2025517970 A2025-06-122366P51124Espacenet
JP 2025028160 A2025-02-286358P51124Espacenet
KR 1020250010750 A2025-01-216358P51124Espacenet
JP 2024109657 A2024-08-146365P51124Espacenet
JP 2023123507 A2023-09-05282P51124Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants957

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGZMM papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P01CA100730Retrovirus Models of Cancer62025
P30CA093373Cancer Center Support Grant P3062025
UL1TR001863Yale Clinical and Translational Science Award62025
P30CA016058Cancer Center Support Grant52025
P30CA013330Cancer Center Support Grant42025
P30CA046934University of Colorado Cancer Center Support Grant42025
ZIABC011255Genetic Modifiers of Initiation and Progression of Mammary Cancer42025
I01BX003824Advanced conformational changes in NOTCH3 and cerebrovascular disease severity32025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 957Source NIH's project files

See all 957 nih grants

Papers1,329

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Excess Met1-linked ubiquitination leads to solid aggregate formation.EMBO J202642806159PubTator, text miningPubMed
Integrative single-cell and bulk transcriptomic profiling identify peripheral T-cell-associated candidate biomarkers in community-acquired pneumonia.Int J Med Sci202642694836PubTator, text miningPubMed
OTULIN: a master regulator of linear ubiquitin homeostasis in immune signaling, inflammation, and disease.Front Immunol202642621935PubTator, text miningPubMed
On the structure and function of granzymes, the deadly squad of cytotoxic lymphocytes.Biol Chem202642439535PubTator, text miningPubMed
Linear ubiquitin chain assembly complex contributes to NLRP3-mediated pyroptotic cell death.iScience202642369039PubTator, text miningPubMed
Ubiquitination of glycogen and metabolites in cells and tissues.Nature202642020756PubTator, text miningPubMed
Immunomodulatory Roles and Clinical Significance of GZMM and DDX24 in Sepsis: A Multiomics Integrative Analysis With Experimental Validation.Hum Mutat202641948606PubTator, text miningPubMed
Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review).Int J Mol Med202641930562PubTator, text miningPubMed
DNA Methylation Dynamics in Plant Abiotic Stress Response: Mechanisms, Memory, and Breeding Applications.Genes (Basel)202641898835PubTator, text miningPubMed
Maternal opioid use disorder and hepatitis C infection in pregnancy reshape the peripheral immune landscape at term.EBioMedicine202641849830PubTator, text miningPubMed

1 to 10 of 1,329

See all 1,329 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3004

GET https://conductscience.org/api/genes/v1/3004/patents?page=2