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Gene · 3140

MR1: major histocompatibility complex, class I-related

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MR1: major histocompatibility complex, class I-related. Genes, record 3140. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3140

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Gene

Symbol
MR1
HGNC
Name
major histocompatibility complex, class I-related
HGNC
NCBI Gene ID
3140
NCBI Gene
HGNC ID
HGNC:4975
HGNC
Ensembl
ENSG00000153029
NCBI Gene
Aliases
HLALS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q95460Major histocompatibility complex class I-related protein 134183Ensembl, GeneID, HGNC

Source UniProt

Patents54

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4801948 A12026-09-0949Q95460Espacenet
JP 2026004568 A2026-01-1452451Q95460Espacenet
EP 4650780 A22025-11-198256Q95460Espacenet
EP 4641201 A22025-10-298437Q95460Espacenet
JP 2025147176 A2025-10-068852Q95460Espacenet
JP 2025147176 A2025-10-068853Q95460Espacenet
JP 2025147176 A2025-10-0614663Q95460Espacenet
JP 2025529142 A2025-09-042690Q95460Espacenet
JP 2025529142 A2025-09-047066Q95460Espacenet
US 12371689 B22025-07-292690Q95460Espacenet

1 to 10 of 54

See all 54 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,274

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMR1 papersNewest fiscal year
R01AI049313T cell responses to CD1-restricted lipids in tuberculosis242025
U19AI082630Durable Alteration of the Human Immune system after Infection or Immunotherapy132025
T32HL083808Multidisciplinary Research Training in Pulmonary Medicine122025
P30CA008748Cancer Center Support Grant62025
P51OD011106Wisconsin National Primate Research Center Support62025
P51OD011132Emory National Primate Research Center52025
R01AI123323Inflammation-driven T Cell Responses and their Dichotomous Effect on Host Immunity52025
R24AI059830A Xenopus Laevis Research Resource for Immunobiology52025
U54DK106846Hematopoietic stem and progenitor cell regulation for enhanced clinical efficacy52025
P30AI060354Harvard University Center for AIDS Research42025

1 to 10 of 1,274Source NIH's project files

See all 1,274 nih grants

Papers1,845

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Specific targeting of MR1-antigen complexes using nanobodies.Sci Immunol202642789664PubTator, text miningPubMed
Mucosal-Associated Invariant T Cells in Health and Disease.MedComm (2020)202642746087PubTator, text miningPubMed
Defining Functional T Cell Receptor Repertoires With Nanovial-Based Screening.Immunol Rev202642717414PubTator, text miningPubMed
Living Microbe-Driven Bioorthogonal Catalysts Enables Cytotoxin Generation, Cuproptosis and Lactate Depletion for Synergistic Tumor Therapy.ACS Nano202642689714PubTator, text miningPubMed
Adoptive MAIT cell therapy for liver cancer enhanced by multimodal modulation of immune receptors and checkpoints.Med202642685688PubTator, text miningPubMed
TNF and CD107a-dominated enhanced effector responses of CD8+ MAIT cells to Escherichia coli stimulation in patients with aplastic anemia.Cell Immunol202642667739PubTator, text miningPubMed
Reshaping bio-nano interfaces via dissolved humic substances: Metabolic priming and electron shuttling drive robust Cr(VI) detoxification by MR-1/nZVI.J Hazard Mater202642641512PubTator, text miningPubMed
Select intratumoral riboflavin-auxotrophic Enterococcus species enhance cell surface MR1 expression and MAIT TCR activation in lung cancer.Proc Natl Acad Sci U S A202642611994PubTator, text miningPubMed
Emerging therapeutic opportunities targeting nonclassical MHC-I molecules.Trends Mol Med202642604821PubTator, text miningPubMed
A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells.Chemistry202642599025PubTator, text miningPubMed

1 to 10 of 1,845

See all 1,845 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3140

GET https://conductscience.org/api/genes/v1/3140/patents?page=2