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HMGCR: 3-hydroxy-3-methylglutaryl-CoA reductase

1 protein, 84 patents, 16 drugs, 984 trials, 6,958 NIH grants and 18,393 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHMGCRHGNC
Name3-hydroxy-3-methylglutaryl-CoA reductaseHGNC
NCBI Gene ID3156NCBI Gene
HGNC IDHGNC:5006HGNC
EnsemblENSG00000113161NCBI Gene
AliasesLDLCQ3, LGMDR28, MYPLGNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P040353-hydroxy-3-methylglutaryl-coenzyme A reductase88824Ensembl, GeneID, HGNCUniProt

Patents 84

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4680234 A12026-01-212P04035Espacenet
JP 2025541179 A2025-12-1842P04035Espacenet
EP 4650780 A22025-11-193349P04035Espacenet
EP 4641201 A22025-10-292917P04035Espacenet
EP 4641202 A22025-10-29168P04035Espacenet
EP 4630459 A12025-10-1542P04035Espacenet
WO 2025188589 A12025-09-12104P04035Espacenet
JP 2025529142 A2025-09-041975P04035Espacenet
US 12371689 B22025-07-291975P04035Espacenet
JP 2025517969 A2025-06-122917P04035Espacenet

Drugs 16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATORVASTATINCHEMBL1487HMG-CoA reductase inhibitorINHIBITORChEMBL
ATORVASTATIN CALCIUMCHEMBL393220HMG-CoA reductase inhibitorINHIBITORChEMBL
CERIVASTATINCHEMBL1477HMG-CoA reductase inhibitorINHIBITORChEMBL
CERIVASTATIN SODIUMCHEMBL1200563HMG-CoA reductase inhibitorINHIBITORChEMBL
FLUVASTATINCHEMBL2220442HMG-CoA reductase inhibitorINHIBITORChEMBL
FLUVASTATIN SODIUMCHEMBL2218894HMG-CoA reductase inhibitorINHIBITORChEMBL
LOVASTATINCHEMBL503HMG-CoA reductase inhibitorINHIBITORChEMBL
PITAVASTATINCHEMBL1201753HMG-CoA reductase inhibitorINHIBITORChEMBL
PITAVASTATIN CALCIUMCHEMBL1237061HMG-CoA reductase inhibitorINHIBITORChEMBL
PITAVASTATIN MAGNESIUMCHEMBL3989923HMG-CoA reductase inhibitorINHIBITORChEMBL

Trials 984

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07600385ROSUVASTATINPHASE3ClinicalTrials.gov
NCT07564726ROSUVASTATINPHASE3ClinicalTrials.gov
NCT07549958PITAVASTATINPHASE1ClinicalTrials.gov
NCT07549932ATORVASTATINClinicalTrials.gov
NCT07530640ATORVASTATINPHASE3ClinicalTrials.gov
NCT07524101PITAVASTATINClinicalTrials.gov
NCT07524101ATORVASTATINClinicalTrials.gov
NCT07474649ATORVASTATINPHASE3ClinicalTrials.gov
NCT07474649ROSUVASTATINPHASE3ClinicalTrials.gov
NCT07460960PITAVASTATINPHASE2ClinicalTrials.gov

NIH grants 6958

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAAR041203Muscle Disease Unit452,025NIH's project files
P30CA008748Cancer Center Support Grant242,025NIH's project files
P30CA016672Cancer Center Support Grant232,025NIH's project files
P30DK063491Diabetes Research Center (DRC)212,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award192,025NIH's project files
ZIAES101074Environmental/genetic Risk Factors and Pathogenesis of Autoimmune Disease152,025NIH's project files
P30DK026743UCSF Liver Center142,025NIH's project files
UL1TR001881UCLA Clinical and Translational Science Institute122,025NIH's project files
P30AR070254Johns Hopkins Rheumatic Diseases Resource-based Core Center (Johns Hopkins RDRCC)112,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT112,025NIH's project files

Papers 18393

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821537PubTator, text miningPubMed
42792827PubTator, text miningPubMed
42786572PubTator, text miningPubMed
42782482PubTator, text miningPubMed
42781288PubTator, text miningPubMed
42774745PubTator, text miningPubMed
42772435PubTator, text miningPubMed
42767467PubTator, text miningPubMed
42765522PubTator, text miningPubMed
42763787PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license