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HLA-E: major histocompatibility complex, class I, E

1 protein, 95 patents, 0 drugs, 0 trials, 2,947 NIH grants and 5,363 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHLA-EHGNC
Namemajor histocompatibility complex, class I, EHGNC
NCBI Gene ID3133NCBI Gene
HGNC IDHGNC:4962HGNC
EnsemblENSG00000204592NCBI Gene
AliasesHLA-6.2, QA1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P13747HLA class I histocompatibility antigen, alpha chain E35834Ensembl, GeneID, HGNCUniProt

Patents 95

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026222388 A12026-10-2216P13747Espacenet
EP 4801948 A12026-09-0946P13747Espacenet
EP 4743487 A12026-05-206P13747Espacenet
JP 2026503988 A2026-02-0351P13747Espacenet
EP 4683650 A22026-01-28472P13747Espacenet
JP 2026500670 A2026-01-0816P13747Espacenet
EP 4669673 A12025-12-3112P13747Espacenet
EP 4650780 A22025-11-199807P13747Espacenet
EP 4644421 A12025-11-0551P13747Espacenet
KR 1020250127134 A2025-08-2616P13747Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2947

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant372,025NIH's project files
P01CA111412NK cells, their receptors and cancer therapy332,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies242,025NIH's project files
T32AI007290Molecular and Cellular Immunobiology182,025NIH's project files
P30CA016672Cancer Center Support Grant172,025NIH's project files
U01AI069197Hematopoietic Stem Cell And Cord Blood Transplantation142,025NIH's project files
P30CA077598Cancer Center Support Grant102,025NIH's project files
P51OD011132Emory National Primate Research Center102,025NIH's project files
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro102,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award102,025NIH's project files

Papers 5363

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818344PubTator, text miningPubMed
42809069PubTator, text miningPubMed
42808109PubTator, text miningPubMed
42804096PubTator, text miningPubMed
42798230PubTator, text miningPubMed
42792643PubTator, text miningPubMed
42777954PubTator, text miningPubMed
42777043PubTator, text miningPubMed
42774728PubTator, text miningPubMed
42767769PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license