Gene · 3276
PRMT1: protein arginine methyltransferase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PRMT1: protein arginine methyltransferase 1. Genes, record 3276. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3276
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99873 | Protein arginine N-methyltransferase 1 | 371 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents14
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 59610 | Q99873 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 13389 | Q99873 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 6635 | Q99873 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 13389 | Q99873 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 6635 | Q99873 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 67994 | Q99873 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 170965 | Q99873 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 8962 | Q99873 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 240045 | Q99873 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 240045 | Q99873 | Espacenet |
1 to 10 of 14
See all 14 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,820
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PRMT1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 27 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 19 | 2025 |
| R01AA012863 | Role of alcohol adapted Kupffer cells in the progression and resolution of ALD | 10 | 2025 |
| R01CA166835 | Targeted therapy for t(8;21)+ AML | 9 | 2025 |
| P30CA023168 | Cancer Center Support Grant | 8 | 2025 |
| P20GM130457 | COBRE in Digestive and Liver Disease | 6 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| R01GM117275 | Protein N-terminal Methylation Mechanisms and Inhibition | 6 | 2025 |
| R35GM146749 | Regulatory Mechanisms of Arginine Methylation | 6 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 1,820Source NIH's project files
See all 1,820 nih grantsPapers2,987
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Proteomic Signatures of Noise-Induced Hearing Loss in the Mouse Cochlea. | Cell Biol Int | 2026 | 42820356 | PubTator, text mining | PubMed |
| PRMT1 and YBX1 cooperatively transcriptionally activate GPX4 to inhibit ferroptosis and promote breast cancer progression. | Cancer Lett | 2026 | 42772505 | PubTator, text mining | PubMed |
| PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development. | Elife | 2026 | 42770556 | PubTator, text mining | PubMed |
| Protein arginine methyltransferases in cardiovascular disease: mechanisms, therapeutic potential, and future directions. | Front Physiol | 2026 | 42746277 | PubTator, text mining | PubMed |
| PRMT1-Mediated Arginine Methylation Redirects SMAD4 Signaling to Promote Metastasis in Pancreatic Cancer. | Cancer Res | 2026 | 42743245 | PubTator, text mining | PubMed |
| Small-Molecule Activators of PRMT1: Discovery, SAR Analyses, and Proapoptotic Effects in Pancreatic Cancer Cells. | J Med Chem | 2026 | 42720487 | PubTator, text mining | PubMed |
| Retraction: Prmt1-mediated histone H4R3me2a methylation regulates the proliferation, migration and invasion of laryngeal cancer cells by affecting the expression level of NCOA5. | Front Oncol | 2026 | 42677160 | PubTator, text mining | PubMed |
| Gastrodin activates the AMPK signaling pathway by inhibiting PRMT1 to alleviate cerebral ischemia-reperfusion injury. | Brain Res | 2026 | 42660379 | PubTator, text mining | PubMed |
| Negative allosteric regulation of protein arginine methyltransferase 1 (PRMT1) through half-of-sites reactivity. | J Biol Chem | 2026 | 42586427 | PubTator, text mining | PubMed |
| Targeting PRMTs with small-molecule inhibitors: a comprehensive review. | RSC Med Chem | 2026 | 42549137 | PubTator, text mining | PubMed |
1 to 10 of 2,987
See all 2,987 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3276
GET https://conductscience.org/api/genes/v1/3276/patents