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Gene · 3145

HMBS: hydroxymethylbilane synthase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HMBS: hydroxymethylbilane synthase. Genes, record 3145. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3145

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Gene

Symbol
HMBS
HGNC
Name
hydroxymethylbilane synthase
HGNC
NCBI Gene ID
3145
NCBI Gene
HGNC ID
HGNC:4982
HGNC
Ensembl
ENSG00000256269
NCBI Gene
Aliases
ENCEP, LENCEP, PBG-D, PBGD, PORC, UPS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08397Porphobilinogen deaminase36111Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21102P08397Espacenet
JP 2026004568 A2026-01-1449531P08397Espacenet
EP 4650780 A22025-11-1919759P08397Espacenet
JP 2025525390 A2025-08-053656P08397Espacenet
US 12377136 B22025-08-051P08397Espacenet
JP 2025517970 A2025-06-1219759P08397Espacenet
US 12297285 B22025-05-133656P08397Espacenet
JP 2024521444 A2024-05-313269P08397Espacenet
KR 1020240019791 A2024-02-143258P08397Espacenet
JP 2023521663 A2023-05-25101P08397Espacenet

1 to 10 of 34

See all 34 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,237

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHMBS papersNewest fiscal year
U54DK110858Center for Iron & Heme Disorders at the University of Utah112025
P30CA008748Cancer Center Support Grant52025
P30DK034987Center for Gastrointestinal Biology and Disease52025
P30CA016087Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30DK026743UCSF Liver Center42025
P50CA186786Michigan Prostate SPORE 2025-203042025
T32GM082773T32 training grant in medical genetics.42025
P30CA014195Cancer Center Support Grant (CCSG)32025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant32025

1 to 10 of 1,237Source NIH's project files

See all 1,237 nih grants

Papers3,427

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PROTAC probe-assisted degradomics identifies SPINT2 as a candidate cellular target involved in the anti-cancer activity of Flupentixol.Bioorg Chem202642826660PubTator, text miningPubMed
Validation of Optimal Reference Genes for qRT-PCR in Adipose- and Uterine-Derived Feline Mesenchymal Stem Cells.Vet Sci202642797937PubTator, text miningPubMed
Synthesis and biological evaluation of cyanoenone- and enone-fused 4-androstene-3,17-dione derivatives against triple-negative breast cancer.Bioorg Chem202642748754PubTator, text miningPubMed
UPS-mediated P-glycoprotein regulation in Alzheimer's disease: pharmacological implications for the amyloid pathology.Mol Biol Rep202642704522PubTator, text miningPubMed
Acute Intermittent Porphyria with a Secondary Porphyria Cutanea Tarda-like Biochemical Pattern in a Patient with Co-Morbid Human Immunodeficiency Virus Infection.EJIFCC202642698978PubTator, text miningPubMed
Sex-specific signatures of fetal programming for gestational diabetes mellitus in umbilical cord: A cohort study from Tanzania.BMC Med202642629565PubTator, text miningPubMed
RIMTAC: A Novel Degrader Design Platform by Indirect VHL-Recruitment via RIPK1.J Med Chem202642417401PubTator, text miningPubMed
Limited benefit of liver transplantation in a boy with biallelic severe deficiency of hydroxymethylbilane synthase and review of prior reported cases.Mol Genet Metab Rep202642396593PubTator, text miningPubMed
Sarcopenia and Frailty in COPD: Mechanisms, Relationship with Malnutrition and Potential Therapeutic Interventions.Nutrients202642356388PubTator, text miningPubMed
A Case Report of Acute Intermittent Porphyria Accompanied by Severe Peripheral Neuropathy.Diagnostics (Basel)202642351467PubTator, text miningPubMed

1 to 10 of 3,427

See all 3,427 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3145

GET https://conductscience.org/api/genes/v1/3145/patents?page=2