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Gene · 3248

HPGD: 15-hydroxyprostaglandin dehydrogenase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HPGD: 15-hydroxyprostaglandin dehydrogenase. Genes, record 3248. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3248

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Gene

Symbol
HPGD
HGNC
Name
15-hydroxyprostaglandin dehydrogenase
HGNC
NCBI Gene ID
3248
NCBI Gene
HGNC ID
HGNC:5154
HGNC
Ensembl
ENSG00000164120
NCBI Gene
Aliases
15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P1542815-hydroxyprostaglandin dehydrogenase [NAD(+)]2666Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026139720 A22026-07-0282P15428Espacenet
WO 2025133700 A22025-06-2682P15428Espacenet
JP 2024123008 A2024-09-106520P15428Espacenet
JP 2024532622 A2024-09-05875P15428Espacenet
EP 4395799 A12024-07-10875P15428Espacenet
US 12006548 B22024-06-11400P15428Espacenet
JP 2023528300 A2023-07-04118P15428Espacenet
KR 1020230019450 A2023-02-08117P15428Espacenet
US 11446398 B22022-09-2039251P15428Espacenet
JP 2022524081 A2022-04-27142222P15428Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants853

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHPGD papersNewest fiscal year
P30CA043703Case Comprehensive Cancer Center Support Grant92025
P30ES013508Center of Excellence in Environmental Toxicology72025
P30CA016672Cancer Center Support Grant62025
P30CA068485Cancer Center Support Grant52025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202842025
P30DK058404Molecular and Cellular Basis for Digestive Diseases42025
P30CA008748Cancer Center Support Grant32025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA047904Cancer Center Support Grant32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025

1 to 10 of 853Source NIH's project files

See all 853 nih grants

Papers1,301

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Network pharmacology, single-cell transcriptomics, machine learning and experimental validation identifying CHEK2 and HPGD as key therapeutic targets of berberine in diabetic nephropathy.Funct Integr Genomics202642821141PubTator, text miningPubMed
Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.Nat Rev Drug Discov202642706321PubTator, text miningPubMed
The force-producing fraction: Muscle quality as a therapeutic target in sarcopenia and a design framework for trials that can test it.Ageing Res Rev202642680072PubTator, text miningPubMed
Immune cells harbor their own microbiome-derived metabolome: a new layer of immunometabolic regulation.Front Immunol202642582102PubTator, text miningPubMed
Phosgene inhalation injury in mice: Modeling human pathophysiology, biomarker discovery, and therapeutic target identification.Toxicol Appl Pharmacol202642575345PubTator, text miningPubMed
Urinary Proteomics Enables Noninvasive and Longitudinal Monitoring of Tumor Burden Dynamics and Early Recurrence in Hepatocellular Carcinoma.Mol Cell Proteomics202642575281PubTator, text miningPubMed
Integrated computational analysis identifies FABP4, PTGS2, and HPGD as Key molecular targets linking PET microplastic exposure to metabolic dysfunction-associated steatotic liver disease.PLoS One202642497141PubTator, text miningPubMed
Primary hypertrophic osteoarthropathy complicated with myelofibrosis and compound heterozygous SLCO2A1 mutations: a case report and review of literature.Front Oncol202642453880PubTator, text miningPubMed
BLIMP-1 and CD39 expression define human effector memory regulatory T cells in blood and recall responses to viruses.Immunol Cell Biol202642448314PubTator, text miningPubMed
Decoding the Haematological Enigma: Insights from Primary Hypertrophic Osteoarthropathy Case Studies.Indian J Hematol Blood Transfus202642333191PubTator, text miningPubMed

1 to 10 of 1,301

See all 1,301 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3248

GET https://conductscience.org/api/genes/v1/3248/patents?page=2