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Gene · 3073

HEXA: hexosaminidase subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HEXA: hexosaminidase subunit alpha. Genes, record 3073. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3073

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Gene

Symbol
HEXA
HGNC
Name
hexosaminidase subunit alpha
HGNC
NCBI Gene ID
3073
NCBI Gene
HGNC ID
HGNC:4878
HGNC
Ensembl
ENSG00000213614
NCBI Gene
Aliases
TSD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P06865Beta-hexosaminidase subunit alpha5292Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026094091 A2026-06-0920P06865Espacenet
JP 2026067851 A2026-04-21279P06865Espacenet
JP 2026004568 A2026-01-1449027P06865Espacenet
EP 4650780 A22025-11-192645P06865Espacenet
JP 2025147176 A2025-10-066431P06865Espacenet
JP 2025529142 A2025-09-046582P06865Espacenet
WO 2025181336 A12025-09-0491P06865Espacenet
JP 2025111747 A2025-07-30149P06865Espacenet
US 12371689 B22025-07-296582P06865Espacenet
JP 2025522877 A2025-07-171055P06865Espacenet

1 to 10 of 57

See all 57 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,029

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHEXA papersNewest fiscal year
P30ES010126UNC Center for Environmental Health and Susceptibility62025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions52025
P20GM121176Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.42025
ZIADK056016Sphingolipid Biology of Neurodegeneration42025
ZIAHG200409Pathogenesis Informs Therapy for Glycosphingolipid and Glycoprotein Disorders42025
P30AG062422New Approaches to Dementia Heterogeneity32025
P30CA016672Cancer Center Support Grant32025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
P30DK020579Diabetes Research Center32025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital32025

1 to 10 of 1,029Source NIH's project files

See all 1,029 nih grants

Papers1,522

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Modeling Tay-Sachs Disease in Astrocyte-like Cells Reveals Significant Changes in the Transcriptomic Profile.Int J Mol Sci202642511849PubTator, text miningPubMed
Late-Onset Tay-Sachs Disease With SMALED-Like Muscle MRI Pattern Despite a Distinct Clinical Phenotype.J Peripher Nerv Syst202642466981PubTator, text miningPubMed
Clinical Utility of Rapid Whole-Genome Sequencing in Hospitalized Adults With Unexplained Neurologic Presentations.Neurology202642302220PubTator, text miningPubMed
Rare-Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease.Mov Disord202642272075PubTator, text miningPubMed
An example for potentially underrated causes of recessive disease in the Greater Middle East: integrative long-read genome and transcriptome sequencing pinpoint a deep-intronic homozygous HEXB candidate founder variant in GM2-gangliosidosis.
Hum Genomics202642271533PubTator, text miningPubMed
C4BP occludes the non-opsonic interaction of Neisseria gonorrhoeae with human neutrophil CEACAMs.Infect Immun202642267928PubTator, text miningPubMed
An Enzyme-Responsive Gd(III) MRI Probe for Visualizing β-Hexosaminidase A Activity.ACS Sens202642247632PubTator, text miningPubMed
The competition between splicing and 3' processing shapes the human transcriptome.Genes Dev202642140670PubTator, text miningPubMed
Diagnostic Dilemma in an Infant With Sound-Triggered Motor Events: Reflex Epilepsy Versus Exaggerated Startle-A Case Report.Clin Case Rep202642022979PubTator, text miningPubMed
The EGR1/ZFP36 axis governs glycosphingolipid metabolic reprogramming in monocyte-derived macrophages in guillain-barré syndrome.Neurotherapeutics202641916145PubTator, text miningPubMed

1 to 10 of 1,522

See all 1,522 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3073

GET https://conductscience.org/api/genes/v1/3073/patents?page=2