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Gene · 30849

PIK3R4: phosphoinositide-3-kinase regulatory subunit 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PIK3R4: phosphoinositide-3-kinase regulatory subunit 4. Genes, record 30849. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/30849

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Gene

Symbol
PIK3R4
HGNC
Name
phosphoinositide-3-kinase regulatory subunit 4
HGNC
NCBI Gene ID
30849
NCBI Gene
HGNC ID
HGNC:8982
HGNC
Ensembl
ENSG00000196455
NCBI Gene
Aliases
VPS15, p150
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99570Phosphoinositide 3-kinase regulatory subunit 41,35813Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-197342Q99570Espacenet
EP 4641201 A22025-10-297288Q99570Espacenet
JP 2025517969 A2025-06-127288Q99570Espacenet
JP 2025517970 A2025-06-127342Q99570Espacenet
US 11564998 B22023-01-315908Q99570Espacenet
US 11446398 B22022-09-2063167Q99570Espacenet
JP 2022524081 A2022-04-27166138Q99570Espacenet
US 11078247 B22021-08-038486Q99570Espacenet
WO 2020043864 A12020-03-051843Q99570Espacenet
US 10463751 B22019-11-055908Q99570Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants979

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePIK3R4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
R01NS060123Neuronal Autophagy: a Cell-Autonomous Protection Mechanism82025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital72025
R35GM131919The mechanism and regulation of autophagy62025
P30CA016520Abramson Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P40OD010440Caenorhabditis Genetics Center32025
R01AG038664Regulation of the Autophagy Pathway with Age and in Long-lived Animals32025
R01CA126792Autophagy and Pro-metastatic Differentiation32025
R01HL091469Cysteine oxidation in the heart32025

1 to 10 of 979Source NIH's project files

See all 979 nih grants

Papers1,576

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The malaria parasite Plasmodium falciparum Vps15 is a Phosphatidylinositol 3-kinase interactor important for host-cell cytosol delivery to the food vacuole and apicoplast and mitochondrion dynamics.PLoS Pathog202642611934PubTator, text miningPubMed
A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution.Elife202642207670PubTator, text miningPubMed
Autophagy-centered gene networks reveal prognostic biomarkers and therapeutic targets in esophageal cancer.Discov Oncol202642204123PubTator, text miningPubMed
Genome-wide association study links COL6A6 and PIK3R4 to delayed cerebral ischaemia.Brain202642189192PubTator, text miningPubMed
Nanoparticles-based phototherapy systems: molecular mechanisms and clinical applications.Signal Transduct Target Ther202641839827PubTator, text miningPubMed
Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides.Cancer Med202641811763PubTator, text miningPubMed
Beyond muscle weakness: pathogenesis of sepsis-induced myopathy and its management.Open Med (Wars)202641798907PubTator, text miningPubMed
Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies.Front Cell Neurosci202641788195PubTator, text miningPubMed
Unravelling the Pathogenesis of Heart Failure with Preserved Ejection Fraction: The Pivotal Role of Autophagy and Endoplasmic Reticulum Stress.Eur Cardiol202641766770PubTator, text miningPubMed
Exosomes as Specific Vehicles for Delivery of Combination Therapies for Inhibiting Autophagy and Inducing Apoptosis in MYCN-Amplified Neuroblastoma Displaying Gut Dysbiosis: Current Challenges and Future Opportunities.
Brain Sci202641750126PubTator, text miningPubMed

1 to 10 of 1,576

See all 1,576 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/30849

GET https://conductscience.org/api/genes/v1/30849/patents?page=2