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Gene · 3021

H3-3B: H3.3 histone B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. H3-3B: H3.3 histone B. Genes, record 3021. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3021

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Gene

Symbol
H3-3B
HGNC
Name
H3.3 histone B
HGNC
NCBI Gene ID
3021
NCBI Gene
HGNC ID
HGNC:4765
HGNC
Ensembl
ENSG00000132475
NCBI Gene
Aliases
BRYLIB2, H3.3B, H3F3B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P84243Histone H3.3136103Ensembl, GeneID, HGNC

Source UniProt

Patents136

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026506083 A2026-02-20395P84243Espacenet
JP 2026004568 A2026-01-1448632P84243Espacenet
JP 2026004568 A2026-01-1448634P84243Espacenet
JP 2026004568 A2026-01-1448635P84243Espacenet
JP 2026004568 A2026-01-1448636P84243Espacenet
EP 4665855 A12025-12-24395P84243Espacenet
EP 4650780 A22025-11-191518P84243Espacenet
EP 4650780 A22025-11-1938940P84243Espacenet
EP 4650780 A22025-11-198114P84243Espacenet
EP 4641201 A22025-10-291132P84243Espacenet

1 to 10 of 136

See all 136 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,242

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleH3-3B papersNewest fiscal year
P30CA008748Cancer Center Support Grant252025
P30CA010815Consolidated Basic Cancer Research Program252025
P30CA016672Cancer Center Support Grant112025
R01AI118891Viral modulation of epitranscriptomic mechanisms102025
P30CA021765Cancer Center Support Grant (CCSG)92025
R01CA117830Epigenomic Control of KSHV Latency82025
P50CA097257Brain Tumor SPORE Grant62025
R01DE017336Epigenetic Regulation of Epstein-Barr Virus62025
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN52025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025

1 to 10 of 1,242Source NIH's project files

See all 1,242 nih grants

Papers1,611

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exploring Molecular Pathways in Metastasis of Breast Cancer Cells to the Brain: Insights from Gene Expression Analysis and Cellular Origins.J Microsc Ultrastruct202642824931PubTator, text miningPubMed
H3F3B gene mutation in chondroblastomas: a multicenter study.Acta Orthop Traumatol Turc202642813348PubTator, text miningPubMed
Exon-skipping antisense oligonucleotides for H3.3K27M-altered diffuse midline glioma therapy.Mol Ther Nucleic Acids202642656813PubTator, text miningPubMed
Stepwise Protocol for Alternative Splicing Analysis in Single-Cell SMART-Seq2 RNA-Seq Data.Bio Protoc202642367213PubTator, text miningPubMed
Clarification of the published survival analysis in H3F3B p.K27I-mutant diffuse midline glioma.Acta Neuropathol Commun202642321911PubTator, text miningPubMed
Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway.NAR Mol Med202642199921PubTator, text miningPubMed
Impact of Chromosomal Instability and Aneuploidy in Cancer Development.Annu Rev Cancer Biol202642137044PubTator, text miningPubMed
Uterine fluid extracellular vesicle miR-223-3p as endometrial receptivity biomarker and regulator in implantation.Reproduction202642118112PubTator, text miningPubMed
Evidence for coordinate CTCF and histone H3.3 activities in K27M diffuse midline gliomas.Acta Neuropathol Commun202642070015PubTator, text miningPubMed
In silico analysis of gene expression signatures and drug repurposing associated with metastatic progression in melanoma (skin cancer).Naunyn Schmiedebergs Arch Pharmacol202642068380PubTator, text miningPubMed

1 to 10 of 1,611

See all 1,611 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3021

GET https://conductscience.org/api/genes/v1/3021/patents?page=2