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Gene · 3157

HMGCS1: 3-hydroxy-3-methylglutaryl-CoA synthase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HMGCS1: 3-hydroxy-3-methylglutaryl-CoA synthase 1. Genes, record 3157. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3157

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Gene

Symbol
HMGCS1
HGNC
Name
3-hydroxy-3-methylglutaryl-CoA synthase 1
HGNC
NCBI Gene ID
3157
NCBI Gene
HGNC ID
HGNC:5007
HGNC
Ensembl
ENSG00000112972
NCBI Gene
Aliases
CMYO28, HMGCS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q01581Hydroxymethylglutaryl-CoA synthase, cytoplasmic5202Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435701Q01581Espacenet
JP 2026004568 A2026-01-1435702Q01581Espacenet
EP 4650780 A22025-11-195450Q01581Espacenet
EP 4641201 A22025-10-295059Q01581Espacenet
EP 4641202 A22025-10-294963Q01581Espacenet
JP 2025517969 A2025-06-125059Q01581Espacenet
JP 2025517970 A2025-06-125450Q01581Espacenet
JP 2025062604 A2025-04-14215Q01581Espacenet
JP 2025062604 A2025-04-14216Q01581Espacenet
JP 2025032204 A2025-03-1129612Q01581Espacenet

1 to 10 of 58

See all 58 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,068

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHMGCS1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P30CA010815Consolidated Basic Cancer Research Program52025
P30DK063491Diabetes Research Center (DRC)52025
P01HL116263HDL Function in Human Disease32025
P30CA016059Massey Cancer Center - Cancer Center Support Grant32025
P30CA016359Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30CA093373Cancer Center Support Grant P3032025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
ZIABC011176Functions of KSHV microRNAs and circular RNAs32025

1 to 10 of 1,068Source NIH's project files

See all 1,068 nih grants

Papers1,567

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
3D-printed niche-matched GelMA-dECM bioinks rewire lipid metabolic reprogramming and chemosensitization in pancreatic ductal adenocarcinoma.Biomaterials202742633729PubTator, text miningPubMed
Multi-omics integration reveals tissue-specific biosynthesis of sesquiterpenoids in the medicinal plant Eupatorium lindleyanum.PLoS One202642821537PubTator, text miningPubMed
Exploring the role of statin interventions on cognitive function by Mendelian randomization study.J Alzheimers Dis Rep202642818896PubTator, text miningPubMed
Natural product-based therapeutic strategies against Leishmania: mechanistic insights and emerging host-directed approaches.Front Microbiol202642746096PubTator, text miningPubMed
Targeting lipid metabolism-associated lncHMGCS1 suppressed cell proliferation and restored intracellular lipid homeostasis by regulating ACSL3 in gastric cancer.Eur J Pharmacol202642722057PubTator, text miningPubMed
SIRT6 Mediates Sterol-Dependent Feedback Regulation of Cholesterol Biosynthetic Genes in Hepatocytes.Biomol Ther (Seoul)202642676034PubTator, text miningPubMed
SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation.Proc Natl Acad Sci U S A202642636358PubTator, text miningPubMed
Dysregulated Acetate Metabolism and Cholesterol Biosynthesis in Cumulus Cells of Women with Polycystic Ovary Syndrome.Cell J202642634992PubTator, text miningPubMed
Unconventional role of hydroxymethylglutaryl-CoA synthase 1 in driving pathogenic TH17 cell immunity and autoimmune diseases.Sci Adv202642616895PubTator, text miningPubMed
Arteannuin B Induces Ferroptosis in Colorectal Cancer Cells via GDF15/HMGCS1/GPX4 Axis.J Cancer202642524207PubTator, text miningPubMed

1 to 10 of 1,567

See all 1,567 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3157

GET https://conductscience.org/api/genes/v1/3157/patents?page=2