Gene · 3028
HSD17B10: hydroxysteroid 17-beta dehydrogenase 10
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HSD17B10: hydroxysteroid 17-beta dehydrogenase 10. Genes, record 3028. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3028
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | 261 | 15 | Ensembl, GeneID, HGNC |
Source UniProt
Patents37
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 49547 | Q99714 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 136 | Q99714 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 136 | Q99714 | Espacenet |
| US 11957687 B2 | 2024-04-16 | 10 | Q99714 | Espacenet |
| JP 2024507735 A | 2024-02-21 | 198 | Q99714 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39298 | Q99714 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 142269 | Q99714 | Espacenet |
| KR 1020210152990 A | 2021-12-16 | 21 | Q99714 | Espacenet |
| KR 1020210111195 A | 2021-09-10 | 21 | Q99714 | Espacenet |
| KR 1020200040204 A | 2020-04-17 | 21 | Q99714 | Espacenet |
1 to 10 of 37
See all 37 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,003
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HSD17B10 papers | Newest fiscal year |
|---|---|---|---|
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 8 | 2025 |
| R01GM117141 | Structural and functional basis for protein-based eukaryotic RNA processing | 6 | 2025 |
| P01AG026572 | Perimenopause in Brain Aging and Alzheimer's Disease | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30AI094189 | The Johns Hopkins Center for AIDS Research (JHU CFAR) | 3 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 3 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,003Source NIH's project files
See all 1,003 nih grantsPapers1,285
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Metabolomics-Driven Discovery of Targets for Hepatocytotoxicity Induced by Triphenyltin Chloride through Mitochondrial Function Involving HSD17B10 and HADH. | Environ Health (Wash) | 2026 | 42774750 | PubTator, text mining | PubMed |
| A Mitochondrial-Related Gene Signature for Diagnosis and Immune Microenvironment Modulation in Lung Cancer and Venous Thromboembolism. | World J Oncol | 2026 | 42730163 | PubTator, text mining | PubMed |
| Network pharmacology based identification of potential phytocompounds from Betula utilis in the treatment of leishmaniasis. | J Parasit Dis | 2026 | 42670328 | PubTator, text mining | PubMed |
| Integrated transcriptomic and tissue-validation analyses identify palmitoylation-associated biomarkers linked to sphingolipid metabolism and immune remodeling in psoriasis. | Front Immunol | 2026 | 42553137 | PubTator, text mining | PubMed |
| Development of Novel 17β-HSD10 Inhibitors and Their Evaluation in an In Vitro Model of Alzheimer's Disease. | ACS Med Chem Lett | 2026 | 42305190 | PubTator, text mining | PubMed |
| Oleuropein and hydroxytyrosol enhance mitochondrial function and biogenesis in SH-SY5Y cells through estrogen-like mechanisms. | Food Funct | 2026 | 42299956 | PubTator, text mining | PubMed |
| The inhibitors of 17β-HSD10: are they any good? | RSC Chem Biol | 2026 | 42282265 | PubTator, text mining | PubMed |
| High glucose impairs cognitive function by inducing lipid droplet accumulation through lactylation of HSD17B10 at K105. | Cell Rep | 2026 | 42275213 | PubTator, text mining | PubMed |
| Adult case of 17β-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency due to the p. Arg130Cys mutation of the HSD17B10 gene: case report. | AME Case Rep | 2026 | 41971928 | PubTator, text mining | PubMed |
| Alzheimer's disease: from molecular pathways to therapies. | Mol Biomed | 2026 | 41925951 | PubTator, text mining | PubMed |
1 to 10 of 1,285
See all 1,285 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3028
GET https://conductscience.org/api/genes/v1/3028/patents?page=2