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HIF1A: hypoxia inducible factor 1 subunit alpha

1 protein, 236 patents, 0 drugs, 0 trials, 21,825 NIH grants and 85,928 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHIF1AHGNC
Namehypoxia inducible factor 1 subunit alphaHGNC
NCBI Gene ID3091NCBI Gene
HGNC IDHGNC:4910HGNC
EnsemblENSG00000100644NCBI Gene
AliasesHIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q16665Hypoxia-inducible factor 1-alpha82625Ensembl, GeneID, HGNCUniProt

Patents 236

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-196321Q16665Espacenet
EP 4641201 A22025-10-296081Q16665Espacenet
JP 2025147176 A2025-10-0615084Q16665Espacenet
JP 2025147176 A2025-10-0616542Q16665Espacenet
JP 2025517969 A2025-06-126081Q16665Espacenet
JP 2025517970 A2025-06-126321Q16665Espacenet
KR 1020250037510 A2025-03-171Q16665Espacenet
JP 2025028160 A2025-02-2815084Q16665Espacenet
JP 2025028160 A2025-02-2816542Q16665Espacenet
JP 2025013347 A2025-01-2435Q16665Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 21825

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant3922,025NIH's project files
P30CA008748Cancer Center Support Grant2022,025NIH's project files
P30CA006973Regional Oncology Research Center882,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award762,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant702,025NIH's project files
P30CA016087Cancer Center Support Grant632,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program582,025NIH's project files
P30CA016058Cancer Center Support Grant582,025NIH's project files
P30CA047904Cancer Center Support Grant522,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center522,025NIH's project files

Papers 85928

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826856PubTator, text miningPubMed
42825943PubTator, text miningPubMed
42825905PubTator, text miningPubMed
42825501PubTator, text miningPubMed
42824375PubTator, text miningPubMed
42823414PubTator, text miningPubMed
42821803PubTator, text miningPubMed
42820287PubTator, text miningPubMed
42819788PubTator, text miningPubMed
42819154PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license