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HMGB1: high mobility group box 1

1 protein, 371 patents, 1 drug, 3 trials, 8,186 NIH grants and 24,528 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHMGB1HGNC
Namehigh mobility group box 1HGNC
NCBI Gene ID3146NCBI Gene
HGNC IDHGNC:4983HGNC
EnsemblENSG00000189403NCBI Gene
AliasesDKFZp686A04236, HMG-1, HMG1, HMG3, SBP-1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P09429High mobility group protein B121513Ensembl, GeneID, HGNCUniProt

Patents 371

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4709870 A12026-03-1829P09429Espacenet
US 12539325 B22026-02-0366P09429Espacenet
JP 2026004568 A2026-01-1449080P09429Espacenet
JP 2026004568 A2026-01-1449081P09429Espacenet
JP 2026004568 A2026-01-1449084P09429Espacenet
JP 2026004568 A2026-01-1449085P09429Espacenet
EP 4663762 A22025-12-1723P09429Espacenet
JP 2025538154 A2025-11-2632P09429Espacenet
JP 2025538154 A2025-11-2645P09429Espacenet
JP 2025537168 A2025-11-142P09429Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CD24FCCHEMBL4297717High mobility group protein B1 inhibitorINHIBITORChEMBL

Trials 3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04317040CD24FCPHASE32021-10-15ClinicalTrials.gov
NCT04060407CD24FCPHASE1/PHASE2ClinicalTrials.gov
NCT03960541CD24FCPHASE22022-06-08ClinicalTrials.gov

NIH grants 8186

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant452,025NIH's project files
P30CA016672Cancer Center Support Grant422,025NIH's project files
P30CA047904Cancer Center Support Grant412,025NIH's project files
R35GM118182Molecular basis of bioelectronic medicine332,025NIH's project files
P60AA011605Molecular and Circuit Pathogenesis of Alcohol Use Disorders272,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition232,025NIH's project files
P30EY004068Core Grant for Vision Research212,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award202,025NIH's project files
T32GM008721Molecular Biology in Burns and Trauma172,025NIH's project files
P30CA016087Cancer Center Support Grant162,025NIH's project files

Papers 24528

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823398PubTator, text miningPubMed
42823086PubTator, text miningPubMed
42822681PubTator, text miningPubMed
42820914PubTator, text miningPubMed
42820044PubTator, text miningPubMed
42817917PubTator, text miningPubMed
42816842PubTator, text miningPubMed
42812611PubTator, text miningPubMed
42812529PubTator, text miningPubMed
42809427PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license