Gene · 3008
H1-4: H1.4 linker histone, cluster member
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. H1-4: H1.4 linker histone, cluster member. Genes, record 3008. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3008
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P10412 | Histone H1.4 | 219 | 26 | Ensembl, GeneID, HGNC |
Source UniProt
Patents39
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 49166 | P10412 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4515 | P10412 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4070 | P10412 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4821 | P10412 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4070 | P10412 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4515 | P10412 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4821 | P10412 | Espacenet |
| US 12053567 B2 | 2024-08-06 | 8 | P10412 | Espacenet |
| JP 2024016122 A | 2024-02-06 | 111 | P10412 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 38464 | P10412 | Espacenet |
1 to 10 of 39
See all 39 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,230
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | H1-4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 19 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 13 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| ZIABC010808 | Chromatin structure and dynamics | 5 | 2025 |
| ZIASC000550 | Lymphoma Disease Discovery and Definition | 5 | 2025 |
| R35GM122562 | Bridging Disparate Structural/Functional Scales: Multiscale Modeling of Genome Organization and of Viral RNA Frameshifting | 4 | 2025 |
| ZIAMH002793 | PET Radiopharmaceutical Sciences | 4 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 3 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 3 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,230Source NIH's project files
See all 1,230 nih grantsPapers2,254
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Time- and Dose-Resolved DIA-PASEF Proteomics Maps the Transition from Adaptive Stress to Apoptotic Collapse in Melittin-Treated MDA-MB-231 Cells. | J Proteome Res | 2026 | 42695876 | PubTator, text mining | PubMed |
| Linker Histone H1 Phosphorylation Promotes DNA Damage Repair during Replication Stress. | ACS Chem Biol | 2026 | 42690615 | PubTator, text mining | PubMed |
| Baseline Plasma Cell-Free and Circulating Tumor DNA Across Lymphoma Subtypes and Its Prognostic Impact in Diffuse Large B-Cell Lymphoma | Ann Lab Med | 2026 | 42613943 | PubTator, text mining | PubMed |
| Expanding the clinical phenotype of HIST1H1E syndrome: cerebellar atrophy and bilateral optic neuropathy, a case report. | Front Neurol | 2026 | 42318240 | PubTator, text mining | PubMed |
| A Rahman Syndrome mutation in histone H1.4 disrupts chromatin compaction and phase separation. | Nat Commun | 2026 | 42173878 | PubTator, text mining | PubMed |
| Clinicopathological spectrum of CD10, BCL6, MUM1 triple-positive diffuse large B-cell lymphoma and large B-cell lymphoma with IRF4 rearrangement. | Histopathology | 2026 | 42093218 | PubTator, text mining | PubMed |
| Systemic immune profiling uncovers divergent mechanisms and predictive biomarkers of response to combination immunotherapies in hepatocellular carcinoma. | J Immunother Cancer | 2026 | 41912268 | PubTator, text mining | PubMed |
| Emergence of Catalytic Activity in VRK3: Phosphoproteomic Insights into the Regulatory Network of a Former Pseudokinase. | Proteomes | 2026 | 41893729 | PubTator, text mining | PubMed |
| Acute E-Cigarette Aerosol Condensate Exposure Disrupts the Transcriptome and Proteome Profiles of Human Bronchial Epithelial BEAS-2B Cells. | Cells | 2026 | 41892316 | PubTator, text mining | PubMed |
| Classifying Molecular Subtypes and Establishing a Prognosis Model using Oxidative Stress-related Genes for Lung Adenocarcinoma. | Curr Med Chem | 2026 | 41863163 | PubTator, text mining | PubMed |
1 to 10 of 2,254
See all 2,254 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3008
GET https://conductscience.org/api/genes/v1/3008/patents?page=2