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NRG1: neuregulin 1

1 protein, 106 patents, 0 drugs, 0 trials, 4,249 NIH grants and 7,203 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNRG1HGNC
Nameneuregulin 1HGNC
NCBI Gene ID3084NCBI Gene
HGNC IDHGNC:7997HGNC
EnsemblENSG00000157168NCBI Gene
AliasesARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDFNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q02297Pro-neuregulin-1, membrane-bound isoform64011Ensembl, GeneID, HGNCUniProt

Patents 106

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4806989 A22026-09-1617Q02297Espacenet
EP 4650780 A22025-11-1911834Q02297Espacenet
JP 2025169942 A2025-11-141178Q02297Espacenet
JP 2025169942 A2025-11-141184Q02297Espacenet
EP 4641201 A22025-10-2912610Q02297Espacenet
JP 2025147176 A2025-10-069521Q02297Espacenet
JP 2025143396 A2025-10-01232Q02297Espacenet
WO 2025188180 A12025-09-12162Q02297Espacenet
JP 2025529142 A2025-09-042900Q02297Espacenet
JP 2025529142 A2025-09-047177Q02297Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 4249

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant612,025NIH's project files
P30CA016672Cancer Center Support Grant502,025NIH's project files
P30CA056036Translational Research in Cancer112,025NIH's project files
P30CA047904Cancer Center Support Grant92,025NIH's project files
P30CA093373Cancer Center Support Grant P3092,025NIH's project files
R01MH071316Rac-GEF signaling in dendritic spines92,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant82,025NIH's project files
P30CA016058Cancer Center Support Grant82,025NIH's project files
P30CA068485Cancer Center Support Grant82,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award82,025NIH's project files

Papers 7203

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818202PubTator, text miningPubMed
42792970PubTator, text miningPubMed
42786848PubTator, text miningPubMed
42782805PubTator, text miningPubMed
42777287PubTator, text miningPubMed
42763821PubTator, text miningPubMed
42737745PubTator, text miningPubMed
42723803PubTator, text miningPubMed
42719024PubTator, text miningPubMed
42717886PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license