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ACACA: acetyl-CoA carboxylase alpha

1 protein, 33 patents, 4 drugs, 19 trials, 4,954 NIH grants and 9,914 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolACACAHGNC
Nameacetyl-CoA carboxylase alphaHGNC
NCBI Gene ID31NCBI Gene
HGNC IDHGNC:84HGNC
EnsemblENSG00000278540NCBI Gene
AliasesACAC, ACACAD, ACACalpha, ACC, ACC-alpha, ACC1, ACCA, ACCalpha, Acac1, hACC1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13085Acetyl-CoA carboxylase 12,34610Ensembl, GeneID, HGNCUniProt

Patents 33

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1918342Q13085Espacenet
JP 2025517970 A2025-06-1218342Q13085Espacenet
JP 2025062604 A2025-04-141259Q13085Espacenet
JP 2025062604 A2025-04-141272Q13085Espacenet
JP 2024123008 A2024-09-104734Q13085Espacenet
US 11884940 B22024-01-3054Q13085Espacenet
JP 2022141755 A2022-09-29351Q13085Espacenet
US 11446398 B22022-09-201259Q13085Espacenet
US 11446398 B22022-09-201272Q13085Espacenet
WO 2022131114 A2022-06-2335Q13085Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CLESACOSTATCHEMBL4567446Acetyl-CoA carboxylase inhibitorINHIBITORChEMBL
FIRSOCOSTATCHEMBL3407547Acetyl-CoA carboxylase negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
OLUMACOSTAT GLASARETILCHEMBL3989947Acetyl-CoA carboxylase inhibitorINHIBITORChEMBL
PF-05175157CHEMBL3359265Acetyl-CoA carboxylase inhibitorINHIBITORChEMBL

Trials 19

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04971785FIRSOCOSTATPHASE22025-11-26ClinicalTrials.gov
NCT04399538CLESACOSTATPHASE22023-04-13ClinicalTrials.gov
NCT04395950CLESACOSTATPHASE1ClinicalTrials.gov
NCT04321031CLESACOSTATPHASE22025-03-21ClinicalTrials.gov
NCT03987074FIRSOCOSTATPHASE22021-07-15ClinicalTrials.gov
NCT03776175CLESACOSTATPHASE22020-09-23ClinicalTrials.gov
NCT03449446FIRSOCOSTATPHASE22020-12-03ClinicalTrials.gov
NCT03248882CLESACOSTATPHASE22020-03-10ClinicalTrials.gov
NCT03127956OLUMACOSTAT GLASARETILPHASE32019-02-05ClinicalTrials.gov
NCT03073486OLUMACOSTAT GLASARETILPHASE32019-02-05ClinicalTrials.gov

NIH grants 4954

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant722,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes252,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)232,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award212,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program172,025NIH's project files
P30CA008748Cancer Center Support Grant142,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)142,025NIH's project files
P30DK026743UCSF Liver Center142,025NIH's project files
P30DK045735Yale Diabetes Research Center142,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant102,025NIH's project files

Papers 9914

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826800PubTator, text miningPubMed
42826791PubTator, text miningPubMed
42818361PubTator, text miningPubMed
42815682PubTator, text miningPubMed
42800684PubTator, text miningPubMed
42795589PubTator, text miningPubMed
42762975PubTator, text miningPubMed
42749776PubTator, text miningPubMed
42737695PubTator, text miningPubMed
42724239PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license