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HTT: huntingtin

1 protein, 32 patents, 1 drug, 6 trials, 5,867 NIH grants and 12,546 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHTTHGNC
NamehuntingtinHGNC
NCBI Gene ID3064NCBI Gene
HGNC IDHGNC:4851HGNC
EnsemblENSG00000197386NCBI Gene
AliasesHD, IT15, LOMARSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P42858Huntingtin3,14231Ensembl, GeneID, HGNCUniProt

Patents 32

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4716542 A12026-04-0133P42858Espacenet
JP 2026004568 A2026-01-1449437P42858Espacenet
EP 4650780 A22025-11-197126P42858Espacenet
EP 4641201 A22025-10-297031P42858Espacenet
JP 2025529142 A2025-09-042018P42858Espacenet
US 12371689 B22025-07-292018P42858Espacenet
JP 2025517969 A2025-06-127031P42858Espacenet
JP 2025517970 A2025-06-127126P42858Espacenet
WO 2025080894 A12025-04-1742P42858Espacenet
WO 2024214071 A12024-10-1785P42858Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
TOMINERSENCHEMBL4297581Huntingtin mRNA antisense inhibitorANTISENSE INHIBITORChEMBL

Trials 6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05686551TOMINERSENPHASE2ClinicalTrials.gov
NCT04000594TOMINERSENPHASE12024-10-03ClinicalTrials.gov
NCT03842969TOMINERSENPHASE32023-08-31ClinicalTrials.gov
NCT03761849TOMINERSENPHASE32023-11-07ClinicalTrials.gov
NCT03342053TOMINERSENPHASE22021-01-19ClinicalTrials.gov
NCT02519036TOMINERSENPHASE1/PHASE22019-05-31ClinicalTrials.gov

NIH grants 5867

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P51OD011132Emory National Primate Research Center252,025NIH's project files
R01NS049206Huntington's Disease Repeat Instability and Pathogenesis252,025NIH's project files
R01ES010563Mechanisms of Manganese Neurotoxicity212,025NIH's project files
P30CA062203Cancer Center Support Grant192,025NIH's project files
P01CA092584Structural Cell Biology of DNA Repair Machines182,025NIH's project files
P40OD010440Caenorhabditis Genetics Center152,025NIH's project files
P51OD011092Support for National Primate Research Center152,025NIH's project files
R01NS073671Statistical Methods for Integrating Mixed-type Biomarkers and Phenotypes in Neurodegenerative Disease Modeling152,025NIH's project files
T32AG000266Training in Basic Research on Aging and Age-Related Disease152,025NIH's project files
ZIADK029023Structure and Dynamics Of Macromolecules In Solution By NMR142,025NIH's project files

Papers 12546

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819037PubTator, text miningPubMed
42817626PubTator, text miningPubMed
42814297PubTator, text miningPubMed
42811636PubTator, text miningPubMed
42801363PubTator, text miningPubMed
42786547PubTator, text miningPubMed
42786195PubTator, text miningPubMed
42782432PubTator, text miningPubMed
42779800PubTator, text miningPubMed
42768770PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license