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APAF1: apoptotic peptidase activating factor 1

1 protein, 32 patents, 0 drugs, 0 trials, 3,251 NIH grants and 8,636 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAPAF1HGNC
Nameapoptotic peptidase activating factor 1HGNC
NCBI Gene ID317NCBI Gene
HGNC IDHGNC:576HGNC
EnsemblENSG00000120868NCBI Gene
AliasesAPAF-1, CED4NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O14727Apoptotic protease-activating factor 11,24814Ensembl, GeneID, HGNCUniProt

Patents 32

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1916547O14727Espacenet
EP 4641201 A22025-10-2920376O14727Espacenet
JP 2025517969 A2025-06-1220376O14727Espacenet
JP 2025517970 A2025-06-1216547O14727Espacenet
JP 2025062604 A2025-04-145899O14727Espacenet
JP 2024123008 A2024-09-104881O14727Espacenet
US 11708396 B22023-07-251405O14727Espacenet
US 11446398 B22022-09-205899O14727Espacenet
JP 2022524081 A2022-04-27108870O14727Espacenet
WO 2020043864 A12020-03-05173O14727Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3251

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant312,025NIH's project files
P30CA008748Cancer Center Support Grant192,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)132,025NIH's project files
P40OD010440Caenorhabditis Genetics Center102,025NIH's project files
P01CA013106Targeting Transcription and Splicing in Cancer92,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant92,025NIH's project files
R01AI124346Innate immune signaling and stress response82,025NIH's project files
P30CA016058Cancer Center Support Grant62,025NIH's project files
P30CA030199Cancer Center Support Grant (CCSG)62,025NIH's project files
P30CA042014Cancer Center Support Grant62,025NIH's project files

Papers 8636

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42686586PubTator, text miningPubMed
42636949PubTator, text miningPubMed
42589366PubTator, text miningPubMed
42514111PubTator, text miningPubMed
42427257PubTator, text miningPubMed
42368458PubTator, text miningPubMed
42299010PubTator, text miningPubMed
42279358PubTator, text miningPubMed
42205865PubTator, text miningPubMed
42184031PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license