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HNF4A: hepatocyte nuclear factor 4 alpha

1 protein, 74 patents, 1 drug, 2 trials, 10,775 NIH grants and 20,534 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHNF4AHGNC
Namehepatocyte nuclear factor 4 alphaHGNC
NCBI Gene ID3172NCBI Gene
HGNC IDHGNC:5024HGNC
EnsemblENSG00000101076NCBI Gene
AliasesFRTS4, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF-14, TCF14NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P41235Hepatocyte nuclear factor 4-alpha4748Ensembl, GeneID, HGNCUniProt

Patents 74

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4805378 A12026-09-16625P41235Espacenet
EP 4705462 A22026-03-1182P41235Espacenet
JP 2026004568 A2026-01-1448957P41235Espacenet
EP 4640849 A22025-10-29671P41235Espacenet
EP 4641201 A22025-10-294445P41235Espacenet
JP 2025147176 A2025-10-0615107P41235Espacenet
JP 2025121934 A2025-08-201P41235Espacenet
JP 2025525390 A2025-08-053663P41235Espacenet
JP 2025519096 A2025-06-24671P41235Espacenet
JP 2025517969 A2025-06-124445P41235Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALVERINECHEMBL253371Hepatocyte nuclear factor 4-alpha activatorACTIVATORChEMBL

Trials 2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06696248ALVERINEPHASE2/PHASE3ClinicalTrials.gov
NCT05508633ALVERINEPHASE2ClinicalTrials.gov

NIH grants 10775

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant972,025NIH's project files
P30CA008748Cancer Center Support Grant652,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)332,025NIH's project files
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease322,025NIH's project files
P30CA068485Cancer Center Support Grant302,025NIH's project files
P30CA062203Cancer Center Support Grant292,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases282,025NIH's project files
P30CA016058Cancer Center Support Grant272,025NIH's project files
P30DK020595Diabetes Research and Training Center272,025NIH's project files
P40OD010440Caenorhabditis Genetics Center262,025NIH's project files

Papers 20534

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42804630PubTator, text miningPubMed
42787072PubTator, text miningPubMed
42785681PubTator, text miningPubMed
42782345PubTator, text miningPubMed
42780575PubTator, text miningPubMed
42777857PubTator, text miningPubMed
42776184PubTator, text miningPubMed
42769851PubTator, text miningPubMed
42765067PubTator, text miningPubMed
42763390PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license