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Gene · 3163

HMOX2: heme oxygenase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HMOX2: heme oxygenase 2. Genes, record 3163. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3163

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Gene

Symbol
HMOX2
HGNC
Name
heme oxygenase 2
HGNC
NCBI Gene ID
3163
NCBI Gene
HGNC ID
HGNC:5014
HGNC
Ensembl
ENSG00000103415
NCBI Gene
Aliases
HO-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30519Heme oxygenase 23167Ensembl, GeneID, HGNC

Source UniProt

Patents87

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448872P30519Espacenet
JP 2026004568 A2026-01-1448873P30519Espacenet
JP 2026004568 A2026-01-1448874P30519Espacenet
JP 2026004568 A2026-01-1448875P30519Espacenet
JP 2026004568 A2026-01-1448876P30519Espacenet
JP 2026004568 A2026-01-1448877P30519Espacenet
EP 4650780 A22025-11-19459P30519Espacenet
JP 2025529142 A2025-09-041977P30519Espacenet
US 12371689 B22025-07-291977P30519Espacenet
JP 2025517970 A2025-06-12459P30519Espacenet

1 to 10 of 87

See all 87 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,242

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHMOX2 papersNewest fiscal year
P30ES001247Environmental Agents as Modulators of Disease Processes152025
R01DK052766Mechanotransduction in Intestinal Smooth Muscle Cells62025
R01DK057061Calcium Dynamics in Interstitial Cells of Cajal42025
P20GM121334Mississippi Center of Excellence in Perinatal Research, Phase 232025
P30CA016672Cancer Center Support Grant32025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center32025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)32025
R01GM111097Biological Transition Metals32025
R35GM141758Metalloprotein Mechanisms of Redox Regulation and Catalysis32025
P30CA008748Cancer Center Support Grant22025

1 to 10 of 1,242Source NIH's project files

See all 1,242 nih grants

Papers2,258

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genome-wide transcriptomics and a machine learning-based random forest model identify novel biomarkers to predict phenotypic variability in Wilson disease.Hum Immunol202642826579PubTator, text miningPubMed
Collinear UV-mid-IR cross-validation updates HO2 self-reaction kinetics and implications for tropospheric HOx and H2O2.Proc Natl Acad Sci U S A202642771500PubTator, text miningPubMed
Integrated analysis of bulk transcriptomics and single-cell transcriptomics revealed the association characteristics between heart failure and β-hydroxybutyrylation-related genes.PLoS One202642758764PubTator, text miningPubMed
HMOX2-driven crosstalk between vascular aging and heart failure: A multimodal bioinformatics and explainable machine learning approach with experimental validation.PLoS One202642743238PubTator, text miningPubMed
Machine Learning-Based Identification of Survival-Associated CpG Biomarkers in Pancreatic Ductal Adenocarcinoma.J Precis Med (Amst)202642677177PubTator, text miningPubMed
Hydroxyl radical as an indoor oxidant.Environ Sci Atmos202642631256PubTator, text miningPubMed
Decamethylcyclopentasiloxane (D5) Oxidation: Product Chemistry, Influence of RO2 Fate, and Secondary Aerosol Production.ACS EST Air202642621546PubTator, text miningPubMed
[Functions and measurement methods of organelle contact sites].Nihon Yakurigaku Zasshi202642386632PubTator, text miningPubMed
Carbon Monoxide: A Context-Dependent Regulator of the Stress Axis.Biomolecules202642352364PubTator, text miningPubMed
Identification and multi-layered validation of seven diagnostic biomarkers for dilated cardiomyopathy via integrative machine learning, single-cell transcriptomics, and Mendelian randomization.Front Cell Dev Biol202642343898PubTator, text miningPubMed

1 to 10 of 2,258

See all 2,258 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3163

GET https://conductscience.org/api/genes/v1/3163/patents?page=2