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Gene · 3269

HRH1: histamine receptor H1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HRH1: histamine receptor H1. Genes, record 3269. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3269

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Gene

Symbol
HRH1
HGNC
Name
histamine receptor H1
HGNC
NCBI Gene ID
3269
NCBI Gene
HGNC ID
HGNC:5182
HGNC
Ensembl
ENSG00000196639
NCBI Gene
Aliases
H1-R, H1R, HH1R, hisH1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35367Histamine H1 receptor4879Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449114P35367Espacenet
JP 2026004568 A2026-01-1449116P35367Espacenet
JP 2026004568 A2026-01-1449117P35367Espacenet
EP 4650780 A22025-11-1911444P35367Espacenet
EP 4641201 A22025-10-2911984P35367Espacenet
JP 2025529142 A2025-09-041982P35367Espacenet
US 12371689 B22025-07-291982P35367Espacenet
JP 2025517969 A2025-06-1211984P35367Espacenet
JP 2025517970 A2025-06-1211444P35367Espacenet
EP 4440555 A12024-10-0929P35367Espacenet

1 to 10 of 57

See all 57 patents

Drugs113

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACRIVASTINECHEMBL1224Histamine H1 receptor antagonistANTAGONISTChEMBL
ALCAFTADINECHEMBL1201747Histamine H1 receptor antagonistANTAGONISTChEMBL
ANTAZOLINECHEMBL1305Histamine H1 receptor antagonistANTAGONISTChEMBL
ANTAZOLINE PHOSPHATECHEMBL1200550Histamine H1 receptor antagonistANTAGONISTChEMBL
ASTEMIZOLECHEMBL296419Histamine H1 receptor antagonistANTAGONISTChEMBL
AZATADINECHEMBL946Histamine H1 receptor antagonistANTAGONISTChEMBL
AZATADINE MALEATECHEMBL3544908Histamine H1 receptor antagonistANTAGONISTChEMBL
AZELASTINECHEMBL639Histamine H1 receptor antagonistANTAGONISTChEMBL
AZELASTINE HYDROCHLORIDECHEMBL1200809Histamine H1 receptor antagonistANTAGONISTChEMBL
BEPOTASTINECHEMBL1201758Histamine H1 receptor antagonistANTAGONISTChEMBL

1 to 10 of 113

See all 113 drugs

Trials490

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07597473AZELASTINE HYDROCHLORIDEPHASE4ClinicalTrials.gov
NCT07575464LORATADINEClinicalTrials.gov
NCT07566351DESLORATADINEPHASE2ClinicalTrials.gov
NCT07532993LORATADINEPHASE4ClinicalTrials.gov
NCT07486583DESLORATADINEPHASE3ClinicalTrials.gov
NCT07415278AZELASTINE HYDROCHLORIDEPHASE4ClinicalTrials.gov
NCT07381803FEXOFENADINE HYDROCHLORIDEPHASE3ClinicalTrials.gov
NCT07358689DIPHENHYDRAMINEPHASE2ClinicalTrials.gov
NCT07334002BETAHISTINEClinicalTrials.gov
NCT07333716DESLORATADINEPHASE2ClinicalTrials.gov

1 to 10 of 490

See all 490 trials

NIH grants1,218

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHRH1 papersNewest fiscal year
P30DK056338Texas Medical Center Digestive Diseases Center72025
P30CA016672Cancer Center Support Grant32025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease32025
ZIADE000721Molecular Genetic Studies of Somatosensation32025
IK6BX004601BLR&D Research Career Scientist Award22025
P30CA016086Cancer Center Support Grant22025
P30CA046934University of Colorado Cancer Center Support Grant22025
P30DK123704MUSC Digestive Disease Research Core Center22025
P30ES010126UNC Center for Environmental Health and Susceptibility22025
P50CA058223SPORE in Breast Cancer22025

1 to 10 of 1,218Source NIH's project files

See all 1,218 nih grants

Papers3,179

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Antidiabetic Properties of Histamine H1 Receptor Antagonists: A Systematic Review.Antioxidants (Basel)202642792137PubTator, text miningPubMed
Mirtazapine and Slow-Wave Sleep: A Focused Narrative Review of Human Polysomnographic Evidence.Cureus202642761854PubTator, text miningPubMed
Histamine H1 receptor as a potential prophylactic target for COVID-19-induced acute kidney injury during pregnancy.Kidney Res Clin Pract202642745945PubTator, text miningPubMed
GPCR-Driven Muscarinic M1 and Histamine H1 Receptor Signaling Converging on the PI3K/Akt/mTOR Pathway: Functional Integration in Neuroinflammation and Myelin Repair in Multiple Sclerosis.Mol Neurobiol202642714765PubTator, text miningPubMed
Establishment of H1R-SNAP-tag/CMC and screening for anti-allergic active ingredients targeting H1R.Anal Bioanal Chem202642711560PubTator, text miningPubMed
Tape Strip Transcriptomics Reveal Nemolizumab Effects on Pruritus, Hyperplasia, Inflammation, and Extracellular Matrix Markers in Patients With Moderate-to-Severe Atopic Dermatitis.Allergy202642693785PubTator, text miningPubMed
Mast cell-derived histamine negatively regulates hematopoiesis.Exp Hematol202642692326PubTator, text miningPubMed
Virtual Screening, Synthesis and In Vitro Characterization of Histamine H4 Receptor Ligands Based on Pyrimidine Scaffolds.Int J Mol Sci202642589546PubTator, text miningPubMed
Receptor Contribution Reallocation After Removal of Literature-Derived Weights: A Secondary Sensitivity Analysis of the Integrated Ki-DDD-TWAS Pipeline for Antipsychotic Lipid-Trait Prioritization.Cureus202642540671PubTator, text miningPubMed
Preventive Effects of Non-sedating and Sedating Histamine H1 Receptor Antagonists Premedication for Subcutaneous Daratumumab-Associated Infusion-Related Reactions: A Prospective Observational Study.Biol Pharm Bull202642528221PubTator, text miningPubMed

1 to 10 of 3,179

See all 3,179 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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