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HBB: hemoglobin subunit beta

1 protein, 181 patents, 4 drugs, 27 trials, 9,397 NIH grants and 22,237 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHBBHGNC
Namehemoglobin subunit betaHGNC
NCBI Gene ID3043NCBI Gene
HGNC IDHGNC:4827HGNC
EnsemblENSG00000244734NCBI Gene
AliasesCD113t-C, ECYT6, beta-globinNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P68871Hemoglobin subunit beta147350Ensembl, GeneID, HGNCUniProt

Patents 181

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026102694 A2026-06-23302P68871Espacenet
JP 2026097954 A2026-06-16100P68871Espacenet
JP 2026513230 A2026-04-2352P68871Espacenet
JP 2026048768 A2026-03-1723P68871Espacenet
JP 2026010071 A2026-01-212P68871Espacenet
JP 2026004568 A2026-01-1448886P68871Espacenet
KR 1020250166310 A2025-11-2752P68871Espacenet
EP 4650780 A22025-11-196063P68871Espacenet
EP 4640849 A22025-10-29873P68871Espacenet
EP 4641201 A22025-10-295796P68871Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BETIBEGLOGENE AUTOTEMCELCHEMBL4594311Hemoglobin beta chain exogenous geneEXOGENOUS GENEChEMBL
EFAPROXIRALCHEMBL18901Hemoglobin HbA negative modulatorNEGATIVE MODULATORChEMBL
LOVOTIBEGLOGENE AUTOTEMCELCHEMBL4650269Hemoglobin beta chain exogenous geneEXOGENOUS GENEChEMBL
VOXELOTORCHEMBL4101807Hemoglobin HbA positive modulatorPOSITIVE MODULATORChEMBL

Trials 27

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06023199VOXELOTORPHASE2ClinicalTrials.gov
NCT05289570VOXELOTORPHASE22024-07-24ClinicalTrials.gov
NCT05228834VOXELOTORPHASE32024-05-02ClinicalTrials.gov
NCT05228821VOXELOTORPHASE4ClinicalTrials.gov
NCT05199766VOXELOTORPHASE2ClinicalTrials.gov
NCT05018728VOXELOTORPHASE2ClinicalTrials.gov
NCT04930445VOXELOTOR2025-12-31ClinicalTrials.gov
NCT04930328VOXELOTORClinicalTrials.gov
NCT04724421VOXELOTORClinicalTrials.gov
NCT04581356VOXELOTORPHASE4ClinicalTrials.gov

NIH grants 9397

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant532,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant382,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)312,025NIH's project files
P30CA016672Cancer Center Support Grant302,025NIH's project files
P30CA013330Cancer Center Support Grant232,025NIH's project files
RM1HG009490Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease212,025NIH's project files
P01CA108671Myeloproliferative Neoplasms-Research Consortium202,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research182,025NIH's project files
P30CA016058Cancer Center Support Grant182,025NIH's project files
R01DK095112Regulatory Role of Transferrin in Erythropoiesis and Iron Metabolism182,025NIH's project files

Papers 22237

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42810305PubTator, text miningPubMed
42809541PubTator, text miningPubMed
42808383PubTator, text miningPubMed
42794552PubTator, text miningPubMed
42792951PubTator, text miningPubMed
42772556PubTator, text miningPubMed
42768929PubTator, text miningPubMed
42760781PubTator, text miningPubMed
42755959PubTator, text miningPubMed
42755327PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license