Gene · 3030
HADHA: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HADHA: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha. Genes, record 3030. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3030
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P40939 | Trifunctional enzyme subunit alpha, mitochondrial | 763 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents38
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 185 | P40939 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 49510 | P40939 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10346 | P40939 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10346 | P40939 | Espacenet |
| EP 4463571 A1 | 2024-11-20 | 214 | P40939 | Espacenet |
| US 11813258 B2 | 2023-11-14 | 5 | P40939 | Espacenet |
| JP 2023521663 A | 2023-05-25 | 184 | P40939 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39182 | P40939 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 142153 | P40939 | Espacenet |
| JP 2022519460 A | 2022-03-24 | 29 | P40939 | Espacenet |
1 to 10 of 38
See all 38 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants984
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HADHA papers | Newest fiscal year |
|---|---|---|---|
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| ZIACP010121 | Molecular Epidemiology Studies of Occupational and Environmental Exposures | 4 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 3 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 3 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
| P30EY010572 | Ophthalmology Core Facility | 3 | 2025 |
| UL1TR001857 | University of Pittsburgh Clinical and Translational Science Institute | 3 | 2025 |
| ZIABC005562 | Xenobiotic receptors | 3 | 2025 |
1 to 10 of 984Source NIH's project files
See all 984 nih grantsPapers1,569
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Fatal Neonatal-Onset Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Caused by a Novel Homozygous HADHA Variant: A Case Report. | Z Geburtshilfe Neonatol | 2026 | 42790517 | PubTator, text mining | PubMed |
| Targeting a novel metabolic vulnerability of non-small cell lung cancer to fatty acid oxidation surmounts chemoresistance. | Drug Resist Updat | 2026 | 42556029 | PubTator, text mining | PubMed |
| Restoring Metabolic-Inflammatory Homeostasis: Curcumin's Multi-Layered Defense Against Chondrocyte Dysfunction. | Metabolites | 2026 | 42506457 | PubTator, text mining | PubMed |
| Author Correction: The mitochondrial β-oxidation enzyme HADHA restrains hepatic glucagon response by promoting β-hydroxybutyrate production. | Nat Commun | 2026 | 42425976 | PubTator, text mining | PubMed |
| Long-Chain Fatty Acid Oxidation Disorder Genes: A Comprehensive Genetic Database of LC-FAOD Variants, Genotypes, and Phenotypes. | Hum Mutat | 2026 | 42422157 | PubTator, text mining | PubMed |
| The prevalence of the common LCHAD c.1528G>C p.(Glu510Gln) pathogenic variant in women diagnosed with acute fatty liver of pregnancy. | Obstet Med | 2026 | 42333122 | PubTator, text mining | PubMed |
| Differential expression of metabolic genes distinguishes physiological from pathological cardiac hypertrophy. | BMC Cardiovasc Disord | 2026 | 42288718 | PubTator, text mining | PubMed |
| A tryptophan metabolism-related gene signature predicts prognosis and immune features in cutaneous melanoma. | Front Immunol | 2026 | 42238596 | PubTator, text mining | PubMed |
| Unraveling Key Genes Related to Fatty Acid Metabolism in Neuropathic Pain. | Drug Dev Res | 2026 | 42117748 | PubTator, text mining | PubMed |
| Integrated spatial multi-omics delineates fatty acid degradation fuels malignant evolution at the tumour periphery in cervical squamous cell carcinoma. | EBioMedicine | 2026 | 42048995 | PubTator, text mining | PubMed |
1 to 10 of 1,569
See all 1,569 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3030
GET https://conductscience.org/api/genes/v1/3030/patents?page=2