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Gene · 3030

HADHA: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HADHA: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha. Genes, record 3030. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3030

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Gene

Symbol
HADHA
HGNC
Name
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
HGNC
NCBI Gene ID
3030
NCBI Gene
HGNC ID
HGNC:4801
HGNC
Ensembl
ENSG00000084754
NCBI Gene
Aliases
ECHA, GBP, LCEH, LCHAD, MLCL AT, MTPA, TP-ALPHA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P40939Trifunctional enzyme subunit alpha, mitochondrial7633Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21185P40939Espacenet
JP 2026004568 A2026-01-1449510P40939Espacenet
EP 4650780 A22025-11-1910346P40939Espacenet
JP 2025517970 A2025-06-1210346P40939Espacenet
EP 4463571 A12024-11-20214P40939Espacenet
US 11813258 B22023-11-145P40939Espacenet
JP 2023521663 A2023-05-25184P40939Espacenet
US 11446398 B22022-09-2039182P40939Espacenet
JP 2022524081 A2022-04-27142153P40939Espacenet
JP 2022519460 A2022-03-2429P40939Espacenet

1 to 10 of 38

See all 38 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants984

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHADHA papersNewest fiscal year
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control62025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
P30CA016086Cancer Center Support Grant32025
P30CA062203Cancer Center Support Grant32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
P30EY010572Ophthalmology Core Facility32025
UL1TR001857University of Pittsburgh Clinical and Translational Science Institute32025
ZIABC005562Xenobiotic receptors32025

1 to 10 of 984Source NIH's project files

See all 984 nih grants

Papers1,569

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Fatal Neonatal-Onset Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Caused by a Novel Homozygous HADHA Variant: A Case Report.Z Geburtshilfe Neonatol202642790517PubTator, text miningPubMed
Targeting a novel metabolic vulnerability of non-small cell lung cancer to fatty acid oxidation surmounts chemoresistance.Drug Resist Updat202642556029PubTator, text miningPubMed
Restoring Metabolic-Inflammatory Homeostasis: Curcumin's Multi-Layered Defense Against Chondrocyte Dysfunction.Metabolites202642506457PubTator, text miningPubMed
Author Correction: The mitochondrial β-oxidation enzyme HADHA restrains hepatic glucagon response by promoting β-hydroxybutyrate production.Nat Commun202642425976PubTator, text miningPubMed
Long-Chain Fatty Acid Oxidation Disorder Genes: A Comprehensive Genetic Database of LC-FAOD Variants, Genotypes, and Phenotypes.Hum Mutat202642422157PubTator, text miningPubMed
The prevalence of the common LCHAD c.1528G>C p.(Glu510Gln) pathogenic variant in women diagnosed with acute fatty liver of pregnancy.Obstet Med202642333122PubTator, text miningPubMed
Differential expression of metabolic genes distinguishes physiological from pathological cardiac hypertrophy.BMC Cardiovasc Disord202642288718PubTator, text miningPubMed
A tryptophan metabolism-related gene signature predicts prognosis and immune features in cutaneous melanoma.Front Immunol202642238596PubTator, text miningPubMed
Unraveling Key Genes Related to Fatty Acid Metabolism in Neuropathic Pain.Drug Dev Res202642117748PubTator, text miningPubMed
Integrated spatial multi-omics delineates fatty acid degradation fuels malignant evolution at the tumour periphery in cervical squamous cell carcinoma.EBioMedicine202642048995PubTator, text miningPubMed

1 to 10 of 1,569

See all 1,569 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3030

GET https://conductscience.org/api/genes/v1/3030/patents?page=2