Gene · 3073
HEXA: hexosaminidase subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HEXA: hexosaminidase subunit alpha. Genes, record 3073. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3073
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P06865 | Beta-hexosaminidase subunit alpha | 529 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents57
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026094091 A | 2026-06-09 | 20 | P06865 | Espacenet |
| JP 2026067851 A | 2026-04-21 | 279 | P06865 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 49027 | P06865 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2645 | P06865 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6431 | P06865 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6582 | P06865 | Espacenet |
| WO 2025181336 A1 | 2025-09-04 | 91 | P06865 | Espacenet |
| JP 2025111747 A | 2025-07-30 | 149 | P06865 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6582 | P06865 | Espacenet |
| JP 2025522877 A | 2025-07-17 | 1055 | P06865 | Espacenet |
1 to 10 of 57
See all 57 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,029
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HEXA papers | Newest fiscal year |
|---|---|---|---|
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 6 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 5 | 2025 |
| P20GM121176 | Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2. | 4 | 2025 |
| ZIADK056016 | Sphingolipid Biology of Neurodegeneration | 4 | 2025 |
| ZIAHG200409 | Pathogenesis Informs Therapy for Glycosphingolipid and Glycoprotein Disorders | 4 | 2025 |
| P30AG062422 | New Approaches to Dementia Heterogeneity | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 3 | 2025 |
| P30DK020579 | Diabetes Research Center | 3 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 3 | 2025 |
1 to 10 of 1,029Source NIH's project files
See all 1,029 nih grantsPapers1,522
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Modeling Tay-Sachs Disease in Astrocyte-like Cells Reveals Significant Changes in the Transcriptomic Profile. | Int J Mol Sci | 2026 | 42511849 | PubTator, text mining | PubMed |
| Late-Onset Tay-Sachs Disease With SMALED-Like Muscle MRI Pattern Despite a Distinct Clinical Phenotype. | J Peripher Nerv Syst | 2026 | 42466981 | PubTator, text mining | PubMed |
| Clinical Utility of Rapid Whole-Genome Sequencing in Hospitalized Adults With Unexplained Neurologic Presentations. | Neurology | 2026 | 42302220 | PubTator, text mining | PubMed |
| Rare-Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease. | Mov Disord | 2026 | 42272075 | PubTator, text mining | PubMed |
An example for potentially underrated causes of recessive disease in the Greater Middle East: integrative long-read genome and transcriptome sequencing pinpoint a deep-intronic homozygous HEXB candidate founder variant in GM2-gangliosidosis. | Hum Genomics | 2026 | 42271533 | PubTator, text mining | PubMed |
| C4BP occludes the non-opsonic interaction of Neisseria gonorrhoeae with human neutrophil CEACAMs. | Infect Immun | 2026 | 42267928 | PubTator, text mining | PubMed |
| An Enzyme-Responsive Gd(III) MRI Probe for Visualizing β-Hexosaminidase A Activity. | ACS Sens | 2026 | 42247632 | PubTator, text mining | PubMed |
| The competition between splicing and 3' processing shapes the human transcriptome. | Genes Dev | 2026 | 42140670 | PubTator, text mining | PubMed |
| Diagnostic Dilemma in an Infant With Sound-Triggered Motor Events: Reflex Epilepsy Versus Exaggerated Startle-A Case Report. | Clin Case Rep | 2026 | 42022979 | PubTator, text mining | PubMed |
| The EGR1/ZFP36 axis governs glycosphingolipid metabolic reprogramming in monocyte-derived macrophages in guillain-barré syndrome. | Neurotherapeutics | 2026 | 41916145 | PubTator, text mining | PubMed |
1 to 10 of 1,522
See all 1,522 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3073
GET https://conductscience.org/api/genes/v1/3073/patents?page=2