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Gene · 3015

H2AZ1: H2A.Z variant histone 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. H2AZ1: H2A.Z variant histone 1. Genes, record 3015. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3015

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Gene

Symbol
H2AZ1
HGNC
Name
H2A.Z variant histone 1
HGNC
NCBI Gene ID
3015
NCBI Gene
HGNC ID
HGNC:4741
HGNC
Ensembl
ENSG00000164032
NCBI Gene
Aliases
H2A.Z, H2A.Z-1, H2A.z, H2A/z, H2AFZ, H2AZ
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P0C0S5Histone H2A.Z12828Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193717P0C0S5Espacenet
WO 2025233441 A12025-11-13109P0C0S5Espacenet
WO 2025233441 A12025-11-13123P0C0S5Espacenet
EP 4641202 A22025-10-294738P0C0S5Espacenet
JP 2025517970 A2025-06-123717P0C0S5Espacenet
KR 1020250017231 A2025-02-044738P0C0S5Espacenet
US 11446398 B22022-09-2037070P0C0S5Espacenet
JP 2022524081 A2022-04-27140041P0C0S5Espacenet
US 11078247 B22021-08-034841P0C0S5Espacenet
US 11041865 B22021-06-221157P0C0S5Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,209

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleH2AZ1 papersNewest fiscal year
ZIAHL005801Genome-wide analysis of chromatin modifications202025
P30CA016672Cancer Center Support Grant142025
ZIAHL006030Epigenetic Regulation of T cell differentiation92025
ZIAHL006031Epigenetic Regulation of Embryonic and Hematopoietic Stem Cells82025
R01AI118891Viral modulation of epitranscriptomic mechanisms72025
P30CA010815Consolidated Basic Cancer Research Program62025
ZIABC005450Chromatin Structure and Gene Expression62025
P30CA008748Cancer Center Support Grant52025
P30CA016086Cancer Center Support Grant52025
P30CA046934University of Colorado Cancer Center Support Grant52025

1 to 10 of 2,209Source NIH's project files

See all 2,209 nih grants

Papers2,924

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Anp32e mediates histone variant H2A.Z-regulated TGF-β1 involvement in renal interstitial fibrosis.Biochim Biophys Acta Mol Basis Dis202742777513PubTator, text miningPubMed
Epigenetic training licenses naïve CD8+ T cell metabolic fitness and function.Sci Adv202642758848PubTator, text miningPubMed
Integrated analysis of bulk transcriptomics and single-cell transcriptomics revealed the association characteristics between heart failure and β-hydroxybutyrylation-related genes.PLoS One202642758764PubTator, text miningPubMed
Protamine gene expression is associated with sperm motility in rams: An integrative experimental and gene network analysis.Anim Reprod Sci202642748838PubTator, text miningPubMed
An H2A.Z-dependent epigenetic checkpoint in macrophages couples genetic risk to microbial metabolite signaling.Protein Cell202642745483PubTator, text miningPubMed
Integrative Molecular Profiling of miR-548f-3p in Triple-Negative Breast Cancer Highlights ANP32E as a Candidate Downstream Effector.Int J Mol Sci202642737491PubTator, text miningPubMed
Time- and Dose-Resolved DIA-PASEF Proteomics Maps the Transition from Adaptive Stress to Apoptotic Collapse in Melittin-Treated MDA-MB-231 Cells.J Proteome Res202642695876PubTator, text miningPubMed
Acetate suppresses tumorigenesis through ACSS2-dependent H2A.Z acetylation in esophageal squamous cell carcinoma.Cell Rep202642632021PubTator, text miningPubMed
Co-localization of TAZ and H2A.Z up-regulates IL-6 expression in alveolar epithelial cells to polarize M2 cells to alleviate hypoxia-induced lung injury.Genes Dis202642620447PubTator, text miningPubMed
ZNF512B associates with mitotic spindles, regulates metaphase exit, and is crucial for stem cell differentiation.Nucleic Acids Res202642578373PubTator, text miningPubMed

1 to 10 of 2,924

See all 2,924 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3015

GET https://conductscience.org/api/genes/v1/3015/patents?page=2