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HBA2: hemoglobin subunit alpha 2

1 protein, 209 patents, 2 drugs, 27 trials, 2,347 NIH grants and 7,592 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHBA2HGNC
Namehemoglobin subunit alpha 2HGNC
NCBI Gene ID3040NCBI Gene
HGNC IDHGNC:4824HGNC
EnsemblENSG00000188536NCBI Gene
AliasesECYT7, HBA-T2, HBHNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P69905Hemoglobin subunit alpha142356Ensembl, GeneID, HGNCUniProt

Patents 209

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4752548 A12026-06-035P69905Espacenet
JP 2026513230 A2026-04-2351P69905Espacenet
JP 2026004568 A2026-01-1448883P69905Espacenet
JP 2026004568 A2026-01-1448884P69905Espacenet
JP 2026501271 A2026-01-1424P69905Espacenet
KR 1020250166310 A2025-11-2751P69905Espacenet
WO 2025191111 A12025-09-1811P69905Espacenet
US 12297155 B22025-05-131P69905Espacenet
EP 4518890 A22025-03-12112P69905Espacenet
EP 4509607 A22025-02-193P69905Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EFAPROXIRALCHEMBL18901Hemoglobin HbA negative modulatorNEGATIVE MODULATORChEMBL
VOXELOTORCHEMBL4101807Hemoglobin HbA positive modulatorPOSITIVE MODULATORChEMBL

Trials 27

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06023199VOXELOTORPHASE2ClinicalTrials.gov
NCT05289570VOXELOTORPHASE22024-07-24ClinicalTrials.gov
NCT05228834VOXELOTORPHASE32024-05-02ClinicalTrials.gov
NCT05228821VOXELOTORPHASE4ClinicalTrials.gov
NCT05199766VOXELOTORPHASE2ClinicalTrials.gov
NCT05018728VOXELOTORPHASE2ClinicalTrials.gov
NCT04930445VOXELOTOR2025-12-31ClinicalTrials.gov
NCT04930328VOXELOTORClinicalTrials.gov
NCT04724421VOXELOTORClinicalTrials.gov
NCT04581356VOXELOTORPHASE4ClinicalTrials.gov

NIH grants 2347

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant122,025NIH's project files
R01DK103794Systematic Genetic Dissection of Human Erythropoiesis122,025NIH's project files
R01DK095112Regulatory Role of Transferrin in Erythropoiesis and Iron Metabolism102,025NIH's project files
U54DK106829Stem Cell and Transplantation Biology102,025NIH's project files
R01HL119479Regulation of Hemoglobin Switching92,025NIH's project files
U24HL135600Sickle Africa Data Coordinating Center92,025NIH's project files
P30CA016059Massey Cancer Center - Cancer Center Support Grant72,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)72,025NIH's project files
R01HG003143Structural Annotation of the Human Genome62,025NIH's project files
R01HL156647Base editing and prime editing for sickle cell disease62,025NIH's project files

Papers 7592

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42802820PubTator, text miningPubMed
42802446PubTator, text miningPubMed
42757138PubTator, text miningPubMed
42744602PubTator, text miningPubMed
42743614PubTator, text miningPubMed
42743118PubTator, text miningPubMed
42737742PubTator, text miningPubMed
42717792PubTator, text miningPubMed
42712823PubTator, text miningPubMed
42712766PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license