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Gene · 3276

PRMT1: protein arginine methyltransferase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRMT1: protein arginine methyltransferase 1. Genes, record 3276. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3276

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Gene

Symbol
PRMT1
HGNC
Name
protein arginine methyltransferase 1
HGNC
NCBI Gene ID
3276
NCBI Gene
HGNC ID
HGNC:5187
HGNC
Ensembl
ENSG00000126457
NCBI Gene
Aliases
ANM1, HCP1, HRMT1L2, IR1B4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99873Protein arginine N-methyltransferase 13718Ensembl, GeneID, HGNC

Source UniProt

Patents14

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459610Q99873Espacenet
EP 4650780 A22025-11-1913389Q99873Espacenet
EP 4641202 A22025-10-296635Q99873Espacenet
JP 2025517970 A2025-06-1213389Q99873Espacenet
KR 1020250017231 A2025-02-046635Q99873Espacenet
US 11446398 B22022-09-2067994Q99873Espacenet
JP 2022524081 A2022-04-27170965Q99873Espacenet
US 11078247 B22021-08-038962Q99873Espacenet
JP 2019054813 A2019-04-11240045Q99873Espacenet
JP 2017121241 A2017-07-13240045Q99873Espacenet

1 to 10 of 14

See all 14 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,820

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRMT1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant272025
P30CA016672Cancer Center Support Grant192025
R01AA012863Role of alcohol adapted Kupffer cells in the progression and resolution of ALD102025
R01CA166835Targeted therapy for t(8;21)+ AML92025
P30CA023168Cancer Center Support Grant82025
P20GM130457COBRE in Digestive and Liver Disease62025
P30CA021765Cancer Center Support Grant (CCSG)62025
R01GM117275Protein N-terminal Methylation Mechanisms and Inhibition62025
R35GM146749Regulatory Mechanisms of Arginine Methylation62025
P30CA033572Cancer Center Support Grant52025

1 to 10 of 1,820Source NIH's project files

See all 1,820 nih grants

Papers2,987

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Proteomic Signatures of Noise-Induced Hearing Loss in the Mouse Cochlea.Cell Biol Int202642820356PubTator, text miningPubMed
PRMT1 and YBX1 cooperatively transcriptionally activate GPX4 to inhibit ferroptosis and promote breast cancer progression.Cancer Lett202642772505PubTator, text miningPubMed
PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development.Elife202642770556PubTator, text miningPubMed
Protein arginine methyltransferases in cardiovascular disease: mechanisms, therapeutic potential, and future directions.Front Physiol202642746277PubTator, text miningPubMed
PRMT1-Mediated Arginine Methylation Redirects SMAD4 Signaling to Promote Metastasis in Pancreatic Cancer.Cancer Res202642743245PubTator, text miningPubMed
Small-Molecule Activators of PRMT1: Discovery, SAR Analyses, and Proapoptotic Effects in Pancreatic Cancer Cells.J Med Chem202642720487PubTator, text miningPubMed
Retraction: Prmt1-mediated histone H4R3me2a methylation regulates the proliferation, migration and invasion of laryngeal cancer cells by affecting the expression level of NCOA5.Front Oncol202642677160PubTator, text miningPubMed
Gastrodin activates the AMPK signaling pathway by inhibiting PRMT1 to alleviate cerebral ischemia-reperfusion injury.Brain Res202642660379PubTator, text miningPubMed
Negative allosteric regulation of protein arginine methyltransferase 1 (PRMT1) through half-of-sites reactivity.J Biol Chem202642586427PubTator, text miningPubMed
Targeting PRMTs with small-molecule inhibitors: a comprehensive review.RSC Med Chem202642549137PubTator, text miningPubMed

1 to 10 of 2,987

See all 2,987 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3276

GET https://conductscience.org/api/genes/v1/3276/patents