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HGF: hepatocyte growth factor

1 protein, 395 patents, 2 drugs, 27 trials, 11,525 NIH grants and 34,808 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHGFHGNC
Namehepatocyte growth factorHGNC
NCBI Gene ID3082NCBI Gene
HGNC IDHGNC:4893HGNC
EnsemblENSG00000019991NCBI Gene
AliasesDFNB39, F-TCF, HGFB, HPTA, SFNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P14210Hepatocyte growth factor72836Ensembl, GeneID, HGNCUniProt

Patents 395

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4810029 A12026-09-23109P14210Espacenet
EP 4810030 A12026-09-231P14210Espacenet
EP 4810609 A12026-09-232P14210Espacenet
JP 2026500184 A2026-01-0611P14210Espacenet
JP 2025181979 A2025-12-111P14210Espacenet
EP 4660300 A12025-12-105P14210Espacenet
WO 2025250495 A12025-12-0418P14210Espacenet
JP 2025538460 A2025-11-282P14210Espacenet
EP 4650780 A22025-11-19556P14210Espacenet
JP 2025169942 A2025-11-141058P14210Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
FICLATUZUMABCHEMBL1743018Hepatocyte growth factor inhibitorINHIBITORChEMBL
RILOTUMUMABCHEMBL1743063Hepatocyte growth factor inhibitorINHIBITORChEMBL

Trials 27

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06064877FICLATUZUMABPHASE3ClinicalTrials.gov
NCT04100330FICLATUZUMABPHASE2ClinicalTrials.gov
NCT03422536FICLATUZUMABPHASE22023-07-19ClinicalTrials.gov
NCT03013998FICLATUZUMABPHASE1/PHASE2ClinicalTrials.gov
NCT02926638RILOTUMUMABPHASE2/PHASE32020-03-19ClinicalTrials.gov
NCT02318368FICLATUZUMABPHASE22020-10-22ClinicalTrials.gov
NCT02277197FICLATUZUMABPHASE1ClinicalTrials.gov
NCT02277184FICLATUZUMABPHASE1ClinicalTrials.gov
NCT02154490RILOTUMUMAB2023-01-31ClinicalTrials.gov
NCT02137343RILOTUMUMABPHASE3ClinicalTrials.gov

NIH grants 11525

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1932,025NIH's project files
P30CA008748Cancer Center Support Grant1012,025NIH's project files
P30CA047904Cancer Center Support Grant412,025NIH's project files
P30CA006973Regional Oncology Research Center382,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support332,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award322,025NIH's project files
P30DK034989Yale Liver Center262,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT252,025NIH's project files
P30CA033572Cancer Center Support Grant252,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant232,025NIH's project files

Papers 34808

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826660PubTator, text miningPubMed
42825082PubTator, text miningPubMed
42822803PubTator, text miningPubMed
42819705PubTator, text miningPubMed
42817738PubTator, text miningPubMed
42809553PubTator, text miningPubMed
42808256PubTator, text miningPubMed
42799794PubTator, text miningPubMed
42794696PubTator, text miningPubMed
42794437PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license