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APC: APC regulator of Wnt signaling pathway

1 protein, 108 patents, 0 drugs, 0 trials, 18,555 NIH grants and 45,771 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAPCHGNC
NameAPC regulator of Wnt signaling pathwayHGNC
NCBI Gene ID324NCBI Gene
HGNC IDHGNC:583HGNC
EnsemblENSG00000134982NCBI Gene
AliasesBTPS2, DESMD, DP2, DP2.5, DP3, GS, PPP1R46NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P25054Adenomatous polyposis coli protein2,84331Ensembl, GeneID, HGNCUniProt

Patents 108

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026000906 A2026-01-06238P25054Espacenet
EP 4650780 A22025-11-191632P25054Espacenet
EP 4640849 A22025-10-29190P25054Espacenet
EP 4641201 A22025-10-291240P25054Espacenet
JP 2025519096 A2025-06-24190P25054Espacenet
JP 2025517969 A2025-06-121240P25054Espacenet
JP 2025517970 A2025-06-121632P25054Espacenet
JP 2025062604 A2025-04-142660P25054Espacenet
JP 2025062604 A2025-04-142665P25054Espacenet
EP 4522752 A12025-03-1916P25054Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 18555

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant3232,025NIH's project files
P30CA008748Cancer Center Support Grant3142,025NIH's project files
P30CA006973Regional Oncology Research Center1002,025NIH's project files
P30CA016058Cancer Center Support Grant792,025NIH's project files
P30CA015704Cancer Center Support Grant642,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028632,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase562,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases562,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)542,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award542,025NIH's project files

Papers 45771

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823566PubTator, text miningPubMed
42814099PubTator, text miningPubMed
42811579PubTator, text miningPubMed
42810540PubTator, text miningPubMed
42809631PubTator, text miningPubMed
42808355PubTator, text miningPubMed
42807355PubTator, text miningPubMed
42806659PubTator, text miningPubMed
42799816PubTator, text miningPubMed
42795000PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license