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HDAC2: histone deacetylase 2

1 protein, 37 patents, 14 drugs, 659 trials, 6,050 NIH grants and 10,706 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHDAC2HGNC
Namehistone deacetylase 2HGNC
NCBI Gene ID3066NCBI Gene
HGNC IDHGNC:4853HGNC
EnsemblENSG00000196591NCBI Gene
AliasesHD2, KDAC2, RPD3, YAF1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q92769Histone deacetylase 248848Ensembl, GeneID, HGNCUniProt

Patents 37

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1915313Q92769Espacenet
EP 4641201 A22025-10-2918296Q92769Espacenet
JP 2025517969 A2025-06-1218296Q92769Espacenet
JP 2025517970 A2025-06-1215313Q92769Espacenet
EP 4464338 A22024-11-202286Q92769Espacenet
JP 2024123008 A2024-09-106461Q92769Espacenet
JP 2024525725 A2024-07-1214Q92769Espacenet
EP 4370698 A12024-05-2214Q92769Espacenet
US 11987605 B22024-05-2127Q92769Espacenet
US 11976334 B22024-05-07160Q92769Espacenet

Drugs 14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEXINOSTATCHEMBL2103863Histone deacetylase inhibitorINHIBITORChEMBL
BELINOSTATCHEMBL408513Histone deacetylase inhibitorINHIBITORChEMBL
CUDC-101CHEMBL598797Histone deacetylase inhibitorINHIBITORChEMBL
ENTINOSTATCHEMBL27759Histone deacetylase inhibitorINHIBITORChEMBL
FIMEPINOSTATCHEMBL3622533Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTATCHEMBL1213492Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTAT HYDROCHLORIDECHEMBL6068400Histone deacetylase inhibitorINHIBITORChEMBL
MOCETINOSTATCHEMBL272980Histone deacetylase 2 inhibitorINHIBITORChEMBL
PANOBINOSTATCHEMBL483254Histone deacetylase inhibitorINHIBITORChEMBL
PANOBINOSTAT LACTATECHEMBL3545368Histone deacetylase inhibitorINHIBITORChEMBL

Trials 659

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07492394ENTINOSTATPHASE2ClinicalTrials.gov
NCT07441486ENTINOSTATPHASE2ClinicalTrials.gov
NCT07330544ENTINOSTATPHASE2ClinicalTrials.gov
NCT07261592ENTINOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT07261241VORINOSTATPHASE2ClinicalTrials.gov
NCT07235618ENTINOSTATPHASE2ClinicalTrials.gov
NCT07217379VORINOSTATPHASE1ClinicalTrials.gov
NCT07150026VORINOSTATPHASE1ClinicalTrials.gov
NCT07150013VORINOSTATPHASE1ClinicalTrials.gov
NCT06995521VORINOSTATPHASE2ClinicalTrials.gov

NIH grants 6050

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant362,025NIH's project files
P30CA016672Cancer Center Support Grant362,025NIH's project files
P30ES001247Environmental Agents as Modulators of Disease Processes242,025NIH's project files
P30CA016058Cancer Center Support Grant192,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant172,025NIH's project files
R01GM049758Structure and Function of Metalloenzymes172,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant142,025NIH's project files
P30CA006973Regional Oncology Research Center102,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant102,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)102,025NIH's project files

Papers 10706

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42796563PubTator, text miningPubMed
42794528PubTator, text miningPubMed
42743758PubTator, text miningPubMed
42729152PubTator, text miningPubMed
42727056PubTator, text miningPubMed
42725196PubTator, text miningPubMed
42711949PubTator, text miningPubMed
42708874PubTator, text miningPubMed
42700714PubTator, text miningPubMed
42697041PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license