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Gene · 3134

HLA-F: major histocompatibility complex, class I, F

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HLA-F: major histocompatibility complex, class I, F. Genes, record 3134. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3134

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Gene

Symbol
HLA-F
HGNC
Name
major histocompatibility complex, class I, F
HGNC
NCBI Gene ID
3134
NCBI Gene
HGNC ID
HGNC:4963
HGNC
Ensembl
ENSG00000204642
NCBI Gene
Aliases
CDA12, HLA-5.4, HLA-CDA12, HLAF
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30511HLA class I histocompatibility antigen, alpha chain F3462Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026222388 A12026-10-2218P30511Espacenet
EP 4801948 A12026-09-0947P30511Espacenet
JP 2026500670 A2026-01-0818P30511Espacenet
EP 4650780 A22025-11-196088P30511Espacenet
EP 4641202 A22025-10-29327P30511Espacenet
EP 4641203 A22025-10-29186P30511Espacenet
JP 2025529142 A2025-09-041972P30511Espacenet
KR 1020250127134 A2025-08-2618P30511Espacenet
US 12371689 B22025-07-291972P30511Espacenet
JP 2025517967 A2025-06-12186P30511Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,180

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHLA-F papersNewest fiscal year
P30CA008748Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
U01AI090905Insights Into Immune-Related Diseases Born from Population Genomics62025
P30AI027757University of Washington/Fred Hutch Center for AIDS Research42025
P01CA018029Adult Leukemia Research Center32025
P30AI036214San Diego Center for AIDS Research (SD CFAR)32025
P30CA016056Roswell Park Cancer Center Support Grant32025
T32AI007290Molecular and Cellular Immunobiology32025
UL1TR001863Yale Clinical and Translational Science Award32025
ZIABC010791Effects of genetic polymorphism in MHC, KIR, and related loci on human disease32025

1 to 10 of 1,180Source NIH's project files

See all 1,180 nih grants

Papers1,531

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cell Type-Resolved Causal Inference and Spatial Transcriptomic Integration Reveal Immune-Specific Genetic Drivers of Autoimmune and Malignant Thyroid Disease.Int J Immunogenet202642734902PubTator, text miningPubMed
Emerging therapeutic opportunities targeting nonclassical MHC-I molecules.Trends Mol Med202642604821PubTator, text miningPubMed
Genetic Diversity and Haplotype Architecture of Non-Classical HLA Class I Genes in the Japanese Population.HLA202642576171PubTator, text miningPubMed
Application of single-cell RNA sequencing in preeclampsia.Front Glob Womens Health202642367612PubTator, text miningPubMed
Expanded Allelic Diversity of Non-Classical HLA Class I and MIC Loci Identified Using Full-Gene Hybrid Capture-Based Next-Generation Sequencing.HLA202642366455PubTator, text miningPubMed
Type I Interferon Regulation of HLA-F Expression in Human Trophoblasts During Viral Infection.Viruses202642357613PubTator, text miningPubMed
Spatial Analysis Identifies Endothelial HLA-F as a Prognostic Marker in Antibody-mediated Rejection.Transplantation202642302751PubTator, text miningPubMed
Last Licensed Non-Classical Peptide Presenter HLA-F: Its Occurrence, Immunoediting Significance, and Possible Therapeutic Implications in Renal Cell Carcinoma.Int J Mol Sci202642278594PubTator, text miningPubMed
PSD3 links autophagic flux to MHC-I-associated immune modulation in esophageal squamous cell carcinoma.Apoptosis202642149295PubTator, text miningPubMed
Nonclassical MHC-I Molecules: Emerging Therapeutic Targets in Next-Generation Immunotherapy.MedComm (2020)202642027260PubTator, text miningPubMed

1 to 10 of 1,531

See all 1,531 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3134

GET https://conductscience.org/api/genes/v1/3134/patents?page=2