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HLA-DRB4: major histocompatibility complex, class II, DR beta 4

1 protein, 34 patents, 0 drugs, 0 trials, 3,050 NIH grants and 7,136 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHLA-DRB4HGNC
Namemajor histocompatibility complex, class II, DR beta 4HGNC
NCBI Gene ID3126NCBI Gene
HGNC IDHGNC:4952HGNC
EnsemblENSG00000227357NCBI Gene
AliasesDR4, DRB4, HLA-DR4B, HLA-DRB, HLA-DRB4*NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P13762HLA class II histocompatibility antigen, DR beta 4 chain2660Ensembl, GeneID, HGNCUniProt

Patents 34

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12029782 B22024-07-09143P13762Espacenet
JP 2024063050 A2024-05-10292P13762Espacenet
JP 2024517658 A2024-04-2342P13762Espacenet
JP 2024516610 A2024-04-1642P13762Espacenet
JP 2024515707 A2024-04-1060P13762Espacenet
JP 2024515205 A2024-04-0560P13762Espacenet
JP 2023541366 A2023-10-02143P13762Espacenet
JP 2023519304 A2023-05-10136P13762Espacenet
KR 1020220160053 A2022-12-05124P13762Espacenet
US 11446398 B22022-09-2038711P13762Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3050

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01DK032083Multiple Autoantigens, Multiple Epitopes of Type 1 Diabetes472,025NIH's project files
P30DK017047Diabetes Research Center312,025NIH's project files
P01CA018029Adult Leukemia Research Center222,025NIH's project files
P30CA016672Cancer Center Support Grant182,025NIH's project files
P01AI042288Immune Function and the Progression to Type 1 Diabetes172,025NIH's project files
U01DK103282Type 1 Diabetes TrialNet Clinical Network Hub152,025NIH's project files
P30DK116073University of Colorado Anschutz Medical Campus DRC132,025NIH's project files
R01AI128775Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic Data122,025NIH's project files
R01DK108868Insulin specific T cell response shaped by diabetes protective MHC class II molecules122,025NIH's project files
P30DK048520Colorado Nutrition Obesity Research Center92,025NIH's project files

Papers 7136

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42806292PubTator, text miningPubMed
42661591PubTator, text miningPubMed
42647792PubTator, text miningPubMed
42620571PubTator, text miningPubMed
42563371PubTator, text miningPubMed
42498053PubTator, text miningPubMed
42461131PubTator, text miningPubMed
42362493PubTator, text miningPubMed
42353635PubTator, text miningPubMed
42341485PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license