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Gene · 3108

HLA-DMA: major histocompatibility complex, class II, DM alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HLA-DMA: major histocompatibility complex, class II, DM alpha. Genes, record 3108. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3108

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Gene

Symbol
HLA-DMA
HGNC
Name
major histocompatibility complex, class II, DM alpha
HGNC
NCBI Gene ID
3108
NCBI Gene
HGNC ID
HGNC:4934
HGNC
Ensembl
ENSG00000204257
NCBI Gene
Aliases
D6S222E, DMA, HLADM, RING6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P28067HLA class II histocompatibility antigen, DM alpha chain2614Ensembl, GeneID, HGNC

Source UniProt

Patents77

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199534P28067Espacenet
WO 2025228986 A12025-11-0664P28067Espacenet
EP 4644537 A12025-11-0564P28067Espacenet
EP 4641202 A22025-10-29541P28067Espacenet
EP 4641203 A22025-10-29280P28067Espacenet
JP 2025517967 A2025-06-12280P28067Espacenet
JP 2025517970 A2025-06-129534P28067Espacenet
KR 1020250017230 A2025-02-04280P28067Espacenet
KR 1020250017231 A2025-02-04541P28067Espacenet
US 12146238 B22024-11-19260P28067Espacenet

1 to 10 of 77

See all 77 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,799

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHLA-DMA papersNewest fiscal year
P30CA008748Cancer Center Support Grant132025
T32AI007290Molecular and Cellular Immunobiology112025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant72025
T32AI007247Cellular and Molecular Mechanisms of Immune Inflammatory Reactions42025
ZIABC009404Regulation of MHC Class II Trafficking in Antigen Presenting Cells42025
P01AI039671Costimulatory Mechanisms of Autoimmunity32025
P30CA014051Cancer Center Support (Core) Grant32025
P30CA014599Cancer Center Support Grant32025
P30CA016056Roswell Park Cancer Center Support Grant32025

1 to 10 of 1,799Source NIH's project files

See all 1,799 nih grants

Papers2,126

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
H. pylori Outer Membrane Protein Antibody Response, MHC/HLA-DMA Methylation, and Gastric Cancer Risk: A Multi-Layer Evidence Integration Study Using Mendelian Randomization.Genes (Basel)202642793018PubTator, text miningPubMed
Iron Dyshomeostasis and Divergent Antigen Presentation Remodeling in Bronchiectasis: A Dual-Dataset Transcriptomic Analysis.J Inflamm Res202642670432PubTator, text miningPubMed
Identification of PD-1-Related Genes as Prognostic Biomarkers in Lung Adenocarcinoma.Hum Mutat202642643623PubTator, text miningPubMed
Identification of Predictive Biomarkers for Chemoradiotherapy Response in Rectal Cancer.JCO Precis Oncol202642566730PubTator, text miningPubMed
Respiratory syncytial virus inhibits type I interferon signaling to maintain HLA-DM expression in CD1c+ dendritic cells.iScience202642555398PubTator, text miningPubMed
Transcriptomic signatures and immune microenvironment of acute rejection after heart transplantation: an integrated bioinformatics analysis.Front Cardiovasc Med202642267100PubTator, text miningPubMed
Glatiramer Acetate Therapy Induces DNA Methylation Changes in Immune Cells of Multiple Sclerosis Patients: A Pilot Study.Int J Mol Sci202642196591PubTator, text miningPubMed
Molecular profiling of sacral chordomas through methylation, spatial transcriptomics and multiplexed immunofluorescence.ESMO Rare Cancers202641924303PubTator, text miningPubMed
Dynamic Allostery in T Cell Receptor Specificity: A Role for Peptides and MHC Polymorphisms in Allosterically Tuning Immune Recognition.Bioessays202641879488PubTator, text miningPubMed
Anti-HLA antibodies in lung transplantation: diagnostic pitfalls and future directions.Eur Respir Rev202641813012PubTator, text miningPubMed

1 to 10 of 2,126

See all 2,126 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3108

GET https://conductscience.org/api/genes/v1/3108/patents?page=2