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HK2: hexokinase 2

1 protein, 62 patents, 0 drugs, 0 trials, 3,976 NIH grants and 10,365 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHK2HGNC
Namehexokinase 2HGNC
NCBI Gene ID3099NCBI Gene
HGNC IDHGNC:4923HGNC
EnsemblENSG00000159399NCBI Gene
AliasesHKII, HXK2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P52789Hexokinase-29174Ensembl, GeneID, HGNCUniProt

Patents 62

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449023P52789Espacenet
JP 2026004568 A2026-01-1449025P52789Espacenet
EP 4650780 A22025-11-193436P52789Espacenet
EP 4641201 A22025-10-293015P52789Espacenet
WO 2025192110 A2025-09-183P52789Espacenet
JP 2025517969 A2025-06-123015P52789Espacenet
JP 2025517970 A2025-06-123436P52789Espacenet
JP 2025511977 A2025-04-165P52789Espacenet
EP 4518874 A12025-03-125P52789Espacenet
JP 2025032204 A2025-03-1129587P52789Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3976

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant952,025NIH's project files
P50CA092629SPORE in Prostate Cancer952,025NIH's project files
P30CA016672Cancer Center Support Grant492,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program162,025NIH's project files
P30CA016042Cancer Center Support Grant162,025NIH's project files
P30CA006973Regional Oncology Research Center142,025NIH's project files
R01CA090764PI3K/PTEN/Akt signaling and the genesis of cancer132,025NIH's project files
P30CA016087Cancer Center Support Grant112,025NIH's project files
P30CA086862Cancer Center Support Grant112,025NIH's project files
R01CA051497Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis102,025NIH's project files

Papers 10365

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826094PubTator, text miningPubMed
42821475PubTator, text miningPubMed
42821420PubTator, text miningPubMed
42820640PubTator, text miningPubMed
42811626PubTator, text miningPubMed
42810878PubTator, text miningPubMed
42810159PubTator, text miningPubMed
42807844PubTator, text miningPubMed
42802226PubTator, text miningPubMed
42800206PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license