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Gene · 3068

HDGF: heparin binding growth factor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HDGF: heparin binding growth factor. Genes, record 3068. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3068

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Gene

Symbol
HDGF
HGNC
Name
heparin binding growth factor
HGNC
NCBI Gene ID
3068
NCBI Gene
HGNC ID
HGNC:4856
HGNC
Ensembl
ENSG00000143321
NCBI Gene
Aliases
HMG1L2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51858Hepatoma-derived growth factor2402Ensembl, GeneID, HGNC

Source UniProt

Patents55

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448965P51858Espacenet
JP 2026004568 A2026-01-1448970P51858Espacenet
EP 4650780 A22025-11-197420P51858Espacenet
EP 4641201 A22025-10-297375P51858Espacenet
JP 2025517969 A2025-06-127375P51858Espacenet
JP 2025517970 A2025-06-127420P51858Espacenet
US 12280021 B22025-04-2283P51858Espacenet
US 12269793 B22025-04-0883P51858Espacenet
EP 4257186 A22023-10-1183P51858Espacenet
US 11446398 B22022-09-2037838P51858Espacenet

1 to 10 of 55

See all 55 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants566

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHDGF papersNewest fiscal year
R37AI039394Biochemical Mechanism of HIV DNA Integration52025
R01AI052014HIV-1 Preintegration Trafficking and Nuclear Localization42025
P30CA008748Cancer Center Support Grant32025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study22025
P30AG066444Alzheimer's Disease Research Center22025
P30AI060354Harvard University Center for AIDS Research22025
P30CA010815Consolidated Basic Cancer Research Program22025
P30CA054174Mays Cancer Center at UT Health SA22025
P30DK063491Diabetes Research Center (DRC)22025
P30EY001792P30 Core Grant for Vision Research22025

1 to 10 of 566Source NIH's project files

See all 566 nih grants

Papers1,340

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetically supported targets and drug repurposing for sleep disorders: a Mendelian randomization systematic study.Naunyn Schmiedebergs Arch Pharmacol202642760376PubTator, text miningPubMed
Malic enzyme 1 senses L-lactate to determine tumor heterogeneity.Signal Transduct Target Ther202642728262PubTator, text miningPubMed
HDGF induces inflammatory cancer-associated fibroblast formation through ENO1-mediated glycolytic reprogramming in esophageal squamous-cell carcinoma.Cancer Lett202642595076PubTator, text miningPubMed
Lactylation-driven metabolic reprogramming promotes osteosarcoma malignancy via HDGF-mediated proliferation and immune modulation.Front Immunol202642245633PubTator, text miningPubMed
HDGF as a Novel Serological Marker for Proliferative Diabetic Retinopathy: A Mendelian Randomization and Cross-Sectional Study.Transl Vis Sci Technol202642171425PubTator, text miningPubMed
Multiscale Embedded Gene Co-Expression Network Combined with Mendelian Randomisation Analysis for the Molecular Pathogenesis of Breast Cancer.J Coll Physicians Surg Pak202642015432PubTator, text miningPubMed
Inhibition of circZFX suppresses malignant phenotypes in cholangiocarcinoma via the miR-654-3p/HDGF and YAP1 signaling activation.Biol Direct202642010436PubTator, text miningPubMed
Integrated spatial transcriptomics and pan-cancer XGBoost modeling uncover spatial drivers of immune exclusion and predict immunotherapy response.Cancer Immunol Immunother202641925746PubTator, text miningPubMed
Noninvasive, Rapid, and Precise Identification of Esophageal Cancer via Salivary Extracellular Vesicle-Based Diagnosis.ACS Nano202641910207PubTator, text miningPubMed
The role of miRNAs in the development of brain metastases originating from lung adenocarcinoma.Front Genet202641799343PubTator, text miningPubMed

1 to 10 of 1,340

See all 1,340 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3068

GET https://conductscience.org/api/genes/v1/3068/patents?page=2