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HFE: homeostatic iron regulator

1 protein, 89 patents, 0 drugs, 0 trials, 2,466 NIH grants and 5,137 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHFEHGNC
Namehomeostatic iron regulatorHGNC
NCBI Gene ID3077NCBI Gene
HGNC IDHGNC:4886HGNC
EnsemblENSG00000010704NCBI Gene
AliasesHFE1, HH, HLA-H, MVCD7, TFQTL2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q30201Hereditary hemochromatosis protein3482Ensembl, GeneID, HGNCUniProt

Patents 89

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21144Q30201Espacenet
EP 4650780 A22025-11-1914092Q30201Espacenet
JP 2025169942 A2025-11-141044Q30201Espacenet
EP 4640849 A22025-10-292547Q30201Espacenet
EP 4641201 A22025-10-2916418Q30201Espacenet
EP 4641202 A22025-10-29890Q30201Espacenet
EP 4641203 A22025-10-29498Q30201Espacenet
JP 2025529142 A2025-09-041941Q30201Espacenet
US 12371689 B22025-07-291941Q30201Espacenet
JP 2025519096 A2025-06-242547Q30201Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2466

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA062203Cancer Center Support Grant322,025NIH's project files
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal142,025NIH's project files
P30DK063491Diabetes Research Center (DRC)132,025NIH's project files
U01HG006379EHR-based Genomic Discovery and Implementation [Funded Extension]102,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award82,025NIH's project files
R01DK095112Regulatory Role of Transferrin in Erythropoiesis and Iron Metabolism72,025NIH's project files
R01ES013744Stress-Air Pollution Interactions and Adolescent Neurobehavior72,025NIH's project files
ZIAHL006001Framingham Project/Levy72,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)62,025NIH's project files
P30DK034989Yale Liver Center62,025NIH's project files

Papers 5137

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42798770PubTator, text miningPubMed
42794286PubTator, text miningPubMed
42764193PubTator, text miningPubMed
42763343PubTator, text miningPubMed
42656915PubTator, text miningPubMed
42650145PubTator, text miningPubMed
42606513PubTator, text miningPubMed
42572894PubTator, text miningPubMed
42561706PubTator, text miningPubMed
42559859PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license