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Gene · 327

APEH: acylaminoacyl-peptide hydrolase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. APEH: acylaminoacyl-peptide hydrolase. Genes, record 327. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/327

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Gene

Symbol
APEH
HGNC
Name
acylaminoacyl-peptide hydrolase
HGNC
NCBI Gene ID
327
NCBI Gene
HGNC ID
HGNC:586
HGNC
Ensembl
ENSG00000164062
NCBI Gene
Aliases
AARE, ACPH, APH, D3F15S2, D3S48E, DNF15S2, OPH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P13798Acylamino-acid-releasing enzyme7320Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454887P13798Espacenet
EP 4650780 A22025-11-193724P13798Espacenet
JP 2025517970 A2025-06-123724P13798Espacenet
JP 2025062604 A2025-04-141798P13798Espacenet
US 11446398 B22022-09-201798P13798Espacenet
JP 2022524081 A2022-04-27104769P13798Espacenet
US 11078247 B22021-08-03628P13798Espacenet
JP 2019054813 A2019-04-11235322P13798Espacenet
JP 2017121241 A2017-07-13235322P13798Espacenet
JP 2015516143 A2015-06-08235322P13798Espacenet

1 to 10 of 15

See all 15 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants716

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAPEH papersNewest fiscal year
P30CA008748Cancer Center Support Grant52025
P30CA036727Buffett Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant42025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment42025
P30DK063491Diabetes Research Center (DRC)32025
R01GM095970Protein-protein interactions in natural product biosynthesis32025
P30CA013148Comprehensive Cancer Center Support Grant22025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital22025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease22025
R01AI171514Structure-based microbially targeted prodrugs22025

1 to 10 of 716Source NIH's project files

See all 716 nih grants

Papers1,530

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
AI-Decoded Multicatalytic Activities Nanozyme Platform: Integrated Identification and Quantification of Multiplexed Pesticide Residues.J Agric Food Chem202642616408PubTator, text miningPubMed
Recombinant Nus-organophosphorus hydrolase (OPH) immobilized carbon quantum dot (CQD) loaded thin films for efficient detection of OP compounds in environmental samples.Analyst202642615109PubTator, text miningPubMed
Synergistically Functioning Cobalt and Zinc Active Centers from the Pyrolysis of Their Bimetallic ZIFs Exhibiting Orders-of-Magnitude Higher Organophosphorus Hydrolase-Mimicking Activity than Either One Alone.
ACS Omega202642598353PubTator, text miningPubMed
A Brain-Targeted Organophosphorus Hydrolase Fusion Protein Mediated by Angiopep-2 Neutralizes Central Organophosphates and Alleviates Neurotoxicity.Int J Nanomedicine202642368404PubTator, text miningPubMed
Protein Abundance of Hydrolytic Drug Metabolizing Enzymes in Different Tissues and across Species.J Med Chem202642342236PubTator, text miningPubMed
Microbial degradation of organophosphorus pesticides: mechanisms, environmental impacts, and future perspectives.World J Microbiol Biotechnol202642240700PubTator, text miningPubMed
Transfer RNA-derived small RNA-Gly activates the ACPH/GRHL1 axis to facilitate liver cell regeneration in acute-on chronic liver failure.Sci China Life Sci202642207451PubTator, text miningPubMed
Ecological and genomic insights into Bacillus altitudinis as a potential indicator of resistance genes in soil antimicrobial resistance pools.Environ Sci Pollut Res Int202642113401PubTator, text miningPubMed
Bioremediation of organophosphorus compounds using highly stable packed bed microreactor developed with OPH (organophosphorus hydrolase) coated nanofiber.Environ Technol202641946508PubTator, text miningPubMed
PEGylated organophosphorus hydrolase combined with butyrylcholinesterase: dual-enzyme synergistic biocatalysis for acute organophosphate poisoning.Bioorg Chem202641946000PubTator, text miningPubMed

1 to 10 of 1,530

See all 1,530 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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