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Gene · 3158

HMGCS2: 3-hydroxy-3-methylglutaryl-CoA synthase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HMGCS2: 3-hydroxy-3-methylglutaryl-CoA synthase 2. Genes, record 3158. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3158

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Gene

Symbol
HMGCS2
HGNC
Name
3-hydroxy-3-methylglutaryl-CoA synthase 2
HGNC
NCBI Gene ID
3158
NCBI Gene
HGNC ID
HGNC:5008
HGNC
Ensembl
ENSG00000134240
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P54868Hydroxymethylglutaryl-CoA synthase, mitochondrial5081Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435705P54868Espacenet
EP 4650780 A22025-11-198618P54868Espacenet
JP 2025517970 A2025-06-128618P54868Espacenet
JP 2025062604 A2025-04-14218P54868Espacenet
US 11896678 B22024-02-1330P54868Espacenet
US 11446398 B22022-09-20218P54868Espacenet
JP 2022524081 A2022-04-27103189P54868Espacenet
US 11124806 B22021-09-219P54868Espacenet
US 10429391 B22019-10-0113P54868Espacenet
JP 2019054813 A2019-04-11216140P54868Espacenet

1 to 10 of 45

See all 45 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants960

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHMGCS2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant72025
P30DK026743UCSF Liver Center52025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment52025
ZIABC005562Xenobiotic receptors52025
P30AI027763UCSF-Bay Area Center for AIDS Research32025
P30CA016672Cancer Center Support Grant32025
P30CA046934University of Colorado Cancer Center Support Grant32025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital32025
T32AG000212Research Training in Geriatric Medicine32025

1 to 10 of 960Source NIH's project files

See all 960 nih grants

Papers1,554

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Highly expressed ACSF2 contributes to butyrate utilization in the rumen epithelium.J Nutr Biochem202742543122PubTator, text miningPubMed
Statement of Retraction: HMGCS2 silencing attenuates high glucose-induced in vitro diabetic cardiomyopathy by increasing cell viability, and inhibiting apoptosis, inflammation, and oxidative stress.Bioengineered202642821437PubTator, text miningPubMed
A ketogenic enzyme HMGCS2 drives malignant progression in HER2-negative breast cancer via RAB23-mediated β-catenin/TCF signaling and mediates Apatinib resistance.Life Sci202642777857PubTator, text miningPubMed
Ketone metabolism defects in childhood: a spectrum of overlapping presentations and clinical features.J Pediatr Endocrinol Metab202642741830PubTator, text miningPubMed
Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma.Nat Commun202642711296PubTator, text miningPubMed
Multi-Omics Integration Identifies a Five-Gene Metabolic Signature With Experimental Validation in Clear Cell Renal Cell Carcinoma.Cancer Rep (Hoboken)202642702836PubTator, text miningPubMed
Microglia-Mediated Ependymal Injury in Bacille Calmette-Guérin-Induced Meningitis Is Attenuated by Sodium Butyrate with Restoration of Hmgcs2 Expression.Adv Respir Med202642644875PubTator, text miningPubMed
SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2.J Clin Invest202642383358PubTator, text miningPubMed
Beyond proteostasis: LONP1 as an immunometabolic checkpoint in health and disease.Biochem Pharmacol202642302976PubTator, text miningPubMed
Diagnostic value and immune microenvironment regulatory network of metabolic reprogramming in chronic rhinosinusitis with nasal polyps identified by multidimensional transcriptome integration and machine learning.
Front Immunol202642266688PubTator, text miningPubMed

1 to 10 of 1,554

See all 1,554 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3158

GET https://conductscience.org/api/genes/v1/3158/patents?page=2