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Gene · 3196

TLX2: T cell leukemia homeobox 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TLX2: T cell leukemia homeobox 2. Genes, record 3196. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3196

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Gene

Symbol
TLX2
HGNC
Name
T cell leukemia homeobox 2
HGNC
NCBI Gene ID
3196
NCBI Gene
HGNC ID
HGNC:5057
HGNC
Ensembl
ENSG00000115297
NCBI Gene
Aliases
Enx, HOX11L1, NCX
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43763T-cell leukemia homeobox protein 22841Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1466621O43763Espacenet
JP 2025147176 A2025-10-0615788O43763Espacenet
JP 2025028160 A2025-02-2815788O43763Espacenet
KR 1020250010750 A2025-01-2115788O43763Espacenet
JP 2024109657 A2024-08-1415627O43763Espacenet
US 11446398 B22022-09-2087316O43763Espacenet
JP 2022524081 A2022-04-27190287O43763Espacenet
JP 2021536249 A2021-12-2715981O43763Espacenet
US 11078247 B22021-08-0311620O43763Espacenet
JP 2021507703 A2021-02-2515941O43763Espacenet

1 to 10 of 15

See all 15 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants916

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTLX2 papersNewest fiscal year
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation32025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology22025
P30CA006927Comprehensive Cancer Center Program at Fox Chase22025
R01DE017102TRPC1, Calcium, and Saliva Secretion22025
R01HL085844Functional interactions of cardiac ion channels22025
R01HL092097Calmodulin and Regulation of Cardiac Ryanodine Receptor and CaMKII22025
R01HL128368Engineered Stem Cells for Cardiac Repair22025
R01HL139472Does biocompatibility contribute to transfusion-related adverse effects?22025
R01HL155762IP3 receptor, NOX2 and calcium signaling domains in atrial physiology and pathophysiology22025
R01HL164453Atrial Excitation-Contraction Coupling, Calcium Signaling and Electro-Mechanical Alternans22025

1 to 10 of 916Source NIH's project files

See all 916 nih grants

Papers1,343

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Distinct Mechanisms of Sodium-Calcium Exchanger NCX1.4 Regulation by Ca2+, ATP, and PIP2.Cells202642782798PubTator, text miningPubMed
Inhibition of sodium-calcium exchanger by tricyclic antidepressants.Front Pharmacol202642676393PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
Calcium and TRPML-Mediated Autophagy: Implications in Cancer, Cardiovascular Diseases, and Cardio-Oncology.Cardiovasc Toxicol202642414743PubTator, text miningPubMed
Bradykinin modulates endothelin-1-enhanced and monocrotaline-induced pulmonary arterial hypertension-associated arrhythmogenesis in rabbit right ventricular outflow tract via a nitric oxide-dependent pathway.
Eur J Pharmacol202642035941PubTator, text miningPubMed
Harnessing NCX-IP 3 R-dependent Calcium Oscillations to Regulate Angiogenic Signaling in Endothelial Cells.bioRxiv202641993255PubTator, text miningPubMed
Cardiac contractility modulation in heart failure management: unraveling molecular mechanisms to improve patient selection in heart failure management.Heart Fail Rev202641910667PubTator, text miningPubMed
Structural and Functional Regulation of RyR2 in Cardiac Calcium Handling and Arrhythmogenesis.Biomedicines202641898308PubTator, text miningPubMed
The Therapeutic Crossroad Between Mitochondria and Cannabidiol: A Mini-Review.Biology (Basel)202641892270PubTator, text miningPubMed
Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models.Signal Transduct Target Ther202641872178PubTator, text miningPubMed

1 to 10 of 1,343

See all 1,343 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3196

GET https://conductscience.org/api/genes/v1/3196/patents