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Gene · 3008

H1-4: H1.4 linker histone, cluster member

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. H1-4: H1.4 linker histone, cluster member. Genes, record 3008. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3008

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Gene

Symbol
H1-4
HGNC
Name
H1.4 linker histone, cluster member
HGNC
NCBI Gene ID
3008
NCBI Gene
HGNC ID
HGNC:4718
HGNC
Ensembl
ENSG00000168298
NCBI Gene
Aliases
H1.4, H1E, H1F4, H1e, H1s-4, HIST1H1E, RMNS, dJ221C16.5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P10412Histone H1.421926Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449166P10412Espacenet
EP 4650780 A22025-11-194515P10412Espacenet
EP 4641201 A22025-10-294070P10412Espacenet
EP 4641202 A22025-10-294821P10412Espacenet
JP 2025517969 A2025-06-124070P10412Espacenet
JP 2025517970 A2025-06-124515P10412Espacenet
KR 1020250017231 A2025-02-044821P10412Espacenet
US 12053567 B22024-08-068P10412Espacenet
JP 2024016122 A2024-02-06111P10412Espacenet
US 11446398 B22022-09-2038464P10412Espacenet

1 to 10 of 39

See all 39 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,230

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleH1-4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant192025
P30CA016058Cancer Center Support Grant132025
P30CA016672Cancer Center Support Grant52025
ZIABC010808Chromatin structure and dynamics52025
ZIASC000550Lymphoma Disease Discovery and Definition52025
R35GM122562Bridging Disparate Structural/Functional Scales: Multiscale Modeling of Genome Organization and of Viral RNA Frameshifting42025
ZIAMH002793PET Radiopharmaceutical Sciences42025
P01CA092584Structural Cell Biology of DNA Repair Machines32025
P30CA013330Cancer Center Support Grant32025
P30CA033572Cancer Center Support Grant32025

1 to 10 of 1,230Source NIH's project files

See all 1,230 nih grants

Papers2,254

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Time- and Dose-Resolved DIA-PASEF Proteomics Maps the Transition from Adaptive Stress to Apoptotic Collapse in Melittin-Treated MDA-MB-231 Cells.J Proteome Res202642695876PubTator, text miningPubMed
Linker Histone H1 Phosphorylation Promotes DNA Damage Repair during Replication Stress.ACS Chem Biol202642690615PubTator, text miningPubMed
Baseline Plasma Cell-Free and Circulating Tumor DNA Across Lymphoma Subtypes and Its Prognostic Impact in Diffuse Large B-Cell LymphomaAnn Lab Med202642613943PubTator, text miningPubMed
Expanding the clinical phenotype of HIST1H1E syndrome: cerebellar atrophy and bilateral optic neuropathy, a case report.Front Neurol202642318240PubTator, text miningPubMed
A Rahman Syndrome mutation in histone H1.4 disrupts chromatin compaction and phase separation.Nat Commun202642173878PubTator, text miningPubMed
Clinicopathological spectrum of CD10, BCL6, MUM1 triple-positive diffuse large B-cell lymphoma and large B-cell lymphoma with IRF4 rearrangement.Histopathology202642093218PubTator, text miningPubMed
Systemic immune profiling uncovers divergent mechanisms and predictive biomarkers of response to combination immunotherapies in hepatocellular carcinoma.J Immunother Cancer202641912268PubTator, text miningPubMed
Emergence of Catalytic Activity in VRK3: Phosphoproteomic Insights into the Regulatory Network of a Former Pseudokinase.Proteomes202641893729PubTator, text miningPubMed
Acute E-Cigarette Aerosol Condensate Exposure Disrupts the Transcriptome and Proteome Profiles of Human Bronchial Epithelial BEAS-2B Cells.Cells202641892316PubTator, text miningPubMed
Classifying Molecular Subtypes and Establishing a Prognosis Model using Oxidative Stress-related Genes for Lung Adenocarcinoma.Curr Med Chem202641863163PubTator, text miningPubMed

1 to 10 of 2,254

See all 2,254 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3008

GET https://conductscience.org/api/genes/v1/3008/patents?page=2