Gene · 3196
TLX2: T cell leukemia homeobox 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TLX2: T cell leukemia homeobox 2. Genes, record 3196. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3196
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43763 | T-cell leukemia homeobox protein 2 | 284 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents15
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 66621 | O43763 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15788 | O43763 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15788 | O43763 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15788 | O43763 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15627 | O43763 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 87316 | O43763 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 190287 | O43763 | Espacenet |
| JP 2021536249 A | 2021-12-27 | 15981 | O43763 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 11620 | O43763 | Espacenet |
| JP 2021507703 A | 2021-02-25 | 15941 | O43763 | Espacenet |
1 to 10 of 15
See all 15 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants916
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TLX2 papers | Newest fiscal year |
|---|---|---|---|
| R01HL131517 | Sex-specific arrhythmogenic mechanisms of atrial fibrillation | 3 | 2025 |
| P01HL141084 | Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology | 2 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 2 | 2025 |
| R01DE017102 | TRPC1, Calcium, and Saliva Secretion | 2 | 2025 |
| R01HL085844 | Functional interactions of cardiac ion channels | 2 | 2025 |
| R01HL092097 | Calmodulin and Regulation of Cardiac Ryanodine Receptor and CaMKII | 2 | 2025 |
| R01HL128368 | Engineered Stem Cells for Cardiac Repair | 2 | 2025 |
| R01HL139472 | Does biocompatibility contribute to transfusion-related adverse effects? | 2 | 2025 |
| R01HL155762 | IP3 receptor, NOX2 and calcium signaling domains in atrial physiology and pathophysiology | 2 | 2025 |
| R01HL164453 | Atrial Excitation-Contraction Coupling, Calcium Signaling and Electro-Mechanical Alternans | 2 | 2025 |
1 to 10 of 916Source NIH's project files
See all 916 nih grantsPapers1,343
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Distinct Mechanisms of Sodium-Calcium Exchanger NCX1.4 Regulation by Ca2+, ATP, and PIP2. | Cells | 2026 | 42782798 | PubTator, text mining | PubMed |
| Inhibition of sodium-calcium exchanger by tricyclic antidepressants. | Front Pharmacol | 2026 | 42676393 | PubTator, text mining | PubMed |
| Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart. | J Precis Med (Amst) | 2026 | 42644057 | PubTator, text mining | PubMed |
| Calcium and TRPML-Mediated Autophagy: Implications in Cancer, Cardiovascular Diseases, and Cardio-Oncology. | Cardiovasc Toxicol | 2026 | 42414743 | PubTator, text mining | PubMed |
Bradykinin modulates endothelin-1-enhanced and monocrotaline-induced pulmonary arterial hypertension-associated arrhythmogenesis in rabbit right ventricular outflow tract via a nitric oxide-dependent pathway. | Eur J Pharmacol | 2026 | 42035941 | PubTator, text mining | PubMed |
| Harnessing NCX-IP 3 R-dependent Calcium Oscillations to Regulate Angiogenic Signaling in Endothelial Cells. | bioRxiv | 2026 | 41993255 | PubTator, text mining | PubMed |
| Cardiac contractility modulation in heart failure management: unraveling molecular mechanisms to improve patient selection in heart failure management. | Heart Fail Rev | 2026 | 41910667 | PubTator, text mining | PubMed |
| Structural and Functional Regulation of RyR2 in Cardiac Calcium Handling and Arrhythmogenesis. | Biomedicines | 2026 | 41898308 | PubTator, text mining | PubMed |
| The Therapeutic Crossroad Between Mitochondria and Cannabidiol: A Mini-Review. | Biology (Basel) | 2026 | 41892270 | PubTator, text mining | PubMed |
| Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models. | Signal Transduct Target Ther | 2026 | 41872178 | PubTator, text mining | PubMed |
1 to 10 of 1,343
See all 1,343 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3196
GET https://conductscience.org/api/genes/v1/3196/patents