Gene · 3158
HMGCS2: 3-hydroxy-3-methylglutaryl-CoA synthase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HMGCS2: 3-hydroxy-3-methylglutaryl-CoA synthase 2. Genes, record 3158. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3158
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P54868 | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 508 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents45
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 35705 | P54868 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8618 | P54868 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8618 | P54868 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 218 | P54868 | Espacenet |
| US 11896678 B2 | 2024-02-13 | 30 | P54868 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 218 | P54868 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 103189 | P54868 | Espacenet |
| US 11124806 B2 | 2021-09-21 | 9 | P54868 | Espacenet |
| US 10429391 B2 | 2019-10-01 | 13 | P54868 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 216140 | P54868 | Espacenet |
1 to 10 of 45
See all 45 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants960
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HMGCS2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 7 | 2025 |
| P30DK026743 | UCSF Liver Center | 5 | 2025 |
| P30ES007033 | University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment | 5 | 2025 |
| ZIABC005562 | Xenobiotic receptors | 5 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 3 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 3 | 2025 |
| T32AG000212 | Research Training in Geriatric Medicine | 3 | 2025 |
1 to 10 of 960Source NIH's project files
See all 960 nih grantsPapers1,554
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Highly expressed ACSF2 contributes to butyrate utilization in the rumen epithelium. | J Nutr Biochem | 2027 | 42543122 | PubTator, text mining | PubMed |
| Statement of Retraction: HMGCS2 silencing attenuates high glucose-induced in vitro diabetic cardiomyopathy by increasing cell viability, and inhibiting apoptosis, inflammation, and oxidative stress. | Bioengineered | 2026 | 42821437 | PubTator, text mining | PubMed |
| A ketogenic enzyme HMGCS2 drives malignant progression in HER2-negative breast cancer via RAB23-mediated β-catenin/TCF signaling and mediates Apatinib resistance. | Life Sci | 2026 | 42777857 | PubTator, text mining | PubMed |
| Ketone metabolism defects in childhood: a spectrum of overlapping presentations and clinical features. | J Pediatr Endocrinol Metab | 2026 | 42741830 | PubTator, text mining | PubMed |
| Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma. | Nat Commun | 2026 | 42711296 | PubTator, text mining | PubMed |
| Multi-Omics Integration Identifies a Five-Gene Metabolic Signature With Experimental Validation in Clear Cell Renal Cell Carcinoma. | Cancer Rep (Hoboken) | 2026 | 42702836 | PubTator, text mining | PubMed |
| Microglia-Mediated Ependymal Injury in Bacille Calmette-Guérin-Induced Meningitis Is Attenuated by Sodium Butyrate with Restoration of Hmgcs2 Expression. | Adv Respir Med | 2026 | 42644875 | PubTator, text mining | PubMed |
| SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2. | J Clin Invest | 2026 | 42383358 | PubTator, text mining | PubMed |
| Beyond proteostasis: LONP1 as an immunometabolic checkpoint in health and disease. | Biochem Pharmacol | 2026 | 42302976 | PubTator, text mining | PubMed |
Diagnostic value and immune microenvironment regulatory network of metabolic reprogramming in chronic rhinosinusitis with nasal polyps identified by multidimensional transcriptome integration and machine learning. | Front Immunol | 2026 | 42266688 | PubTator, text mining | PubMed |
1 to 10 of 1,554
See all 1,554 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3158
GET https://conductscience.org/api/genes/v1/3158/patents?page=2