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Gene · 3055

HCK: HCK proto-oncogene, Src family tyrosine kinase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HCK: HCK proto-oncogene, Src family tyrosine kinase. Genes, record 3055. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3055

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Gene

Symbol
HCK
HGNC
Name
HCK proto-oncogene, Src family tyrosine kinase
HGNC
NCBI Gene ID
3055
NCBI Gene
HGNC ID
HGNC:4840
HGNC
Ensembl
ENSG00000101336
NCBI Gene
Aliases
AIPCV, JTK9, p59Hck, p61Hck
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08631Tyrosine-protein kinase HCK52640Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025247951 A12025-12-0461P08631Espacenet
US 11685954 B22023-06-27255P08631Espacenet
WO 2020043864 A12020-03-051088P08631Espacenet
US 10190166 B22019-01-2927P08631Espacenet
JP 2016104716 A2016-06-096P08631Espacenet
US 8986687 B22015-03-246P08631Espacenet
EP 2831104 A12015-02-041166P08631Espacenet
JP 2014526678 A2014-10-0627P08631Espacenet
JP 2013510831 A2013-03-286P08631Espacenet
WO 2013034569 A12013-03-1427P08631Espacenet

1 to 10 of 15

See all 15 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BOSUTINIBCHEMBL288441Tyrosine-protein kinase HCK inhibitorINHIBITORChEMBL
DASATINIB ANHYDROUSCHEMBL1421SRC inhibitorINHIBITORChEMBL
ENMD-981693CHEMBL52885SRC inhibitorINHIBITORChEMBL
ILORASERTIBCHEMBL1980297SRC inhibitorINHIBITORChEMBL
TG100-801CHEMBL403989SRC inhibitorINHIBITORChEMBL
XL-228CHEMBL3545085SRC inhibitorINHIBITORChEMBL

Trials266

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06423911BOSUTINIBPHASE3ClinicalTrials.gov
NCT06390319DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06355037DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06336395DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06297161BOSUTINIBClinicalTrials.gov
NCT06124157DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06055621DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT05993949DASATINIB ANHYDROUSPHASE1ClinicalTrials.gov
NCT05751044DASATINIB ANHYDROUSPHASE1/PHASE2ClinicalTrials.gov
NCT05559008DASATINIB ANHYDROUSPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 266

See all 266 trials

NIH grants1,893

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHCK papersNewest fiscal year
P30CA016672Cancer Center Support Grant202025
R01GM086858New Molecular Probes For Protein Kinases132025
P30CA008748Cancer Center Support Grant122025
P30CA036727Buffett Cancer Center Support Grant92025
P30CA068485Cancer Center Support Grant62025
P30CA076292Moffitt Cancer Center Support Grant62025
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR52025
P30CA034196Cancer Center Support (CORE) Grant52025
R35GM119437Dynamics of Ligand Binding and Protein Kinase Regulation52025
P30CA006927Comprehensive Cancer Center Program at Fox Chase42025

1 to 10 of 1,893Source NIH's project files

See all 1,893 nih grants

Papers2,931

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Elucidation of key lactylation- and palmitoylation-related genes and their related mechanisms in the development of neuropathic pain.Medicine (Baltimore)202642826297PubTator, text miningPubMed
Refining prostate cancer diagnosis: correlative analysis of Gleason scores and immunohistochemical markers.Diagn Pathol202642823706PubTator, text miningPubMed
Discovery of JH-XIII-05-01, a First-in-Class Dual IRAK1/IRAK4 Degrader for MYD88 Mutant Lymphomas.ACS Med Chem Lett202642741641PubTator, text miningPubMed
Identification of Critical Genes for Recurrent Aphthous Ulcer by Transcriptome Data Analysis and Mendelian Randomization.Oral Health Prev Dent202642714320PubTator, text miningPubMed
RAS P21 Protein Activator 3 finetunes Type I immunity by limiting HCK-mediated STAT4 phosphorylation.Nat Commun202642686775PubTator, text miningPubMed
In Silico and Molecular Docking Analysis of Benzyl Isothiocyanate from Salvadora persica as a Predicted Multi-Target Candidate for COVID-19 Host Responses.Curr Issues Mol Biol202642651847PubTator, text miningPubMed
Non-canonical function of transferrin receptor-1 promotes breast cancer metastasis by activating HCK‒STAT3‒MMP9 signalling.Clin Transl Med202642437977PubTator, text miningPubMed
Machine learning-based integration develops a novel lysosome-related prognostic signature associated with prognosis and immune infiltration landscape in acute myeloid leukemia.Discov Oncol202642334654PubTator, text miningPubMed
Constraining regulatory domain dynamics of the Src kinase Fgr increases ATP-site inhibitor sensitivity and impairs bone marrow engraftment.Cell Rep202642301812PubTator, text miningPubMed
Synthetic Substrate Discovery for Hck Kinase via Phage Display.Biochemistry202642283445PubTator, text miningPubMed

1 to 10 of 2,931

See all 2,931 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3055

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