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HCRT: hypocretin neuropeptide precursor

1 protein, 39 patents, 0 drugs, 0 trials, 2,860 NIH grants and 5,654 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHCRTHGNC
Namehypocretin neuropeptide precursorHGNC
NCBI Gene ID3060NCBI Gene
HGNC IDHGNC:4847HGNC
EnsemblENSG00000161610NCBI Gene
AliasesNRCLP1, OX, PPOXNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O43612Hypocretin neuropeptide precursor1315Ensembl, GeneID, HGNCUniProt

Patents 39

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026019942 A22026-01-22827O43612Espacenet
JP 2026004568 A2026-01-1449579O43612Espacenet
EP 4650780 A22025-11-193524O43612Espacenet
WO 2025227129 A22025-10-3036O43612Espacenet
JP 2025147176 A2025-10-066410O43612Espacenet
JP 2025529142 A2025-09-046578O43612Espacenet
US 12371689 B22025-07-296578O43612Espacenet
JP 2025517970 A2025-06-123524O43612Espacenet
JP 2025028160 A2025-02-286410O43612Espacenet
KR 1020250010750 A2025-01-216410O43612Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2860

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology162,025NIH's project files
P30DK072476Pennington/Louisiana NORC82,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)72,025NIH's project files
R01AG050518Hypocretin/orexin modulation of cognitive correlates of brain aging72,025NIH's project files
ZIAAA000550Neurobiology of Drug Reward and Addiction72,025NIH's project files
P30CA016672Cancer Center Support Grant62,025NIH's project files
P30CA056036Translational Research in Cancer52,025NIH's project files
R01AG060477Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSP52,025NIH's project files
R01DK107859Genetics of chronotype and impact on metabolic disease52,025NIH's project files
R01NS073613Molecular-Genetic Dissection of Subcortical Circuitry Regulating Arousal52,025NIH's project files

Papers 5654

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42814649PubTator, text miningPubMed
42813024PubTator, text miningPubMed
42774912PubTator, text miningPubMed
42767902PubTator, text miningPubMed
42750006PubTator, text miningPubMed
42748496PubTator, text miningPubMed
42715882PubTator, text miningPubMed
42714071PubTator, text miningPubMed
42710468PubTator, text miningPubMed
42710466PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license