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HLA-DRB1: major histocompatibility complex, class II, DR beta 1

1 protein, 67 patents, 3 drugs, 9 trials, 7,645 NIH grants and 22,691 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHLA-DRB1HGNC
Namemajor histocompatibility complex, class II, DR beta 1HGNC
NCBI Gene ID3123NCBI Gene
HGNC IDHGNC:4948HGNC
EnsemblENSG00000196126NCBI Gene
AliasesDRB1, HLA-DR1B, HLA-DRB, SS1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01911HLA class II histocompatibility antigen, DRB1 beta chain266108Ensembl, GeneID, HGNCUniProt

Patents 67

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452433P01911Espacenet
EP 4650780 A22025-11-197738P01911Espacenet
EP 4640849 A22025-10-291164P01911Espacenet
EP 4641201 A22025-10-297786P01911Espacenet
EP 4623931 A12025-10-0129P01911Espacenet
JP 2025529142 A2025-09-041970P01911Espacenet
KR 1020250116683 A2025-08-0129P01911Espacenet
US 12371689 B22025-07-291970P01911Espacenet
JP 2025519096 A2025-06-241164P01911Espacenet
JP 2025517969 A2025-06-127786P01911Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APOLIZUMABCHEMBL2108252Human leukocyte antigen DR beta chain inhibitorINHIBITORChEMBL
LYM-1CHEMBL2109447HLA class II histocompatibility antigen, DRB1-15 beta chain otherOTHERChEMBL
PLOVAMER ACETATECHEMBL2108712HLA class II histocompatibility antigen, DRB1-15 beta chain modulatorMODULATORChEMBL

Trials 9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01963611PLOVAMER ACETATEPHASE22016-05-11ClinicalTrials.gov
NCT00089154APOLIZUMABPHASE2ClinicalTrials.gov
NCT00055783APOLIZUMABPHASE2ClinicalTrials.gov
NCT00022971APOLIZUMABPHASE1ClinicalTrials.gov
NCT00017472APOLIZUMABPHASE1ClinicalTrials.gov
NCT00014664APOLIZUMABPHASE2ClinicalTrials.gov
NCT00009776LYM-1PHASE1ClinicalTrials.gov
NCT00008021LYM-1PHASE1ClinicalTrials.gov
NCT00004101APOLIZUMABPHASE1ClinicalTrials.gov

NIH grants 7645

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
U24CA076518A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research1802,025NIH's project files
P30CA008748Cancer Center Support Grant992,025NIH's project files
P01CA018029Adult Leukemia Research Center942,025NIH's project files
P30CA015704Cancer Center Support Grant732,025NIH's project files
P30CA016672Cancer Center Support Grant642,025NIH's project files
R01DK032083Multiple Autoantigens, Multiple Epitopes of Type 1 Diabetes422,025NIH's project files
R01AR063759Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state402,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies392,025NIH's project files
R01CA100019Clinical Significance of MHC Haplotypes in HCT332,025NIH's project files
U01AI069197Hematopoietic Stem Cell And Cord Blood Transplantation322,025NIH's project files

Papers 22691

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825917PubTator, text miningPubMed
42825120PubTator, text miningPubMed
42821566PubTator, text miningPubMed
42818167PubTator, text miningPubMed
42813438PubTator, text miningPubMed
42812001PubTator, text miningPubMed
42810907PubTator, text miningPubMed
42810048PubTator, text miningPubMed
42808222PubTator, text miningPubMed
42806292PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license