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Gene · 316

AOX1: aldehyde oxidase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AOX1: aldehyde oxidase 1. Genes, record 316. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/316

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Gene

Symbol
AOX1
HGNC
Name
aldehyde oxidase 1
HGNC
NCBI Gene ID
316
NCBI Gene
HGNC ID
HGNC:553
HGNC
Ensembl
ENSG00000138356
NCBI Gene
Aliases
AO, AOH1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q06278Aldehyde oxidase1,3387Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437053Q06278Espacenet
EP 4650780 A22025-11-199508Q06278Espacenet
EP 4641201 A22025-10-299755Q06278Espacenet
JP 2025517969 A2025-06-129755Q06278Espacenet
JP 2025517970 A2025-06-129508Q06278Espacenet
JP 2025062604 A2025-04-143949Q06278Espacenet
JP 2025032204 A2025-03-1124500Q06278Espacenet
EP 4461818 A22024-11-1324500Q06278Espacenet
JP 2023058610 A2023-04-2524500Q06278Espacenet
US 11446398 B22022-09-203949Q06278Espacenet

1 to 10 of 42

See all 42 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants967

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAOX1 papersNewest fiscal year
ZIADK025104Clinical Applications of Nitrite and Nitrate82025
P30CA016672Cancer Center Support Grant62025
P30CA021765Cancer Center Support Grant (CCSG)52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
R01HD081299Ontogeny of drug transport52025
R01HL098032Omics, mice and men: Development of precision transfusion medicine52025
P30CA014051Cancer Center Support (Core) Grant42025
R01MH062646Regulation of Signaling by mGluR542025
R35GM143044Interindividual Variability in Drug Metabolism in Ethnically Diverse Populations42025
ZIATR000369Pharmacokinetics and Drug Metabolism42025

1 to 10 of 967Source NIH's project files

See all 967 nih grants

Papers2,549

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Evaluating the Impact of CYP1A2 Inhibition on the Pharmacokinetics of Savolitinib: A Phase 1 Open-Label Study.Pharmacol Res Perspect202642773719PubTator, text miningPubMed
Clinical Pharmacokinetics and Disposition of Imrecoxib.Clin Pharmacokinet202642754736PubTator, text miningPubMed
Aryl hydrocarbon receptor as a molecular mediator in the induction of human aldehyde oxidase gene expression.J Pharmacol Exp Ther202642664535PubTator, text miningPubMed
Structure of human aldehyde oxidase under tris(2-carboxyethyl)phosphine reducing conditions.Acta Crystallogr F Struct Biol Commun202642504845PubTator, text miningPubMed
Integrated Multi-Omics Analysis of 2,3,7,8-TCDD-induced Renal Cell Carcinoma Reveals Core Targets and Mechanistic Pathways.Curr Med Chem202642474018PubTator, text miningPubMed
Post-mortem degradation of flunitrazepam by aldehyde oxidase 1 and hemoglobin in blood.Forensic Toxicol202642323760PubTator, text miningPubMed
NOX4 suppresses malignant progression in prostate adenocarcinoma and functions as a potential diagnostic biomarker.Transl Androl Urol202642293855PubTator, text miningPubMed
Homeostasis of Molybdenum, Xanthine Oxidase and Aldehyde Oxidase Activity Levels in the Livers of Patients with End-Stage Liver Failure and Healthy Controls.Int J Mol Sci202642278524PubTator, text miningPubMed
Comparative transcriptomic analysis of endometrial tissue associated with uterine fibroids and endometrial polyps.Sci Rep202642259941PubTator, text miningPubMed
Role of pregnane X receptor in the upregulation of human aldehyde oxidase gene expression.Biochem Pharmacol202642178049PubTator, text miningPubMed

1 to 10 of 2,549

See all 2,549 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/316

GET https://conductscience.org/api/genes/v1/316/patents?page=2