Gene · 3108
HLA-DMA: major histocompatibility complex, class II, DM alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HLA-DMA: major histocompatibility complex, class II, DM alpha. Genes, record 3108. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3108
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P28067 | HLA class II histocompatibility antigen, DM alpha chain | 261 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents77
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 9534 | P28067 | Espacenet |
| WO 2025228986 A1 | 2025-11-06 | 64 | P28067 | Espacenet |
| EP 4644537 A1 | 2025-11-05 | 64 | P28067 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 541 | P28067 | Espacenet |
| EP 4641203 A2 | 2025-10-29 | 280 | P28067 | Espacenet |
| JP 2025517967 A | 2025-06-12 | 280 | P28067 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9534 | P28067 | Espacenet |
| KR 1020250017230 A | 2025-02-04 | 280 | P28067 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 541 | P28067 | Espacenet |
| US 12146238 B2 | 2024-11-19 | 260 | P28067 | Espacenet |
1 to 10 of 77
See all 77 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,799
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HLA-DMA papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 13 | 2025 |
| T32AI007290 | Molecular and Cellular Immunobiology | 11 | 2025 |
| P30CA138313 | Medical University of South Carolina - Cancer Center Support Grant | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| T32AI007247 | Cellular and Molecular Mechanisms of Immune Inflammatory Reactions | 4 | 2025 |
| ZIABC009404 | Regulation of MHC Class II Trafficking in Antigen Presenting Cells | 4 | 2025 |
| P01AI039671 | Costimulatory Mechanisms of Autoimmunity | 3 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 3 | 2025 |
| P30CA014599 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,799Source NIH's project files
See all 1,799 nih grantsPapers2,126
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| H. pylori Outer Membrane Protein Antibody Response, MHC/HLA-DMA Methylation, and Gastric Cancer Risk: A Multi-Layer Evidence Integration Study Using Mendelian Randomization. | Genes (Basel) | 2026 | 42793018 | PubTator, text mining | PubMed |
| Iron Dyshomeostasis and Divergent Antigen Presentation Remodeling in Bronchiectasis: A Dual-Dataset Transcriptomic Analysis. | J Inflamm Res | 2026 | 42670432 | PubTator, text mining | PubMed |
| Identification of PD-1-Related Genes as Prognostic Biomarkers in Lung Adenocarcinoma. | Hum Mutat | 2026 | 42643623 | PubTator, text mining | PubMed |
| Identification of Predictive Biomarkers for Chemoradiotherapy Response in Rectal Cancer. | JCO Precis Oncol | 2026 | 42566730 | PubTator, text mining | PubMed |
| Respiratory syncytial virus inhibits type I interferon signaling to maintain HLA-DM expression in CD1c+ dendritic cells. | iScience | 2026 | 42555398 | PubTator, text mining | PubMed |
| Transcriptomic signatures and immune microenvironment of acute rejection after heart transplantation: an integrated bioinformatics analysis. | Front Cardiovasc Med | 2026 | 42267100 | PubTator, text mining | PubMed |
| Glatiramer Acetate Therapy Induces DNA Methylation Changes in Immune Cells of Multiple Sclerosis Patients: A Pilot Study. | Int J Mol Sci | 2026 | 42196591 | PubTator, text mining | PubMed |
| Molecular profiling of sacral chordomas through methylation, spatial transcriptomics and multiplexed immunofluorescence. | ESMO Rare Cancers | 2026 | 41924303 | PubTator, text mining | PubMed |
| Dynamic Allostery in T Cell Receptor Specificity: A Role for Peptides and MHC Polymorphisms in Allosterically Tuning Immune Recognition. | Bioessays | 2026 | 41879488 | PubTator, text mining | PubMed |
| Anti-HLA antibodies in lung transplantation: diagnostic pitfalls and future directions. | Eur Respir Rev | 2026 | 41813012 | PubTator, text mining | PubMed |
1 to 10 of 2,126
See all 2,126 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3108
GET https://conductscience.org/api/genes/v1/3108/patents?page=2